Patents by Inventor Gerard R. Colca

Gerard R. Colca has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiazolidinedione analogs for the treatment of NAFLD and metabolic diseases
    Patent number: 11931345
    Abstract: Provided herein are thiazolidinedione analogues that are useful for treating non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), diabetes, and other metabolic inflammation-mediated disease and disorders.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: March 19, 2024
    Assignee: Cirius Therapeutics, Inc.
    Inventor: Gerard R. Colca
  • METHODS AND COMPOSITIONS FOR TREATING SUBJECTS WITH METABOLIC DISORDERS AND CORONAVIRUS INFECTIONS
    Publication number: 20230210825
    Abstract: Provided herein are thiazolidinedione analogues that are useful for treating metabolic disorders and/or coronavirus infections. In some embodiments, the metabolic disorder includes insulin resistance, diabetes, or prediabetes. In some embodiments, the coronavirus is COVID-19.
    Type: Application
    Filed: October 14, 2022
    Publication date: July 6, 2023
    Inventor: Gerard R. COLCA
  • THIAZOLIDINEDIONE ANALOGS FOR THE TREATMENT OF NAFLD AND METABOLIC DISEASES
    Publication number: 20230013627
    Abstract: Provided herein are thiazolidinedione analogues that are useful for treating non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), diabetes, and other metabolic inflammation-mediated disease and disorders. Further, provided herein are non-invasive methods and systems for assessing a subject's risk of having NASH. Moreover, provided herein are non-invasive methods and systems for evaluating whether a treatment of NASH is effective.
    Type: Application
    Filed: May 6, 2022
    Publication date: January 19, 2023
    Inventors: Gerard R. COLCA, Howard C. DITTRICH, Brian K. FARMER, Gad COTTER, Beth Anne COTTER-DAVISON
  • THIAZOLIDINEDIONE ANALOGS FOR THE TREATMENT OF NAFLD AND METABOLIC DISEASES
    Publication number: 20220031667
    Abstract: Provided herein are thiazolidinedione analogues that are useful for treating non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), diabetes, and other metabolic inflammation-mediated disease and disorders.
    Type: Application
    Filed: July 9, 2021
    Publication date: February 3, 2022
    Inventors: Gerard R. COLCA, Howard C. DITTRICH, Brian K. FARMER
  • THIAZOLIDINEDIONE ANALOGS FOR THE TREATMENT OF NAFLD AND METABOLIC DISEASES
    Publication number: 20210361629
    Abstract: Provided herein are thiazolidinedione analogues that are useful for treating non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), diabetes, and other metabolic inflammation-mediated disease and disorders.
    Type: Application
    Filed: May 3, 2019
    Publication date: November 25, 2021
    Inventor: Gerard R. COLCA
  • PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER METABOLIC DISEASES
    Publication number: 20160051529
    Abstract: The present invention relates to PPARy-sparing compounds and pharmaceutical compositions formulated with such compounds that are useful for treating, delaying the onset of, or reducing the symptoms of a neurodegenerative disorder including Huntington's disease, epilepsy, AMS, and MS.
    Type: Application
    Filed: December 5, 2013
    Publication date: February 25, 2016
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • Thiazolidinedione analogues
    Patent number: 9155729
    Abstract: The present invention relates to thiazolidinedione analogs that are useful for treating metabolic inflammation mediated diseases such as diabetes.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: October 13, 2015
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases
    Patent number: 9126959
    Abstract: The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: September 8, 2015
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Steven P. Tanis, Scott D. Larsen
  • Thiazolidinedione Analogues
    Publication number: 20150190385
    Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating metabolic inflammation mediated diseases such as diabetes.
    Type: Application
    Filed: December 30, 2014
    Publication date: July 9, 2015
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES
    Publication number: 20150051406
    Abstract: The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).
    Type: Application
    Filed: October 30, 2014
    Publication date: February 19, 2015
    Inventors: Gerard R. Colca, Steven P. Tanis, Scott D. Larsen
  • PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases
    Patent number: 8912335
    Abstract: The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: December 16, 2014
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Steven P. Tanis, Scott D. Larsen
  • Thiazolidinedione analogues
    Patent number: 8629159
    Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating hypertension.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: January 14, 2014
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • THIAZOLIDINEDIONE ANALOGUES
    Publication number: 20130281414
    Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating liver afflictions such as nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH).
    Type: Application
    Filed: April 20, 2011
    Publication date: October 24, 2013
    Applicant: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Robert C. Gadwood, Timothy Parker
  • Thiazolidinedione analogues
    Patent number: 8389556
    Abstract: The present invention relates to methods of using thiazolidinedione analogues of formula I: for treating Alzheimer's disease The terms R1, R2 and R3 are herein defined.
    Type: Grant
    Filed: May 18, 2011
    Date of Patent: March 5, 2013
    Assignee: Metabolic Soultions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien
  • PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20130053350
    Abstract: The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing neurodegenerative disorders.
    Type: Application
    Filed: December 15, 2010
    Publication date: February 28, 2013
    Applicant: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien, Steve P. Tanis, Scott D. Larsen
  • PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES
    Publication number: 20120322728
    Abstract: The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing diabetes mellitis, optionally in combination with a second treatment. Furthermore, the present invention also provides methods of inducing remission of the symptoms of diabetes mellitis in a patient comprising administering a thiazolidinedione analogue and a GLP-1 agonist.
    Type: Application
    Filed: December 15, 2010
    Publication date: December 20, 2012
    Applicant: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien, Steven P. Tanis, Scott D. Larsen
  • PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF OBESITY AND OTHER METABOLIC DISEASES
    Publication number: 20120316138
    Abstract: The present invention relates to thiazolidinedione analogues and pharmaceutical compositions that are useful for treating and/or preventing obesity or diabetes, optionally in combination with a second treatment therapy such a diet restriction or an increase in duration or exertion in physical activity.
    Type: Application
    Filed: December 15, 2010
    Publication date: December 13, 2012
    Applicant: METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC
    Inventors: Gerard R. Colca, Rolf F. Kletzien, Steven P. Tanis, Scott D. Larsen
  • PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES
    Publication number: 20120309975
    Abstract: The present invention relates to novel salts of thiazolidinediones and other pharmaceutical agents that are useful for treating and/or preventing metabolic diseases (e.g., diabetes, or neurodegenerative diseases (e.g., Alzheimer's Disease).
    Type: Application
    Filed: December 15, 2010
    Publication date: December 6, 2012
    Applicant: Metabolic Solutions Development Company LLC
    Inventors: Gerard R. Colca, Steven P. Tanis, Scott D. Larsen
  • Thiazolidinedione analogues for the treatment of metabolic diseases
    Patent number: 8304441
    Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating hypertension, diabetes, and inflammatory diseases.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: November 6, 2012
    Assignee: Metabolic Solutions Development Company, LLC
    Inventors: Gerard R. Colca, Robert C. Gadwood, Tim Parker
  • THIAZOLIDINEDIONE ANALOGUES FOR THE TREATMENT OF METABOLIC DISEASES
    Publication number: 20120129896
    Abstract: The present invention relates to thiazolidinedione analogues that are useful for treating hypertension, diabetes, and inflammatory diseases.
    Type: Application
    Filed: November 16, 2011
    Publication date: May 24, 2012
    Applicant: Metabolic Solutions Development Company
    Inventors: Gerard R. Colca, Robert C. Gadwood, Tim Parker