Abstract: Pre-filled syringes include an elastic and sliding valvular joint acting as a temporary closure to prevent internal chamber(s) from communicating with the outside (or between chambers). The joint includes two discoid cooperative elements: an elastic discoid cap and a sliding receiving discoid seat that has a central passage tube. The cap includes an elastic base from which a compact closing cylinder protrudes. The closing cylinder has a distal area with a plurality of longitudinal grooves. The cap can: (a) half-fit the central tube of the receiving discoid seat, which will allow the communication of fluid through the plurality of grooves, and (b) seal the chamber by completely fitting the central tube of the receiving discoid seat. Accordingly, the half-fit position allows the lyophilization of contents of the syringe.

Abstract: An elastic and sliding valvular joint for pre-filled syringes, which comprises a single chamber with an injectable product or two chambers that contain isolated products to be mixed before the injection is described. The valvular joint acts as a temporary closure, which prevents the internal chamber from communicating with the outside, or between both internal chambers. The joint comprises two discoid cooperative elements arranged on the syringe and with its edge against the internal surface: an elastic discoid plug and a sliding receiving discoid seat. The receiving discoid seat includes a central passage tube facing the hollow cylinder, and the elastic base of the plug fits in a removable manner inside a cylindrical cavity of the opening of the central passage tube of the seat.

Abstract: An elastic and sliding valvular joint for pre-filled syringes, which comprises a single chamber with an injectable product or two chambers that contain isolated products to be mixed before the injection is described. The valvular joint acts as a temporary closure, which prevents the internal chamber from communicating with the outside, or between both internal chambers. The joint comprises two discoid cooperative elements arranged on the syringe and with its edge against the internal surface: an elastic discoid plug and a sliding receiving discoid seat. The receiving discoid seat includes a central passage tube facing the hollow cylinder, and the elastic base of the plug fits in a removable manner inside a cylindrical cavity of the opening of the central passage tube of the seat.