Patents by Inventor Gerold Endert
Gerold Endert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9737484Abstract: A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.Type: GrantFiled: November 12, 2014Date of Patent: August 22, 2017Assignee: Marina Biotech, Inc.Inventors: Steffen Panzner, Yvonne Kerwitz, Una Rauchhaus, Silke Lutz, Gerold Endert
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Patent number: 9668973Abstract: The invention suggests amphoteric lipids wherein one or more amphoteric groups having an isoelectric point between 4 and 9 are substituted on a membranous or membrane-forming amphiphilic substance, as well as liposomes containing such compounds.Type: GrantFiled: October 11, 2013Date of Patent: June 6, 2017Assignee: Marina Biotech, Inc.Inventors: Frank Essler, Steffen Panzner, Gerold Endert
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Publication number: 20150231073Abstract: A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.Type: ApplicationFiled: November 12, 2014Publication date: August 20, 2015Inventors: Steffen Panzner, Yvonne Kerwitz, Una Rauchhaus, Silke Lutz, Gerold Endert
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Patent number: 9066867Abstract: A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.Type: GrantFiled: September 9, 2010Date of Patent: June 30, 2015Assignee: Marina Biotech, Inc.Inventors: Steffen Panzner, Yvonne Kerwitz, Una Rauchhaus, Silke Lutz, Gerold Endert
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Publication number: 20150118291Abstract: The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer.Type: ApplicationFiled: December 12, 2014Publication date: April 30, 2015Inventors: Neal Clifford Goodwin, Gerold Endert, Natalie Herzog, Yvonne Kerwitz, Steffen Panzner, Wendi Rodrigueza
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Publication number: 20140227345Abstract: The invention suggests amphoteric lipids wherein one or more amphoteric groups having an isoelectric point between 4 and 9 are substituted on a membranous or membrane-forming amphiphilic substance, as well as liposomes containing such compounds.Type: ApplicationFiled: October 11, 2013Publication date: August 14, 2014Applicant: Marina Biotech, Inc.Inventors: Frank Essler, Steffen Panzner, Gerold Endert
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Publication number: 20140056970Abstract: A method for preparing amphoteric liposomes loaded with a polyanionic active agent as cargo, characterised by admixing an aqueous solution of said polyanionic active agent and an alcoholic solution of one or more amphiphiles and buffering said admixture to an acidic pH, said one or more amphiphiles being susceptible of forming amphoteric liposomes at said acidic pH, thereby to form such amphoteric liposomes in suspension encapsulating said active agent under conditions such that said liposomes form aggregates, and thereafter treating said suspension to dissociate said aggregates. Also disclosed are nucleic acid loaded amphoteric liposomes produced in accordance with the method, wherein said nucleic acids are oligonucleotides and said liposomes are multilamellar.Type: ApplicationFiled: October 29, 2013Publication date: February 27, 2014Applicant: Marina Biotech, Inc.Inventors: Steffen Panzner, Gerold Endert, Una Rauchhaus, Natalie Herzog, Claudia Muller
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Publication number: 20130323298Abstract: The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer.Type: ApplicationFiled: January 28, 2013Publication date: December 5, 2013Applicants: Novosom AG, ProNAi Therapeutics, Inc.Inventors: Neal Clifford Goodwin, Gerold Endert, Natalie Herzog, Yvonne Kerwitz, Steffen Panzner, Wendi Rodrigueza
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Patent number: 8580297Abstract: The invention suggests amphoteric lipids wherein one or more amphoteric groups having an isoelectric point between 4 and 9 are substituted on a membranous or membrane-forming amphiphilic substance, as well as liposomes containing such compounds.Type: GrantFiled: November 8, 2011Date of Patent: November 12, 2013Assignee: Marina Biotech, Inc.Inventors: Frank Essler, Steffen Panzner, Gerold Endert
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Patent number: 8367628Abstract: The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer.Type: GrantFiled: December 1, 2006Date of Patent: February 5, 2013Assignees: ProNAi Therapeutics, Inc., Novosom AGInventors: Neal Clifford Goodwin, Gerold Endert, Natalie Herzog, Yvonne Kerwitz, Steffen Panzner, Wendi Rodrigueza
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Patent number: 8236770Abstract: The invention relates to amphoteric liposomal formulations which are provided with great serum stability and are suitable for the intracellular delivery of oligonucleotides.Type: GrantFiled: March 29, 2005Date of Patent: August 7, 2012Assignee: Marina Biotech, Inc.Inventors: Gerold Endert, Yvonne Kerwitz, Monika Fellermeier
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Patent number: 8192753Abstract: The invention suggests a pH-sensitive cationic lipid with a pKa value between 3.5 and 8, according to the general formula cation-spacer-Y-spacer-X-lipid, wherein Y and X represent linking groups. Furthermore, liposomes are described, which liposomes include said optionally cationic lipids.Type: GrantFiled: February 19, 2003Date of Patent: June 5, 2012Assignee: Marina Biotech, Inc.Inventors: Frank Essler, Steffen Panzner, Gerold Endert
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Publication number: 20120100205Abstract: The invention suggests amphoteric lipids wherein one or more amphoteric groups having an isoelectric point between 4 and 9 are substituted on a membranous or membrane-forming amphiphilic substance, as well as liposomes containing such compounds.Type: ApplicationFiled: November 8, 2011Publication date: April 26, 2012Inventors: Frank ESSLER, Steffen PANZNER, Gerold ENDERT
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Publication number: 20120021042Abstract: A method for preparing amphoteric liposomes loaded with polyanionic active agent as cargo, characterised by admixing an aqueous solution of said polyanionic active agent and an alcoholic solution of one or more amphiphiles and buffering said admixture to an acidic pH, said one or more amphiphiles being susceptible of forming amphoteric liposomes at said acidic pH, thereby to form such amphoteric liposomes in suspension encapsulating said active agent under conditions such that said liposomes form aggregates, and thereafter treating said suspension to dissociate said aggregates. Also disclosed are nucleic acid loaded amphoteric liposomes produced in accordance with the method, wherein said nucleic acids are oligonucleotides and said liposomes are multilamellar.Type: ApplicationFiled: March 16, 2007Publication date: January 26, 2012Inventors: Steffen Panzner, Gerold Endert, Una Rauchhaus, Natalie Herzog, Claudia Muller
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Publication number: 20110293695Abstract: Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.Type: ApplicationFiled: August 9, 2010Publication date: December 1, 2011Applicant: NOVOSOM AGInventors: Steffen Panzner, Stefan Fankh+e,uml a+ee nel, Frank Essler, Cornelia Panzner, Gerold Endert
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Publication number: 20110076322Abstract: A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.Type: ApplicationFiled: September 9, 2010Publication date: March 31, 2011Inventors: Steffen Panzner, Yvonne Kerwitz, Una Rauchhaus, Silke Lutz, Gerold Endert
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Patent number: 7858117Abstract: Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.Type: GrantFiled: May 7, 2007Date of Patent: December 28, 2010Assignee: Novosom AGInventors: Steffen Panzner, Stefan Fankhaenel, Frank Essler, Cornelia Panzner, Gerold Endert
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Patent number: 7780983Abstract: Amphoteric liposomes are proposed, which comprise positive and negative membrane-based or membrane-forming charge carriers as well as the use of these liposomes.Type: GrantFiled: October 31, 2006Date of Patent: August 24, 2010Assignee: Novosom AGInventors: Steffen Panzner, Stefan Fankhänel, Frank Essler, Cornelia Panzner, Gerold Endert
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Patent number: 7763275Abstract: A method for the production of nano- or microcapsules having a diameter of from 20 nm to 40 ?m is suggested, wherein template particles are supplied in an aqueous medium, electrically recharged with a polyelectrolyte, re-recharged without separation or washing steps using a second polyelectrolyte having a complementary charge with respect to the first polyelectrolyte, and said process is optionally continued with alternately charged polyelectrolytes.Type: GrantFiled: March 2, 2001Date of Patent: July 27, 2010Assignee: Novosom AGInventors: Steffen Panzner, Gerold Endert, Frank Essler, Anja Behrens, Silke Lutz, Cornelia Panzner
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Publication number: 20090220584Abstract: The invention relates to compositions and methods to inhibit gene expression. In particular, the invention provides DNAi oligonucleotides sequestered by amphoteric liposomes for the treatment of cancer.Type: ApplicationFiled: December 1, 2006Publication date: September 3, 2009Inventors: Neal Clifford Goodwin, Gerold Endert, Natalie Herzog, Yvonne Kerwitz, Steffen Panzner, Wendi Rodrigueza