Abstract: The present invention relates to uses of granulocyte colony stimulating factor (GCSF) or fragment thereof for the preparation of a pharmaceutical composition for treating organ dysfunction caused by ischemia, whereby the pharmaceutical composition is to be administered to a patient who is subjected to a surgical or interventional procedure in order to improve organ function, to improve organ function, to improve blood flow and/or to induce revascularization. Furthermore, the present invention relates to methods of treating organ dysfunction caused by ischemia comprising administering a therapeutically effective amount of G-CSF or fragment thereof to a patient who is subjected to a surgical or interventional procedure in order to improve organ function, to improve organ function, to improve blood flow and/or to induce revascularization.

Abstract: Several hundred digitized ECG waveforms are averaged together (discarding abnormal waveforms) to form an array of digitized values. Then multiple overlapping subsegments are extracted from this array, processed by a window function in a way that produces a D.C. free result, and transformed into the frequency domain. The logarithm of the square of the amplitude (down to a minimum noise threshold level) of these frequency domain values are then plotted in a three-dimensional plot that graphically illustrates whether or not the patient from whom the waveforms were taken is likely to be at risk of cardiac arrhythmia in the near future. Cross correlation of these functions against one far removed from the QRS complex enables a factor of normality to be computed.