Patents by Inventor Gerard J. O'Malley

Gerard J. O'Malley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Spiro[cyclopent[b]indole-piperidines]
    Patent number: 6479501
    Abstract: Novel spiro[cyclopent[b]indole-piperidines], intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and intermediates, or compositions thereof are disclosed.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: November 12, 2002
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Mark G. Palermo, Gerard J. O'Malley
  • Spiro[cyclopent[b]indole-piperidines]
    Publication number: 20020004601
    Abstract: Novel spiro[cyclopent[b]indole-piperidines], intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and intermediates, or compositions thereof are disclosed.
    Type: Application
    Filed: January 24, 2001
    Publication date: January 10, 2002
    Applicant: Hoechst Marion Roussel, Inc.
    Inventors: Mark G. Palermo, Gerard J. O'Malley
  • Spiro[cyclopent[b]indole-piperidines]
    Patent number: 6229014
    Abstract: Novel spiro[cyclopent[b]indole-piperidines], intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and intermediates, or compositions thereof are disclosed.
    Type: Grant
    Filed: July 24, 2000
    Date of Patent: May 8, 2001
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gerard J. O'Malley, Mark G. Palermo
  • Spiro[cyclopent[b]indole-piperidines]
    Patent number: 6156901
    Abstract: Novel spiro[cyclopent[b]indole-piperidines], intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and intermediates, or compositions thereof are disclosed.
    Type: Grant
    Filed: June 15, 1999
    Date of Patent: December 5, 2000
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gerard J. O'Malley, Mark G. Palermo
  • Substituted 3-(aminoalklamino)-1,2-benzisoxazoles and related compounds
    Patent number: 6046203
    Abstract: This application relates to compounds of the formula ##STR1## wherein R.sup.1,X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 4, 2000
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Gerard J. O'Malley, Mark G. Palermo
  • Spiro[cyclopent[b]indole-piperidines]
    Patent number: 5986097
    Abstract: Novel spiro[cyclopent[b]indole-piperidines], intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro[cyclopent[b]indole-piperidines] and intermediates, or compositions thereof are disclosed.
    Type: Grant
    Filed: March 9, 1998
    Date of Patent: November 16, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Mark G. Palermo, Gerard J. O'Malley
  • Substituted 3-(aminoalkylamino)-1, 2-benzisoxazoles and related compounds
    Patent number: 5925766
    Abstract: This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful or the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.
    Type: Grant
    Filed: March 18, 1997
    Date of Patent: July 20, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gerard J. O'Malley, Mark G. Palermo
  • Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
    Patent number: 5756754
    Abstract: This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.
    Type: Grant
    Filed: June 19, 1997
    Date of Patent: May 26, 1998
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gerard J. O'Malley, Mark G. Palermo
  • Spiro?cyclopent?b!indole-piperidines!
    Patent number: 5756743
    Abstract: Novel spiro?cyclopent?b!indole-piperidines!, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the spiro?cyclopent?b!indole-piperidines! and intermediates, or compositions thereof are disclosed.
    Type: Grant
    Filed: February 18, 1997
    Date of Patent: May 26, 1998
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Mark G. Palermo, Gerard J. O'Malley
  • 2-(piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl) benzofuran-7-ol and carbamate derivatives for treating memory dysfunction
    Patent number: 5708007
    Abstract: These are disclosed novel 2-(piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)benzofuran-7-ol and carbamate derivatives of the formula ##STR1## where the substituents are as defined in the specification, which are useful as acetylcholinesterase inhibitors and as such may be useful for the treatment of Alzheimer's disease and other senile dementias.
    Type: Grant
    Filed: August 27, 1996
    Date of Patent: January 13, 1998
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gerard J. O'Malley, Udo Hedtmann
  • Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
    Patent number: 5580982
    Abstract: This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 3, 1996
    Assignee: Hoechst Marion Roussel Inc.
    Inventors: Gerard J. O'Malley, Mark G. Palermo
  • Substituted 1,2,3,4-tetrahydrocyclopent b!indoles, compositions and use
    Patent number: 5514700
    Abstract: There are disclosed various compounds of the formula below, ##STR1## where n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.Compounds of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 7, 1996
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Helen H. Ong, Gerard J. O'Malley, Michael C. Merriman, Mark G. Palermo
  • Substituted 3-(aminoalkylamino)-1,2-benzisoxazoles and related compounds
    Patent number: 5494908
    Abstract: This application relates to compounds of the formula ##STR1## wherein R.sup.1, X, Y and n are as defined in the specification; and pharmaceutically acceptable addition salts thereof and optical and geometric isomers or racemic mixtures thereof; which compounds are useful for the treatment of various memory dysfunctions characterized by a decreased cholinergic function such as Alzheimer's disease. Compounds of this invention also inhibit monoamine oxidase and hence are useful as antidepressants.
    Type: Grant
    Filed: November 12, 1993
    Date of Patent: February 27, 1996
    Assignee: Hoechst-Roussel Pharmaceutical Incorporated
    Inventors: Gerard J. O'Malley, Mark G. Palermo
  • Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds
    Patent number: 5472975
    Abstract: There are disclosed various compounds of the formula below, ##STR1## where n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.Compounds of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.
    Type: Grant
    Filed: January 4, 1994
    Date of Patent: December 5, 1995
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Helen H. Ong, Gerard J. O'Malley, Michael C. Merriman, Mark G. Palermo
  • Select cyclopent[b]indoles
    Patent number: 5298626
    Abstract: There are disclosed various compounds of the formula below, ##STR1## wherein n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.Compounds of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: March 29, 1994
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Helen H. Ong, Gerard J. O'Malley, Michael C. Merriman, Mark G. Palermo
  • Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[b]indoles and related compounds
    Patent number: 5192789
    Abstract: There are disclosed various compounds of the formula below, ##STR1## where n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.Compounds of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.
    Type: Grant
    Filed: January 9, 1992
    Date of Patent: March 9, 1993
    Assignee: Hoechst-Roussel Pharmaceuticals Incorporated
    Inventors: Helen H. Ong, Gerard J. O'Malley, Michael C. Merriman, Mark G. Palermo
  • Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds
    Patent number: 5100891
    Abstract: There are disclosed various compounds of the formula below, ##STR1## where n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.Compound of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.
    Type: Grant
    Filed: January 18, 1991
    Date of Patent: March 31, 1992
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Helen H. Ong, Gerard J. O'Malley, Michael C. Merriman, Mark G. Palermo
  • Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds
    Patent number: 5091541
    Abstract: There are disclosed various compounds of the formula below, ##STR1## where X is O, S, NH, N-loweralkyl, or N-arylloweralkyl;Y is hydrogen, fluorine, chlorine, bromine, nitro, loweralkyl, loweralkoxy, or triloweralkylsilyl;R.sub.1 is loweralkyl, halogen-substituted loweralkyl, aryl, arylloweralkyl, cycloalkyl, heteroaryl or heteroarylloweralkyl;R.sub.2 is hydrogen, loweralkyl or arylloweralkyl;R.sub.3 is loweralkyl or arylloweralkyl;R.sub.4 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl or loweralkoxycarbonyl;R.sub.5 is hydrogen or loweralkyl; andm is 0 or 1, with the proviso that when m is O, R.sub.1 may also be hydrogen.which compounds are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.
    Type: Grant
    Filed: October 24, 1990
    Date of Patent: February 25, 1992
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Gerard J. O'Malley, Richard C. Allen, John I. White
  • Process for preparing hydrazinocarbonyloxylabdanes
    Patent number: 5041565
    Abstract: Novel hydrazinocarbonyloxylabdanes, intermediates and processes for the preparation thereof, and a method for treating cardiac failure utilizing compounds or compositions thereof are disclosed.
    Type: Grant
    Filed: August 30, 1989
    Date of Patent: August 20, 1991
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Raymond W. Kosley, Jr., Gerard J. O'Malley
  • Hexahydropyrrolo(2,3-B)indole carbamates, ureas, amides and related compounds
    Patent number: 4983616
    Abstract: There are disclosed various compounds of the formula below, ##STR1## where X is O, S, NH, H-loweralkyl, or N-arylloweralkyl;Y is hydrogen, fluorine, chlorine, bromine, nitro, loweralkyl, loweralkoxy, or triloweralkylsilyl;R.sub.1 is loweralkyl, halogen-substituted loweralkyl, aryl, arylloweralkyl, cycloalkyl, heteroaryl or heteroarylloweralkyl;R.sub.2 is hydrogen, loweralkyl or arylloweralkyl;R.sub.3 is loweralkyl or arylloweralkyl;R.sub.4 is hydrogen, loweralkyl, loweralkenyl, loweralkynyl, arylloweralkyl, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl or loweralkoxycarbonyl;R.sub.5 is hydrogen or loweralkyl; andm is 0 or 1, with the proviso that when m is O, R.sub.1 may also be hydrogen,which compounds are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.
    Type: Grant
    Filed: February 1, 1990
    Date of Patent: January 8, 1991
    Assignee: Hoechst-Roussel Pharmaceuticals Inc.
    Inventors: Gerard J. O'Malley, Richard C. Allen, John I. White