Patents by Inventor Gerhard Lange
Gerhard Lange has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965030Abstract: Binding proteins comprising a VL region paired with a VH region, and a CH1 region paired with a CL region, wherein the VL region and VH region comprise opposite charged mutations to facilitate pairing, and wherein the CH1 region and CL region comprise mutations to facilitate pairing, are provided. Binding proteins comprising one or more cysteine residues engineered into the VH/VL pair to form one or more disulfide bonds, are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.Type: GrantFiled: December 23, 2019Date of Patent: April 23, 2024Assignee: SANOFIInventors: Marta Amaral, Christian Beil, Ingo Focken, Gerhard Hessler, Soraya Hoelper, Jennifer Jung, Christian Lange, Wulf-Dirk Leuschner, Ercole Rao, Garima Tiwari, Sandra Weil
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Patent number: 9969849Abstract: The present invention relates to a process for drying particulate polymers, comprising the steps of: a) providing a particulate polymer comprising from 60 wt % to 90 wt % of at least one solvent based on the total weight of particulate polymer and solvent, b) mechanically predrying the particulate polymer to a content of the at least one solvent of from 20 wt % to 50 wt % based on the total weight of particulate polymer and solvent, wherein the mechanical predrying in step b) is carried out with a roller press, and c) end-drying the particulate polymer to a content of the at least one solvent of from 0 wt % to 15 wt % based on the total weight of particulate polymer and solvent, wherein the particulate polymer is a polymer comprising repeating units of formulae I, II and/or III The present invention further relates to a process for working up particulate polymers.Type: GrantFiled: February 16, 2015Date of Patent: May 15, 2018Assignee: BASF SEInventors: Joerg Erbes, Gerhard Lange, Tobias Kortekamp, Bernhard Linner, Cecile Schneider, Angela Ulzhoefer, Robert Heinz, Michael Klemens Mueller
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Patent number: 9828472Abstract: Process for producing polyarylene ether beads from a polyarylene ether solution, comprising the steps of i) dividing the polyarylene ether solution into droplets, ii) transferring the droplets into a precipitation bath to form polyarylene ether beads in the precipitation bath which (A) comprises at least one aprotic solvent (component (1)) and at least one protic solvent (component (2)), (B) has a temperature of 0° C. to Tc, where the critical temperature Tc in [° C.] can be determined by the numerical equation Tc=(77?c)/0.58 in which c is the concentration of component (1) in the precipitation bath in [% by weight] and (C) has component (1) in concentrations of 5% by weight to cc, where the critical concentration cc in [% by weight] can be determined by the numerical equation cc=77?0.58*T in which T is the temperature in the precipitation bath in [° C.], where the percentages by weight are each based on the sum of the percentages by weight of component (1) and of component (2) in the precipitation bath.Type: GrantFiled: July 16, 2014Date of Patent: November 28, 2017Assignee: BASF SEInventors: Joerg Erbes, Gerhard Lange, Tobias Kortekamp, Cecile Schneider
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Patent number: 9809685Abstract: Process for producing polyarylene ether beads from a polyarylene ether solution, comprising the steps of i) dividing the polyarylene ether solution into droplets, ii) transferring the droplets into a precipitation bath to form polyarylene ether beads in the precipitation bath which (A) comprises at least one aprotic solvent (component (1)) and at least one protic solvent (component (2)), (B) has a temperature of 0° C. to Tc, where the critical temperature Tc in [° C.] can be determined by the numerical equation Tc=(99?c)/0.61 in which c is the concentration of component (1) in the precipitation bath in [% by weight] and (C) has component (1) in concentrations of 5% by weight to cc, where the critical concentration cc in [% by weight] can be determined by the numerical equation cc=99?0.61*T in which T is the temperature in the precipitation bath in [° C.], where the percentages by weight are each based on the sum of the percentages by weight of component (1) and of component (2) in the precipitation bath.Type: GrantFiled: July 16, 2014Date of Patent: November 7, 2017Assignee: BASF SEInventors: Joerg Erbes, Gerhard Lange, Tobias Kortekamp, Cecile Schneider
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Publication number: 20170081481Abstract: The present invention relates to a process for drying particulate polymers, comprising the steps of: a) providing a particulate polymer comprising from 60 wt % to 90 wt % of at least one solvent based on the total weight of particulate polymer and solvent, b) mechanically predrying the particulate polymer to a content of the at least one solvent of from 20 wt % to 50 wt % based on the total weight of particulate polymer and solvent, wherein the mechanical predrying in step b) is carried out with a roller press, and c) end-drying the particulate polymer to a content of the at least one solvent of from 0 wt % to 15 wt % based on the total weight of particulate polymer and solvent, wherein the particulate polymer is a polymer comprising repeating units of formulae I, II and/or III The present invention further relates to a process for working up particulate polymers.Type: ApplicationFiled: February 16, 2015Publication date: March 23, 2017Applicant: BASF SEInventors: Joerg ERBES, Gerhard LANGE, Tobias KORTEKAMP, Bernhard LINNER, Cecile SCHNEIDER, Angela ULZHOEFER, Robert KEINZ, Michael Klemens MUELLER
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Patent number: 9469732Abstract: The present invention relates to a process for the production of low-halogen-content polybiphenyl sulfone polymers, to the resultant polybiphenyl sulfone polymers, to polybiphenyl sulfone polymers having less than 400 ppm content of polymer-bonded halogen, to thermoplastic molding compositions comprising these polybiphenyl sulfone polymers, and to their use for the production of moldings, of fibers, of films, of membranes, or of foams.Type: GrantFiled: July 31, 2015Date of Patent: October 18, 2016Assignee: BASF SEInventors: Martin Weber, Christian Maletzko, Gerhard Lange, Jörg Erbes, Matthias Dietrich, Nicolas Inchaurrondo, Christoph Sigwart
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Publication number: 20160215105Abstract: Process for producing polyarylene ether beads from a polyarylene ether solution, comprising the steps of i) dividing the polyarylene ether solution into droplets, ii) transferring the droplets into a precipitation bath to form polyarylene ether beads in the precipitation bath which (A) comprises at least one aprotic solvent (component (1)) and at least one protic solvent (component (2)), (B) has a temperature of 0° C. to Tc, where the critical temperature Tc in [° C.] can be determined by the numerical equation Tc=(99?c)/0.61 in which c is the concentration of component (1) in the precipitation bath in [% by weight] and (C) has component (1) in concentrations of 5% by weight to cc, where the critical concentration cc in [% by weight] can be determined by the numerical equation cc=99?0.Type: ApplicationFiled: July 16, 2014Publication date: July 28, 2016Applicant: BASF SEInventors: Joerg ERBES, Gerhard LANGE, Tobias KORTEKAMP, Cecile SCHNEIDER
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Publication number: 20160208056Abstract: Process for producing polyarylene ether beads from a polyarylene ether solution, comprising the steps of i) dividing the polyarylene ether solution into droplets, ii) transferring the droplets into a precipitation bath to form polyarylene ether beads in the precipitation bath which (A) comprises at least one aprotic solvent (component (1)) and at least one protic solvent (component (2)), (B) has a temperature of 0° C. to Tc, where the critical temperature Tc in [° C.] can be determined by the numerical equation Tc=(77?c)/0.58 in which c is the concentration of component (1) in the precipitation bath in [% by weight] and (C) has component (1) in concentrations of 5% by weight to cc, where the critical concentration cc in [% by weight] can be determined by the numerical equation cc=77?0.58*T in which T is the temperature in the precipitation bath in [° C.], where the percentages by weight are each based on the sum of the percentages by weight of component (1) and of component (2) in the precipitation bath.Type: ApplicationFiled: July 16, 2014Publication date: July 21, 2016Applicant: BASF SEInventors: Joerg ERBES, Gerhard LANGE, Tobias KORTEKAMP, Cecile SCHNEIDER
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Patent number: 9365680Abstract: The present invention relates to a process for the production of low-chlorine-content polybiphenyl sulfone polymers, to the polybiphenyl sulfone polymers obtainable in this way, to polybiphenyl sulfone polymers with less than 800 ppm content of organically bonded chlorine, to thermoplastic molding compositions and moldings, fibers, films, membranes, or foams comprising the polybiphenyl sulfone polymers mentioned, and also to their use for the production of moldings, of fibers, of films, of membranes, or of foams.Type: GrantFiled: January 8, 2015Date of Patent: June 14, 2016Assignee: BASF SEInventors: Martin Weber, Christian Maletzko, Gerhard Lange, Jörg Erbes, Matthias Dietrich, Nicholas Inchaurrondo
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Publication number: 20150337085Abstract: The present invention relates to a process for the production of low-halogen-content polybiphenyl sulfone polymers, to the resultant polybiphenyl sulfone polymers, to polybiphenyl sulfone polymers having less than 400 ppm content of polymer-bonded halogen, to thermoplastic molding compositions comprising these polybiphenyl sulfone polymers, and to their use for the production of moldings, of fibers, of films, of membranes, or of foams.Type: ApplicationFiled: July 31, 2015Publication date: November 26, 2015Inventors: Martin WEBER, Christian Maletzko, Gerhard Lange, Jörg Erbes, Matthias Dietrich, Nicolas Inchaurrondo, Christoph Sigwart
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Patent number: 9102798Abstract: The present invention relates to a process for the production of low-halogen-content polybiphenyl sulfone polymers, to the resultant polybiphenyl sulfone polymers, to polybiphenyl sulfone polymers having less than 400 ppm content of polymer-bonded halogen, to thermoplastic molding compositions comprising these polybiphenyl sulfone polymers, and to their use for the production of moldings, of fibers, of films, of membranes, or of foams.Type: GrantFiled: August 17, 2010Date of Patent: August 11, 2015Assignee: BASF SEInventors: Martin Weber, Christian Maletzko, Gerhard Lange, Jörg Erbes, Matthias Dietrich, Nicolas Inchaurrondo, Christoph Sigwart
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Patent number: 9051432Abstract: The present invention relates to a process for the production of low-chlorine-content polybiphenyl sulfone polymers, to the polybiphenyl sulfone polymers obtainable in this way, to polybiphenyl sulfone polymers with less than 800 ppm content of organically bonded chlorine, to thermoplastic molding compositions and moldings, fibers, films, membranes, or foams comprising the polybiphenyl sulfone polymers mentioned, and also to their use for the production of moldings, of fibers, of films, of membranes, or of foams.Type: GrantFiled: March 30, 2010Date of Patent: June 9, 2015Assignee: BASF SEInventors: Martin Weber, Christian Maletzko, Gerhard Lange, Jörg Erbes, Matthias Dietrich, Nicholas Inchaurrondo
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Publication number: 20150119485Abstract: The present invention relates to a process for the production of low-chlorine-content polybiphenyl sulfone polymers, to the polybiphenyl sulfone polymers obtainable in this way, to polybiphenyl sulfone polymers with less than 800 ppm content of organically bonded chlorine, to thermoplastic molding compositions and moldings, fibers, films, membranes, or foams comprising the polybiphenyl sulfone polymers mentioned, and also to their use for the production of moldings, of fibers, of films, of membranes, or of foams.Type: ApplicationFiled: January 8, 2015Publication date: April 30, 2015Inventors: Martin Weber, Christian Maletzko, Gerhard Lange, Jörg Erbes, Matthias Dietrich, Nicholas Inchaurrondo
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Patent number: 8906992Abstract: A thermoplastic molding composition, comprising: A) from 40 to 97.9% by weight of at least one polyether sulfone, B) from 2 to 59.9% by weight of at least one polysulfone, C) from 0.1 to 2% by weight of stearic acid, and also, if appropriate, further additives and auxiliaries, has improved flowability, surface quality, and notched impact resistance, and can be used for the construction of headlamps.Type: GrantFiled: June 19, 2008Date of Patent: December 9, 2014Assignee: BASF SEInventors: Martin Weber, Rüdiger Bluhm, Christian Maletzko, Gerhard Lange, Jörg Erbes
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Publication number: 20140183031Abstract: A process is proposed for the treatment of a recycling stream (1) from a plant for the production of polyarylene ether sulfones via polycondensation of aromatic bishalogen compounds and of aromatic bisphenols or their salts in the presence of at least one alkali metal carbonate or ammonium carbonate or alkali metal hydrogencarbonate or ammonium hydrogencarbonate in an N-alkyl-2-pyrrolidone as solvent, comprising from 60 to 90% by weight of water, from 10 to 40% by weight of the N-alkyl-2-pyrrolidone and, as contaminant detrimental to specification, up to 5000 ppm by weight of the N-alkylsuccinimide corresponding to the N-alkyl-2-pyrrolidone and, alongside this, up to 1000 ppm by weight of other substances with higher boiling point than the N-alkyl-2-pyrrolidone, in particular inorganic salts, based in each case on the total weight of the recycling stream (1), where the entirety of the components gives 100% by weight, giving a pure N-alkyl-2-pyrrolidone stream (2) which can be returned to the plant for the pType: ApplicationFiled: December 26, 2013Publication date: July 3, 2014Applicant: BASF SEInventors: Christoph Sigwart, Cornelies Hendricus De Ruiter, Jörg Erbes, Gerhard Lange, Tobias Kortekamp
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Publication number: 20140183030Abstract: N-alkylpyrrolidone and, as contaminant alongside this, the corresponding N-alkyl-succinimide, to give a pure solvent stream which meets the requirements for use in a process for the production of polymers, where compounds of higher and lower boiling point than the N-alkylpyrrolidone are removed by distillation, which comprises, prior to, during, or after the distillative purification process, adding a hydroxide of an alkali metal or of an alkaline earth metal in a molar amount corresponding to a molar ratio of at least 0.1:1 for this hydroxide with respect to the respective N-alkylsuccinimide in the appropriate solvent stream present prior to, during, or after the distillative purification process.Type: ApplicationFiled: December 26, 2013Publication date: July 3, 2014Applicant: BASE SEInventors: Christoph Sigwart, Jörg Erbes, Martin Weber, Gerhard Lange, Jutta Vonend, Cornelis Hendricus De Ruiter
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Publication number: 20140187737Abstract: A process is proposed for the treatment of a recycling stream (1) from a plant for the production of polyarylene ether sulfones via polycondensation of aromatic bishalogen compounds and of aromatic bisphenols or their salts in the presence of at least one alkali metal carbonate or ammonium carbonate or alkali metal hydrogencarbonate or ammonium hydrogencarbonate in an N-alkyl-2-pyrrolidone as solvent, comprising from 60 to 90% by weight of water, from 10 to 40% by weight of the N-alkyl-2-pyrrolidone and, as contaminant detrimental to specification, up to 5000 ppm by weight of the alkylsuccinimide corresponding to the N-alkyl-2-pyrrolidone and, alongside this, up to 1000 ppm by weight of other substances with higher boiling point than N-alkyl-2-pyrrolidone, in particular inorganic salts, based in each case on the total weight of the recycling stream (1), where the entirety of the components gives 100% by weight, giving a pure N-alkyl-2-pyrrolidone stream (2) which can be returned to the plant for the produType: ApplicationFiled: December 26, 2013Publication date: July 3, 2014Applicant: BASF SEInventors: Jörg Erbes, Cornelis Hendricus De Ruiter, Christoph Sigwart, Gerhard Lange, Jutta Vonend
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Publication number: 20120149796Abstract: The present invention relates to a process for the production of low-halogen-content polybiphenyl sulfone polymers, to the resultant polybiphenyl sulfone polymers, to polybiphenyl sulfone polymers having less than 400 ppm content of polymer-bonded halogen, to thermoplastic molding compositions comprising these polybiphenyl sulfone polymers, and to their use for the production of moldings, of fibers, of films, of membranes, or of foams.Type: ApplicationFiled: August 17, 2010Publication date: June 14, 2012Applicant: BASF SEInventors: Martin Weber, Christian Maletzko, Gerhard Lange, Jörg Erbes, Matthias Dietrich, Nicolas Inchaurrondo, Christoph Sigwart
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Publication number: 20120029106Abstract: The present invention relates to a process for the production of low-chlorine-content polybiphenyl sulfone polymers, to the polybiphenyl sulfone polymers obtainable in this way, to polybiphenyl sulfone polymers with less than 800 ppm content of organically bonded chlorine, to thermoplastic molding compositions and moldings, fibers, films, membranes, or foams comprising the polybiphenyl sulfone polymers mentioned, and also to their use for the production of moldings, of fibers, of films, of membranes, or of foams.Type: ApplicationFiled: March 30, 2010Publication date: February 2, 2012Applicant: BASF SEInventors: Martin Weber, Christian Maletzko, Gerhard Lange, Jörg Erbes, Matthias Dietrich, Nicholas Inchaurrondo
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Publication number: 20110224386Abstract: The present invention relates to a process for the preparation of a polymer composition comprising (a) the provision of at least one polyarylene ether (P) having predominantly terminal phenolate groups in the presence of a solvent (L), (b) the addition of at least one polyfunctional carboxylic acid and (c) the isolation of the polymer composition as a solid. The present invention also relates to polymer compositions obtainable by the process, mixtures which comprise these polyarylene ethers and the use of the polymer compositions according to the invention for toughening epoxy resins.Type: ApplicationFiled: November 12, 2009Publication date: September 15, 2011Inventors: Martin Weber, Christian Maletzko, Gerhard Lange, Jörg Erbes, Matthias Dietrich, Nicholas Inchaurrondo, Tobias Kortekamp, Bernd Trotte