Patents by Inventor Gil Ben-Menachem

Gil Ben-Menachem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR CONJUGATION OF OLIGOSACCHARIDES OR POLYSACCHARIDES TO PROTEIN CARRIERS THROUGH OXIME LINKAGES VIA 3-DEOXY-D-MANNO-OCTULSONIC ACID
    Publication number: 20140378669
    Abstract: Methods for preparing an oligosaccharide—protein carrier immunogenic conjugate or a polysaccharide—protein carrier immunogenic conjugate. The methods include obtaining an oligosaccharide or polysaccharide having a KDO moiety located at the terminal reducing end of the oligosaccharide or polysaccharide that includes a carbonyl functional group; and reacting the carbonyl functional group of the KDO moiety with an aminooxylated protein carrier molecule resulting in a conjugate that includes a covalent oxime bond between the oligosaccharide and the protein carrier or the polysaccharide and the protein carrier.
    Type: Application
    Filed: June 26, 2014
    Publication date: December 25, 2014
    Applicants: The U.S.A , as represented by the Secretary, Department of Health and Human Services, National Research Council of Canada
    Inventors: Joanna Kubler-Kielb, Vince Pozsgay, Teresa Langergard, Gil Ben-Menachem, Rachel Schneerson, Ariel Ginzberg, Evguenii Vinogradov
  • Methods for conjugation of oligosaccharides or polysaccharides to protein carriers through oxime linkages via 3-deoxy-D-manno-octulsonic acid
    Patent number: 8795680
    Abstract: Methods for preparing an oligosaccharide-protein carrier immunogenic conjugate or a polysaccharide-protein carrier immunogenic conjugate. The methods include obtaining an oligosaccharide or polysaccharide having a KDO moiety located at the terminal reducing end of the oligosaccharide or polysaccharide that includes a carbonyl functional group; and reacting the carbonyl functional group of the KDO moiety with an aminooxylated protein carrier molecule resulting in a conjugate that includes a covalent oxime bond between the oligosaccharide and the protein carrier or the polysaccharide and the protein carrier.
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: August 5, 2014
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, National Research Council of Canada
    Inventors: Joanna Kubler-Kielb, Vince Pozsgay, Teresa Lagergard, Gil Ben-Menachem, Rachel Schneerson, Evguenii Vinogradov, Ariel Ginzberg
  • METHODS FOR CONJUGATION OF OLIGOSACCHARIDES OR POLYSACCHARIDES TO PROTEIN CARRIERS THROUGH OXIME LINKAGES VIA 3-DEOXY-D-MANNO-OCTULSONIC ACID
    Publication number: 20100158937
    Abstract: Methods for preparing an oligosaccharide-protein carrier immunogenic conjugate or a polysaccharide-protein carrier immunogenic conjugate. The methods include obtaining an oligosaccharide or polysaccharide having a KDO moiety located at the terminal reducing end of the oligosaccharide or polysaccharide that includes a carbonyl functional group; and reacting the carbonyl functional group of the KDO moiety with an aminooxylated protein carrier molecule resulting in a conjugate that includes a covalent oxime bond between the oligosaccharide and the protein carrier or the polysaccharide and the protein carrier.
    Type: Application
    Filed: July 18, 2007
    Publication date: June 24, 2010
    Inventors: Joanna Kubler-Kielb, Vince Pozsgay, Teresa Lagergard, Gil Ben-Menachem, Rachel Schneerson, Evguenii Vinogradov, Ariel Ginzberg
  • CHOLESTEROL-CONTAINING COMPOUNDS AND THEIR USE AS IMMUNOGENS AGAINST BORRELIA BURGDORFERI
    Publication number: 20100062023
    Abstract: Unique compounds that can be used for inducing an immune response to Borrelia burgdorferi in a subject by administering a therapeutically effective amount of the glycolipid to the subject. Such administration is particularly useful for preventing or treating Lyme disease in a subject. The compounds(s), and therapeutically acceptable salts thereof, may be formulated into pharmaceutical or immunogenic compositions.
    Type: Application
    Filed: July 29, 2009
    Publication date: March 11, 2010
    Inventors: Gil Ben-Menachem, Joanna Kubler-Kielb, Rachel Schneerson, John B. Robbins, Vince Pozsgay
  • Cholesterol-containing compounds and their use as immunogens against
    Patent number: 7666846
    Abstract: Unique compounds that can be used for inducing an immune response to Borrelia burgdorferi in a subject by administering a therapeutically effective amount of the glycolipid to the subject. Such administration is particularly useful for preventing or treating Lyme disease in a subject. The compounds(s), and therapeutically acceptable salts thereof, may be formulated into pharmaceutical or immunogenic compositions.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: February 23, 2010
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Gil Ben-Menachem, Joanna Kubler-Kielb, Rachel Schneerson, John B. Robbins, Vince Pozsgay
  • Cholesterol-containing compounds and their use as immunogens against borrelia burgdorferi
    Publication number: 20060204515
    Abstract: Unique compounds that can be used for inducing an immune response to Borrelia burgdorferi in a subject by administering a therapeutically effective amount of the glycolipid to the subject. Such administration is particularly useful for preventing or treating Lyme disease in a subject. The compounds(s), and therapeutically acceptable salts thereof, may be formulated into pharmaceutical or immunogenic compositions.
    Type: Application
    Filed: April 2, 2004
    Publication date: September 14, 2006
    Inventors: Gil Ben-Menachem, Joanna Kubler-Kielb, Rachel Schneerson, John Robbins, Vince Pozsgay