Patents by Inventor Gerald H. Thomsen

Gerald H. Thomsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tendon-inducing methods
    Patent number: 7365052
    Abstract: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: April 29, 2008
    Assignees: Genetics Institute, LLC., President and Fellows of Harvard College
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
  • Modulators of Smurf and BMP/TGF? signaling pathways
    Patent number: 7354722
    Abstract: This invention provides unique members of the Hect family of ubiquitin ligases that specifically target BMP and TGF?/activin pathway-specific Smads. The novel ligases have been named Smurf1 and Smurf2. They directly interact with Smads1 and 5 and Smad7, respectively, and regulate the ubiquitination, turnover and activity of Smads and other proteins of these pathways. Smurf1 interferes with biological responses to BMP, but not activin signaling. In amphibian embryos Smurf1 inhibits endogenous BMP signals, resulting in altered pattern formation and cell fate specification in the mesoderm and ectoderm. The present invention provides a unique regulatory link between the ubiquitination pathway and the control of cell fate determination by the TGF? superfamily during embryonic development. Thus, Smurf1 is a negative regulator of Smad1 signal transduction, by targeting Smad1, Smurf1 blocks BMP signaling.
    Type: Grant
    Filed: June 12, 2000
    Date of Patent: April 8, 2008
    Assignee: Signal Pharmaceuticals
    Inventors: Gerald H. Thomsen, Jeffrey Wrana
  • Tendon-inducing compositions
    Patent number: 6984623
    Abstract: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: January 10, 2006
    Assignees: Genetics, Institute Institute, LLC., President and Fellows of Harvard College
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
  • Tendon-inducing compositions
    Publication number: 20040146923
    Abstract: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
    Type: Application
    Filed: February 18, 2004
    Publication date: July 29, 2004
    Applicants: Genetics Institute, LLC, President and Fellows of Harvard College
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
  • Tendon-inducing compositions
    Patent number: 6719968
    Abstract: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: April 13, 2004
    Assignee: Genetics Institute, LLC.
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
  • Tendon-inducing compositions
    Publication number: 20020160494
    Abstract: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
    Type: Application
    Filed: August 31, 2001
    Publication date: October 31, 2002
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
  • Tendon-inducing compositions
    Patent number: 6284872
    Abstract: Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: September 4, 2001
    Assignees: Genetics Institute, Inc., President and Fellows of Harvard College
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
  • BMP-12 and BMP-13 proteins and DNA encoding them
    Patent number: 6027919
    Abstract: The present invention relates to a novel family of purified proteins, and compositions containing such proteins, which compositions are useful for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair. The present invention further relates to DNA molecules, vectors and host cells useful for production of such proteins.
    Type: Grant
    Filed: November 2, 1994
    Date of Patent: February 22, 2000
    Assignee: Genetics Institute, Inc.
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
  • Methods of inducting formation of tendon and/or ligament tissue comprising administering BMP-12, BMP-13, and/or MP-52
    Patent number: 5658882
    Abstract: The present invention relates to methods for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair, using a composition comprising BMP-12, BMP-13 or MP-52, or combinations of the above.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: August 19, 1997
    Assignees: Genetics Institute, Inc., President and Fellows of Harvard College
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton