Abstract: The present invention pertains to novel treatments of neuropathic pain; in particular chemotherapy induced peripheral neuropathic pain (CIPNP). The invention provides antagonists cytochrome P450 epoxygenases (CYP), and more specifically antagonists of CYP2J2, as therapeutics for use in the treatment of neuropathic pain such as CIPNP. CYP2J2 antagonists were identified to alleviate CIPNP in-vivo, and therefore are provided additionally in combination with chemotherapeutics for the treatment of diseases such as cancer or other proliferative disorders. The CYP2J2 antagonists reduce chemotherapeutic induced pain and therefore allow for a higher dosing of the chemotherapeutic during cancer treatment. In addition the invention relates to the use of CYP2J2 agonists, or metabolites of CYP2J2, for sensitizing TRPV1.

Abstract: A turbine generator contains a turbine part and a generator part. The turbine contains a turbine wheel. A sealing arrangement is arranged between the turbine wheel and the generator part, the sealing effect of which varies during operation. The generator part further has a generator shaft, which is supported by an axial bearing configured as a magnetic bearing with two coils axially spaced apart from each other. A bearing ring is arranged between these coils with an axial distance from the coils. To ensure a safe operation, a setpoint value for the axial distance is varied to change the sealing effect of the sealing arrangement. Alternatively or additionally, it is provided that when a current threshold of a coil current is exceeded, a control signal is emitted to control the flow of the medium or the rotational speed.

Abstract: A turbine generator contains a turbine part and a generator part. The turbine contains a turbine wheel. A sealing arrangement is arranged between the turbine wheel and the generator part, the sealing effect of which varies during operation. The generator part further has a generator shaft, which is supported by an axial bearing configured as a magnetic bearing with two coils axially spaced apart from each other. A bearing ring is arranged between these coils with an axial distance from the coils. To ensure a safe operation, a setpoint value for the axial distance is varied to change the sealing effect of the sealing arrangement. Alternatively or additionally, it is provided that when a current threshold of a coil current is exceeded, a control signal is emitted to control the flow of the medium or the rotational speed.

Abstract: A device for direct screwing, in particular flow hole screwing, or friction welding includes a guide element extending in an axial direction and being formed in particular as a guide pipe. A driveshaft is movable in the axial direction, disposed within the guide element and driven by a rotary drive. A feed drive is disposed and constructed to generate a feed movement and feed force transmitted to the driveshaft, which is achieved by a feed unit. During the process, depending on a process parameter, a switchover is made from a high feed force to a reduced feed force (flow hole screwing) or to a higher feed force (friction welding). In order to enable the most compact and weight-saving embodiment possible, the feed unit is disposed coaxially to the driveshaft within the guide element and transmits the feed force to the driveshaft in the axial direction and centrally.

Abstract: A device for direct screwing, in particular flow hole screwing, or friction welding includes a guide element extending in an axial direction and being formed in particular as a guide pipe. A driveshaft is movable in the axial direction, disposed within the guide element and driven by a rotary drive. A feed drive is disposed and constructed to generate a feed movement and feed force transmitted to the driveshaft, which is achieved by a feed unit. During the process, depending on a process parameter, a switchover is made from a high feed force to a reduced feed force (flow hole screwing) or to a higher feed force (friction welding). In order to enable the most compact and weight-saving embodiment possible, the feed unit is disposed coaxially to the driveshaft within the guide element and transmits the feed force to the driveshaft in the axial direction and centrally.

Abstract: In order to achieve high rotational speeds for a drive motor used for surgical purposes without the need for excessive maintenance of this motor, it is proposed that it be in the form of a compressed-fluid-driven, gear-type motor having interengaging gears which are sealed in a housing and have a rotational speed of between 40,000 and 150,000 revolutions per minute.