Patents by Inventor Gholamreza Javahery
Gholamreza Javahery has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10622200Abstract: Certain configurations of ionization sources are described. In some examples, an ionization source comprises an ionization block, an electron source, an electron collector, an ion repeller and at least one electrode configured to provide an electric field when a voltage is provided to the at least one electrode. Systems and methods using the ionization source are also described.Type: GrantFiled: May 18, 2018Date of Patent: April 14, 2020Assignee: PerkinElmer Health Sciences Canada, Inc.Inventors: Anna Kornilova, Gholamreza Javahery, Lisa Cousins
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Publication number: 20190355566Abstract: Certain configurations of ionization sources are described. In some examples, an ionization source comprises an ionization block, an electron source, an electron collector, an ion repeller and at least one electrode configured to provide an electric field when a voltage is provided to the at least one electrode. Systems and methods using the ionization source are also described.Type: ApplicationFiled: May 18, 2018Publication date: November 21, 2019Inventors: Anna Kornilova, Gholamreza Javahery, Lisa Cousins
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Publication number: 20190355565Abstract: Certain configurations of plasma discharge chambers and plasma ionization sources comprising a plasma discharge chamber are described. In some examples, the discharge chamber comprises a conductive area and is configured to sustain a plasma discharge within the discharge chamber. In other examples, the discharge chamber comprises at least one inlet configured to receive a plasma gas and at least one outlet configured to provide ionized analyte from the discharge chamber. Systems and methods using the discharge chambers are also described.Type: ApplicationFiled: May 10, 2019Publication date: November 21, 2019Inventors: Mehrnaz Sarrafzadeh, Gholamreza Javahery, Charles Jolliffe, Lisa Cousins
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Publication number: 20190341241Abstract: An ionizer includes a probe having multiple coaxially aligned conduits. The conduits may carry liquids, and nebulizing and heating gases at various flow rates and temperatures, for generation of ions from a liquid source. An outermost conduit defines an entrainment region that transports and entrains ions in a gas for a defined distance along the length of the conduits. In embodiments, various voltages may be applied to the multiple conduits to aid in ionization and to guide ions. Depending on the voltages applied to the multiple conduits and electrodes, the ionizer can act as an electrospray, APCI, or APPI source. Further, the ionizer may include a source of photons or a source of corona ionization. Formed ions may be provided to a downstream mass analyser.Type: ApplicationFiled: May 3, 2018Publication date: November 7, 2019Inventors: Frenny Kaushal, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
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Publication number: 20190326109Abstract: A mass analyzer includes two chambers for ionizing gas to form ions and/or introducing reaction gases to aid in ionization. A first chamber includes an electron to allow electron bombardment of a first gas. A second chamber receives a second gas and ions from the first chamber to allow interaction between the second gas, and the ions from the first chamber. The first and/or second gas may include analyte.Type: ApplicationFiled: April 20, 2018Publication date: October 24, 2019Inventors: Heather GAMBLE, Gholamreza JAVAHERY, Lisa COUSINS, Charles JOLLIFFE
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Publication number: 20190189417Abstract: An ion source comprising a chamber and an electron collector is described. In one configuration, the chamber comprises a sample inlet and an ion outlet. The chamber may also include an electron inlet configured to receive electrons from an electron source. The electron collector can be arranged in opposition to the electron inlet. The chamber can be configured to direct an electron beam from the electron source along a path with the chamber transverse to a path between the gas inlet and the ion outlet. The chamber may comprise an ion guide that includes a guide axis offset from an axis of the ion outlet.Type: ApplicationFiled: September 29, 2018Publication date: June 20, 2019Inventors: Heather Gamble, Gholamreza Javahery, Lisa Cousins, Charles Jolliffe
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Patent number: 9916969Abstract: A mass analyzer includes a desolvation chamber into which an upstream gas is injected to provide a counter-flow to said downstream flow in the chamber. The counter-flow may slow the downstream flow of solvated ionized particles in the chamber, while allowing lighter desolvated ions to travel toward an outlet aperture of the desolvation chamber.Type: GrantFiled: January 14, 2013Date of Patent: March 13, 2018Assignee: PerkinElmer Health Sciences Canada, Inc.Inventors: Charles Jolliffe, Lisa Cousins, Gholamreza Javahery
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Patent number: 9449803Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.Type: GrantFiled: December 17, 2014Date of Patent: September 20, 2016Assignee: PERKINELMER HEALTH SCIENCES CANADA, INC.Inventors: Charles Jolliffe, Gholamreza Javahery, Lisa Cousins
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Patent number: 9343280Abstract: A mass spectrometer includes a plurality of guide stages for guiding ions between an ion source and an ion detector along a guide axis. Each of the guide stages is contained within one of a plurality of adjacent chambers. Pressure in each of the plurality of chambers is reduced downstream along the guide axis to guide ions along the axis. Each guide stage may further include a plurality of guide rods for producing a containment filed for containing ions about the guide axis, as they are guided to the detector.Type: GrantFiled: September 8, 2008Date of Patent: May 17, 2016Assignee: PerkinElmer Health Sciences Canada, Inc.Inventors: Lisa Cousins, Gholamreza Javahery, Charles Jolliffe, Serguei Savtchenko
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Publication number: 20150311053Abstract: Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the airflow travelling through the desorption channel. An ionizer forms ions from vapour molecules in the portion of the airflow. At least one mass spectrometer analyzes the ions to detect the target substance. The airflow travels without interruption from the subject to the at least one mass spectrometer. The desorption channel causes a sufficient quantity of molecules to desorb from the analyte to enable the at least one mass spectrometer to detect the target substance.Type: ApplicationFiled: May 4, 2015Publication date: October 29, 2015Inventors: WILLIAM R. STOTT, GHOLAMREZA JAVAHERY
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Publication number: 20150214021Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.Type: ApplicationFiled: December 17, 2014Publication date: July 30, 2015Inventors: Charles Jolliffe, Gholamreza Javahery, Lisa Cousins
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Patent number: 9048076Abstract: Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the airflow travelling through the desorption channel. An ionizer forms ions from vapor molecules in the portion of the airflow. At least one mass spectrometer analyzes the ions to detect the target substance. The flow travels without interruption from the subject to the at least one mass spectrometer. The desorption channel causes a sufficient quantity of molecules to desorb from the analyte to enable the at least one mass spectrometer to detect the target substance.Type: GrantFiled: May 25, 2012Date of Patent: June 2, 2015Assignee: MSDetection Corp.Inventors: William R. Stott, Gholamreza Javahery
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Patent number: 8981290Abstract: Apparatus and methods are provided that enable the interaction of low energy electrons and positrons with sample ions to facilitate electron capture dissociation (EGO) and positron capture dissociation (PGO), respectively, within multipole ion guide structures.Type: GrantFiled: March 28, 2014Date of Patent: March 17, 2015Assignee: PerkinElmer Health Sciences, Inc.Inventors: Craig M. Whitehouse, David G. Welkie, Gholamreza Javahery, Lisa Cousins, Sergey Rakov
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Patent number: 8946622Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.Type: GrantFiled: August 29, 2013Date of Patent: February 3, 2015Assignee: Ionics Mass Spectrometry Group, Inc.Inventors: Charles Jolliffe, Gholamreza Javahery, Lisa Cousins
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Publication number: 20140209814Abstract: Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices.Type: ApplicationFiled: March 28, 2014Publication date: July 31, 2014Applicant: PerkinElmer Health Sciences, Inc.Inventors: Craig M. Whitehouse, David G. Welkie, Gholamreza Javahery, Lisa Cousins, Sergey Rakov
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Publication number: 20140197333Abstract: A mass analyzer includes a desolvation chamber into which an upstream gas is injected to provide a counter-flow to said downstream flow in the chamber. The counter-flow may slow the downstream flow of solvated ionized particles in the chamber, while allowing lighter desolvated ions to travel toward an outlet aperture of the desolvation chamber.Type: ApplicationFiled: January 14, 2013Publication date: July 17, 2014Applicant: Ionics Mass Spectrometry Group Inc.Inventors: Charles Jolliffe, Lisa Cousins, Gholamreza Javahery
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Publication number: 20140117223Abstract: Methods and devices for detecting a target substance on a subject without contacting the subject are disclosed. At least one air jet blows analyte from a surface of the subject into an airflow, the airflow entraining the analyte. A desorption channel desorbs molecules from analyte in a portion of the airflow travelling through the desorption channel. An ionizer forms ions from vapour molecules in the portion of the airflow. At least one mass spectrometer analyzes the ions to detect the target substance. The flow travels without interruption from the subject to the at least one mass spectrometer. The desorption channel causes a sufficient quantity of molecules to desorb from the analyte to enable the at least one mass spectrometer to detect the target substance.Type: ApplicationFiled: May 25, 2012Publication date: May 1, 2014Applicant: MSDETECTION CORP.Inventors: William R. Stott, Gholamreza Javahery
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Patent number: 8686356Abstract: Apparatus and methods are provided that enable the interaction of low energy electrons and positrons with sample ions to facilitate electron capture dissociation (EGO) and positron capture dissociation (PGO), respectively, within multipole ion guide structures. The apparatus and methods described herein allow EGO (and PCO) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods.Type: GrantFiled: December 13, 2012Date of Patent: April 1, 2014Assignee: PerkinElmer Health Sciences, Inc.Inventors: Craig M. Whitehouse, David G. Welkie, Gholamreza Javahery, Lisa Cousins, Sergey Rakov
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Publication number: 20140087478Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.Type: ApplicationFiled: August 29, 2013Publication date: March 27, 2014Applicant: Ionics Mass Spectrometry Group Inc.Inventors: Charles Jolliffe, Gholamreza Javahery, Lisa Cousins
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Patent number: 8546750Abstract: A mass spectrometer interface, having improved sensitivity and reduced chemical background, is disclosed. The mass spectrometer interface provides improved desolvation, chemical selectivity and ion transport. A flow of partially solvated ions is transported along a tortuous path into a region of disturbance of flow, where ions and neutral molecules collide and mix. Thermal energy is applied to the region of disturbance to promote liberation of at least some of the ionized particles from any attached impurities, thereby increasing the concentration of the ionized particles having the characteristic m/z ratios in the flow. Molecular reactions and low pressure ionization methods can also be performed for selective removal or enhancement of particular ions.Type: GrantFiled: June 27, 2008Date of Patent: October 1, 2013Assignee: Ionics Mass Spectrometry Group, Inc.Inventors: Charles Jolliffe, Gholamreza Javahery, Lisa Cousins