Patents by Inventor Gerald Edward Adams

Gerald Edward Adams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chiral [[(2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazol-1-ethanol and related compounds
    Patent number: 5659048
    Abstract: Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: August 19, 1997
    Assignees: British Technology Group Limited, Warner-Lambert Company
    Inventors: Vladimir Genukh Beylin, Anthony Denver Sercel, Howard Daniel Hollis Showalter, Gerald Edward Adams, Edward Martin Fielden, Matthew Alexander Naylor, Ian James Stratford
  • Potentiation of bioreductive agents
    Patent number: 5652255
    Abstract: A human or animal subject having a solid tumour is treated by administering to the subject therapeutically effective amounts of a nitric oxide (NO) synthase inhibitor and a compound which is an imidazole or 1,2,4-triazole derivative of formula (A) ##STR1## wherein X is selected from the group consisting of ##STR2## wherein R is hydrogen or a C.sub.1 -C.sub.6 alkyl group; each of R'.sub.1 to R'.sub.5 is independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.6 alkyl, hydroxy(C.sub.1 -C.sub.6 alkyl), phenyl, (C.sub.1 -C.sub.6 alkyl)phenyl and phenyl(C.sub.1 -C.sub.6 alkyl); m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclisation reaction and which is not negatively-charged; or a physiologically acceptable acid addition salt thereof.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: July 29, 1997
    Assignee: British Technology Group Limited
    Inventors: Gerald Edward Adams, Ian James Stratford, Pauline Joy Wood