Abstract: A tamperproof closure for a tube includes a neck projection on a neck of the tube, which neck projection is riveted to an edge of a sleeve section provided in a cap. After the neck projection has been broken off to use the tube, the cap can be replaced on the tube, however, the connection is so loose that when the tube is picked up again, the cap is immediately detached from the neck, thus indicating prior use.

Abstract: An applicator for treating the skin dispenses a predetermined dose of treatment agent. The applicator comprises a cylindrical portion, the front face of which is open, and a closure piece for the open front face. Solid and hollow pins extend axially from a front wall of the cylindrical portion. The hollow pins communicate with the cylinder cavity. The closure piece and the cylindrical portion are designed so that the closure piece delimits a given volume in the cylindrical portion. The closure piece has a central filling opening with a non-return or one-way valve disposed therein.