Abstract: A process for forming a 6-fluoro derivative of compounds in the L-Dopa family comprising the steps of protecting the groups attached to the benzene ring in the compound followed by serially reacting the protected compound with (a) iodine and silver trifluoroacetic acid; (b) Bb.sub.3 ; (c) dit-butyldicarbonate; (d) hexamethyltin; (e) a fluoro compound; (f) hydrobromic acid; and (g) raising the pH to .ltoreq.7.

Abstract: A system and process for the production of nitrogen-13 ammonium ions from a target material in the form of a dilute solution of ethanol in natural water by the reaction of protons with oxygen-16 within the target material. The system includes a device for producing a proton beam which travels along a preselected path and strikes the target material in a target chamber. This target chamber is positioned in the path of the proton beam such that subjection of the target material to the beam produces nitrogen-13 atoms in a predetermined form. These nitrogen-13 atoms are converted in the aqueous solution to ammonium, ions and oxides and are conducted from the target holder to a purification device for collecting a purified product containing such ammonium ions. A cooling system serves to dissipate heat generated during the production of the nitrogen-13 atoms by the reaction of protons with the oxygen. Other solutes for the target material are discussed.