Patents by Inventor Gerhard Sator

Gerhard Sator has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production and use of salts of 6,8-bis (amidiniumthio)-octanoic acid
    Patent number: 6013815
    Abstract: The invention relates to the production and purification of salts of 6,8-bis (amidiniumthio)octanoic acid, its enantiomers (+)-6,8-bis(amidiniumthio)octanoic acid and (-)-6,8-bis (amidiniumthio)octanoic acid and of the esters of these compounds as well as to their use to produce dihydrolipoic acid and .alpha.-lipoic acid.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: January 11, 2000
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Thomas Beisswenger, Rainer Gewald, Alfred Olbrich, Horst Bethge, Frank Hubner, Klaus Huthmacher, Herbert Klenk, Roland Moller, Stephan Rautenberg, Gerhard Sator
  • Method of producing dry thioctic acid
    Patent number: 5981767
    Abstract: The present invention is relative to a method of producing dry thioctic acid in which a raw material in which concentrated thioctic acid is present is treated with liquid or supercritical CO.sub.2, thus yielding thioctic acid with low residual solvent contents in a simple industrial method.
    Type: Grant
    Filed: June 23, 1998
    Date of Patent: November 9, 1999
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Herbert Tanner, Karlheinz Drauz, Gerhard Sator, Horst Bethge, Roland Moller, Frank Hubner, Thomas Tacke, Claus Rehren
  • Process for the preparation of 1-(N 2-(S)-ethoxycarbonyl)--3 phenylpropyl-N6-trifluoracetyl))-L-lysyl-L-prolin (Lisinopril(Tfa) ethylester, LPE))
    Patent number: 5962696
    Abstract: There is provided a process for the work-up of this material having the formula ##STR1## because of its poor crystallizability has heretofore been available only with large yield losses. The yield losses are due to the fact that the crystals of this compound are associated with large amounts of residual solvent material which gives rise to complex and expensive drying procedures. In accordance with the present invention the crude LPE is dried by means of fluid or supercritical carbon dioxide which maces it possible to reduce drying times from the previous range of about 124 hours to about 10 hours for the same amount of product and thus produce a dry LPE which has smaller amounts of residual solvent, as well as smaller by-products than that obtained by conventional drying.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: October 5, 1999
    Assignee: Degussa Aktiengesellschaft
    Inventors: Herbert Tanner, Karlheinz Drauz, Klaus Stingl, Gerhard Sator, Horst Bethge, Roland Moller, Thomas Tacke, Claus Rehren
  • Production and use of salts of 6, 8-bis (amidiniumthio) -octanoic acid
    Patent number: 5760268
    Abstract: The invention relates to the production and purification of salts of 6,8-bis(amidiniumthio) octanoic acid, its enantiomers (+)-6,8-bis(amidiniumthio)octanoic acid and (-)-6,8-bis (amidiniumthio)octanoic acid and of the esters of these compounds as well as to their use to produce dihydrolipoic acid and .alpha.-lipoic acid.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: June 2, 1998
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Thomas Beisswenger, Rainer Gewald, Alfred Olbrich, Horst Bethge, Frank Hubner, Klaus Huthmacher, Herbert Klenk, Roland Moller, Stephan Rautenberg, Gerhard Sator
  • Method of producing flowable R,S-thioctic acid, R,S-thioctic acid and its use
    Patent number: 5705192
    Abstract: 1. A method of producing flowable R,S-thioctic acid, R,S-thioctic acid and its use.2.1. Known methods of preparing flowable thioctic acid which can be galenically further processed by pressing to highly-concentrated, solid presentations with active-substance contents of more than 200 mg pure substance require the mixing of the thioctic-acid forms of different origins and/or a spraying on of galenic adjuvants from aqueous solution and a subsequent grinding process in order to arrive at a pressable granulate.2.2.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: January 6, 1998
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Horst Bethge, Kurt Klostermann, Roland Moller, Gerhard Sator
  • Method for the racemization of enantiomers of .alpha.-lipoic acid
    Patent number: 5621117
    Abstract: Method for the conversion of the enantiomers of .alpha.-lipoic acid into the corresponding racemic mixture by racemizing the .alpha.-lipoic acid (pure optical isomers of .alpha.-lipoic acid or mixtures of optical isomers of .alpha.-lipoic acid wherein one of the optical isomers is present in excess) at temperatures of between 110.degree. C. and 200.degree. C. at pressures of from normal pressure up to 50 bar for a reaction time of 10 to 48 hours.
    Type: Grant
    Filed: July 20, 1995
    Date of Patent: April 15, 1997
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Horst Bethge, Roland Moeller, Gerhard Sator, Stefan Merget, Thomas Beisswenger