Patents by Inventor Gerhard Seemann

Gerhard Seemann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Specific antibodies against activated platelets, the preparation thereof and the use thereof in diagnosis and therapy
    Patent number: 5686583
    Abstract: The invention relates to monoclonal antibodies and parts thereof which bind preferentially to active human platelets, to the nucleotide sequence and amino-acid sequence of the heavy and light chain of MAb BW 2128 and to an antigen associated with thrombospondin.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 11, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Klaus Bosslet, Gerhard Seemann, Beate Kehrel
  • Polynucleotides encoding the anti-PEM antibody BW835 variable domains and expression vectors
    Patent number: 5674994
    Abstract: The invention relates to polynucleotides encoding the BW 835 variable domain of an antibody against a tumor-associated antigen which is mainly derived from tumors from the group of carcinomas of the breast, ovaries and prostate, as well as adenocarcinomas of the lung, which additionally react with polymorphic epithelial mucin (PEM), and expression vectors containing the polynucleotides.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 7, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Klaus Bosslet, Peter Pfleiderer, Gerhard Seemann
  • Granulocyte-binding antibody constructs, their preparation and use
    Patent number: 5645817
    Abstract: The present invention describes granulocyte-binding antibody constructs, which were derived from the monoclonal mouse antibody MAk BW 250/183 (EP-A1-0 388 914), as well as a process for their preparation and their use.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: July 8, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Gerhard Seemann, Klaus Bosslet
  • Monoclonal antibodies against tumor-associated antigens
    Patent number: 5639621
    Abstract: The invention relates to monoclonal antibodies against a tumor-associated antigen which is mainly derived from tumors from the group of carcinomas of the breast, ovaries and prostate, as well as adenocarcinomas of the lung, which additionally react with polymorphic epithelial mucin (PEM), to the preparation and use thereof and to the use of the epitope defined by the antibody for diagnosis and therapy.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 17, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Klaus Bosslet, Peter Pfleiderer, Gerhard Seemann
  • Bispecific and oligospecific mono-and oligovalent receptors, the preparation and use thereof
    Patent number: 5591828
    Abstract: The invention relates to bispecific and oligospecific, mono- and oligovalent receptors which are prepared by gene manipulation by fusion of DNA coding for F(ab) fragments of antibodies of two or more different specificities by means of suitable linkers. In this connection, one specificity is preferably directed either against an epitope, which is located on the cell membrane or in the interstitium, of a tumor-associated antigen (TAA) or against an epitope in the tumor endothelium (TE), while the other specificities relate to high-molecular or low-molecular weight ligands and react, for example, with the Komplexons ethylenediaminetetraacetate and diethylenetriaminepentaacetate in Y90 complexed form (EDTA-Y90 and DTPA-Y90 respectively). In a particularly preferred embodiment, the binding with the Komplexons takes place on the Komplexon receptor arm via fos-jun interaction (or else avidin-biotin interaction). Other preferred specificities have catalytic properties.
    Type: Grant
    Filed: September 29, 1994
    Date of Patent: January 7, 1997
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Klaus Bosslet, Peter Hermentin, Gerhard Seemann, Ludwig Kuhlmann, Axel Steinstr asser
  • Glycosylated prodrugs, their method of preparation and their uses
    Patent number: 5561119
    Abstract: Glycosylated prodrugs, a preparation method therefor, and their use with tumor-specific immunoenzymatic conjugates for the treatment of cancer, are described. These anthracycline prodrugs have formula (I).
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: October 1, 1996
    Assignees: Laboratoires Hoechst, Behringwerke A.G.
    Inventors: Jean-Claude Jacquesy, Jean-Pierre Gesson, Claude Monneret, Martine Mondon, Brigitte Renoux, Jean-Claude Florent, Michel Koch, Fran.cedilla.ois Tillequin, Hans H. Sedlacek, Manfred Gerken, Cenek Kolar, Gilbert Gaudel, Klaus Bosslet, J org Czech, Dieter Hoffman, Gerhard Seemann, Hans-Ulrich Schorlemmer, Gerhard Dickneite