Abstract: A method, a system, and a computer program product for detecting and/or determining occurrence of a neurological event in a subject. Data corresponding to one or more symptoms, detected by one or more sensors, associated with a subject is received. The sensors include sensors positioned directly on the subject and/or sensors positioned away from the subject. One or more symptom values are assigned to one or more detected symptoms. A severity score for each of the symptoms is determined. The severity scores are determined using one or more machine learning models receiving the assigned symptom values as input. A prediction that the subject is experiencing at least one neurological event and at least a type of the neurological event is generated using a combination of the determined severity scores corresponding to the symptoms. A generation of one or more alerts is triggered based on the prediction. One or more user interfaces are generated for displaying the alerts.

Abstract: A system and a method for recording neural signals. A neural interface system-on-chip for recoding the signals includes one or more electrodes integrated on a complimentary metal-oxide-semiconductor integrated circuit and coupled to one or more corresponding analog front end components. The analog front end components are configured to be programmable for recording one or more neural signals and to operate in at least one of the following selectable programmable modes: a voltage clamp mode and a current clamp mode. The neural interface system-on-chip also includes one or more analog to digital converter components that are coupled to the electrodes.

Abstract: Apparatuses and methods are disclosed for efficient wireless powering of an electrical load with precise external control over pulsed voltage waveform and metering of charge delivered. The system interfaces to an inductive coil for RF power delivery from an external duty-cycled RF power transmitter, and the electrical load. The electrical load may be a photosensitive array of electrodes for an optically addressed, electrically activated retinal prosthesis. The voltage waveform to activate the load is controlled by the transmitted RF amplitude, including switching between cathodic and anodic phases of electrical stimulation. Charge delivered to the load is quantified as discharge events through a series capacitor, transmitted by backtelemetry to the receiver for continuous monitoring throughout the stimulation phases.

Abstract: A compute-in-memory neural network architecture combines neural circuits implemented in CMOS technology and synaptic conductance crossbar arrays. The crossbar memory structures store the weight parameters of the neural network in the conductances of the synapse elements, which define interconnects between lines of neurons of consecutive layers in the network at the crossbar intersection points.

Abstract: The multimodal query-driven imager provides efficient coding and streaming of visual information acquired directly on the focal plane. The query-driven approach to visual event coding uses clocked time-division multiplexing to continuously scan the array, querying each pixel for threshold change events in pixel intensity.

Abstract: An apparatus for wireless power transfer is described. In some implementations, the apparatus includes a resonant circuit configured to receive a radio frequency input and generate an in-phase voltage and an out-of-phase voltage. The apparatus further includes a pulse generation circuit configured to at least gate the in-phase voltage to provide a first output voltage, and gate the out-of-phase voltage to provide a second output voltage. The apparatus further includes a pulse width modulation circuit configured to provide, to the pulse generating circuit, information for controlling the pulse width modulation setting. The apparatus further includes a pulse frequency modulation circuit configured to provide, to the pulse generating circuit, information for controlling the pulse frequency modulation setting, the information for controlling the pulse frequency modulation setting determined based on the pulse width modulation setting. Related systems, methods, and articles of manufacture are also described.

Abstract: In one respect, there is provided an apparatus for neural stimulation. The apparatus may include an antenna, a plurality of electrodes, and a voltage supply generator. The antenna may be configured to receive, from an external source, radio frequency energy. The voltage supply generator configured to generate a voltage supply by at least ramping up a voltage of the radio frequency energy in successive increments, wherein the voltage supply drives a current to the plurality of electrodes during neural stimulation. Related methods and computer program products are also disclosed.

Abstract: An integrated nanowire device includes a first array of nanowires having a first set of characteristics and a second array of nanowires having a second set of characteristics. A processor is electrical communication with the first and second arrays of nanowires receives the first plurality of charges and generate a processor signal therefrom. The second array of nanowires may be configured to produce a stimulation current in response to the processor signal. The first or second array may be used to generate power for operation of the device, or the arrays may function as a stimulator, sensor combination to enable the device to self-regulate based on localized responses to stimulation. The device may be implanted for use as a neural stimulator.

Abstract: An apparatus may include a delta sigma modulator. A first portion of the delta sigma modulator may form a digital predictor while a second portion of the delta sigma modulator may form an analog approximator. An output of the analog approximator may be coupled with a quantizer. The digital predictor, the analog approximator, and the quantizer may form a digitizing loop configured to convert an analog input into a digital output. The digital predictor may be configured to generate, based on a polarity of one or more digital outputs from the quantizer, a digital prediction of an expected amplitude of the analog input. The quantizer may be configured to respond to the digital prediction by adjusting a dynamic range of the digitizing loop including by changing a quantization step size used by the quantizer to quantize the analog input. Related methods are also provided.

Abstract: The multimodal query-driven imager provides efficient coding and streaming of visual information acquired directly on the focal plane. The query-driven approach to visual event coding uses clocked time-division multiplexing to continuously scan the array, querying each pixel for threshold change events in pixel intensity.

Abstract: An apparatus may include a delta sigma modulator. A first portion of the delta sigma modulator may form a digital predictor while a second portion of the delta sigma modulator may form an analog approximator. An output of the analog approximator may be coupled with a quantizer. The digital predictor, the analog approximator, and the quantizer may form a digitizing loop configured to convert an analog input into a digital output. The digital predictor may be configured to generate, based on a polarity of one or more digital outputs from the quantizer, a digital prediction of an expected amplitude of the analog input. The quantizer may be configured to respond to the digital prediction by adjusting a dynamic range of the digitizing loop including by changing a quantization step size used by the quantizer to quantize the analog input. Related methods are also provided.

Abstract: An apparatus for wireless power transfer is described. In some implementations, the apparatus includes a resonant circuit configured to receive a radio frequency input and generate an in-phase voltage and an out-of-phase voltage. The apparatus further includes a pulse generation circuit configured to at least gate the in-phase voltage to provide a first output voltage, and gate the out-of-phase voltage to provide a second output voltage. The apparatus further includes a pulse width modulation circuit configured to provide, to the pulse generating circuit, information for controlling the pulse width modulation setting. The apparatus further includes a pulse frequency modulation circuit configured to provide, to the pulse generating circuit, information for controlling the pulse frequency modulation setting, the information for controlling the pulse frequency modulation setting determined based on the pulse width modulation setting. Related systems, methods, and articles of manufacture are also described.

Abstract: In one respect, there is provided an apparatus for neural stimulation. The apparatus may include an antenna, a plurality of electrodes, and a voltage supply generator. The antenna may be configured to receive, from an external source, radio frequency energy. The voltage supply generator configured to generate a voltage supply by at least ramping up a voltage of the radio frequency energy in successive increments, wherein the voltage supply drives a current to the plurality of electrodes during neural stimulation. Related methods and computer program products are also disclosed.

Abstract: Systems, methods, and articles of manufacture, including computer program products, are provided for capacitive passive mixer baseband receivers with broadband harmonic rejection. In some embodiments, an apparatus is provided. The apparatus includes a receiver configured to receive an input signal and generate, based on the input signal, an in-phase portion and a quadrature phase portion. The apparatus further includes a harmonic rejection mixer comprising a plurality of capacitors, the plurality of capacitors encoded with a plurality of capacitance values, the harmonic rejection mixer configured to reduce harmonics in the input signal based on applying a quantity of the plurality of capacitance values to the input signal. The apparatus further includes a plurality of switches configured to activate the plurality of capacitors, the quantity of the plurality of predetermined capacitance values applied to the input signal based on a quantity of the plurality of capacitors that are active.

Abstract: A telemetry device includes a resonant inductive link with a primary LC tank and secondary LC tank configured to resonate at a carrier frequency. A modulator assembly in communication with the secondary LC tank implements data-synchronized cyclic on-off keying modulation (COOK) to periodically create a short across the secondary LC tank in response to a pulse from a phase selector and phase-locked loop. During the full cycle-length of the short, data can be transmitted across the inductive link while the charge across the secondary LC tank is preserved. Power may be transferred across the link during non-shorted cycles.

Abstract: A real-time multi-channel EEG signal processor based on an on-line recursive independent component analysis is provided. A whitening unit generates covariance matrix by computing covariance according to a received sampling signal. A covariance matrix generates a whitening matrix by a computation of an inverse square root matrix calculation unit. An ORICA calculation unit computes the sampling signal and the whitening matrix to obtain a post-whitening sampling signal. The post-whitening sampling signal and an unmixing matrix implement an independent component analysis computation to obtain an independent component data. An ORICA training unit implements training of the unmixing matrix according to the independent component data to generate a new unmixing matrix. The ORICA calculation unit may use the new unmixing matrix to implement an independent component analysis computation. Hardware complexity and power consumption can be reduced by sharing registers and arithmetic calculation units.

Abstract: Systems, methods, and articles of manufacture, including computer program products, are provided for capacitive passive mixer baseband receivers with broadband harmonic rejection. In some embodiments, an apparatus is provided. The apparatus includes a receiver configured to receive an input signal and generate, based on the input signal, an in-phase portion and a quadrature phase portion. The apparatus further includes a harmonic rejection mixer comprising a plurality of capacitors, the plurality of capacitors encoded with a plurality of capacitance values, the harmonic rejection mixer configured to reduce harmonics in the input signal based on applying a quantity of the plurality of capacitance values to the input signal. The apparatus further includes a plurality of switches configured to activate the plurality of capacitors, the quantity of the plurality of predetermined capacitance values applied to the input signal based on a quantity of the plurality of capacitors that are active.

Abstract: A telemetry device includes a resonant inductive link with a primary LC tank and secondary LC tank configured to resonate at a carrier frequency. A modulator assembly in communication with the secondary LC tank implements data-synchronized cyclic on-off keying modulation (COOK) to periodically create a short across the secondary LC tank in response to a pulse from a phase selector and phase-locked loop. During the full cycle-length of the short, data can be transmitted across the inductive link while the charge across the secondary LC tank is preserved. Power may be transferred across the link during non-shorted cycles.

Abstract: A prosthetic retina for implantation in an eye having a defective retina is formed from an array of nanowires having a predetermined spatial distribution, density, size and shape implanted in close proximity to the retina. An electrical conductor is formed at a first end of all nanowires in the array of nanowires and placed in contact with a bias source which biases the array. A plurality of electrodes is located on a second end of each of one nanowire or a bundle of nanowires in the array. Each nanowire produces a photocurrent at a corresponding electrode in response to detection of light impinging on the array of nanowires and the photocurrent stimulates one or more neurons adapted for visual perception. In the preferred embodiment, the predetermined spatial distribution mimics a distribution of rods and cones in a normal eye.

Abstract: An electric field sensor includes one or more sensing electrodes connected to an integrated amplifier that bootstraps all parasitic capacitances at the sensor input to provide for a very high input impedance without the need for neutralization or other adjustments and calibration. The integrated amplifier for the electric field sensor further includes low-noise ESD/biasing structures to stabilize the DC-potential of the sensor with a minimum amount of added noise, leakage and parasitic capacitance.