Abstract: Technologies described in this document can be embodied in a computer-implemented method that includes receiving, via an interface displayed on a computing device, an identifier associated with a publication, and retrieving, by one or more processing devices based on the identifier, a set of attributes associated with the publication. The method also includes receiving, via the interface, one or more rule parameters representing a rule based on the publication, and receiving a set of health-related parameters representing a physical condition. The method further includes determining, based on at least a portion of the health-related parameters and the one or more rule parameters, whether the rule is applicable to the physical condition, and presenting a representation of the rule on an output device as a part of a list of rules in response to determining that the rule applies to the physical condition.

Abstract: This disclosure relates to technologies for evaluating health, wellness, and fitness parameters, and producing personalized recommendations, e.g., computer-implemented methods of receiving genetic information of a subject and information on a health-related parameter representing a health condition of the subject, and generating an output (e.g., a personalized recommendation) for the subject.

Abstract: The technology described in this document can be embodied in a computer-implemented method that includes accessing, by one or more processors, data for a plurality of health-related parameters of an individual, and determining, by the one or more processors, a corresponding individual age-adjustment factor based on data for one or more of the plurality of health-related parameters. The age-adjustment factor computed for a given health-related parameter represents an estimated gain or loss in age as indicated by the data for the given health-related parameter. The method also includes combining, by the one or more processors, two or more of the individual age-adjustment factors to provide a combined age-adjustment factor, and determining, by the one or more processors, a physiological age of the individual based on the combined age-adjustment factor and a chronological age of the individual.

Abstract: The technology described in this document can be embodied in a computer-implemented method for providing a dietary recommendation for an individual. The method includes accessing, by one or more processors, data for a plurality of health-related parameters of an individual, and identifying, by the one or more processors, a set of one or more out-of-range parameters from the plurality of health-related parameters. The method also includes identifying one or more food items from a database of food items, such that the identified food items are related to improving the corresponding levels of the one or more out-of-range parameters, and displaying the identified food items as the dietary recommendation on a user interface presented on a display device.

Abstract: Personalized, health and performance programs are generated for individuals based on various biomarkers and performance and lifestyle assessments. In one embodiment, a diagnostic test of blood or other biological specimen(s) is used to determine key biological marker levels. Information and assessments of the user's physical performance, life style and health and wellness goals is also collected and provided to an expert system that matches the biomarker levels and assessments to a knowledgebase of scientific knowledge about biomarker levels and health and fitness outcomes. Personal recommendations and advice on nutrition and exercise is then generated, which may be used to help individuals reach their diet, fitness, and wellness goals and improve their physical and mental performance and well being in measurable ways.

Abstract: Personalized, health and performance programs are generated for individuals based on various biomarkers and performance and lifestyle assessments. In one embodiment, a diagnostic test of blood or other biological specimen(s) is used to determine key biological marker levels. Information and assessments of the user's physical performance, life style and health and wellness goals is also collected and provided to an expert system that matches the biomarker levels and assessments to a knowledgebase of scientific knowledge about biomarker levels and health and fitness outcomes. Personal recommendations and advice on nutrition and exercise is then generated, which may be used to help individuals reach their diet, fitness, and wellness goals and improve their physical and mental performance and well being in measurable ways.

Abstract: Personalized, health and performance programs are generated for individuals based on various biomarkers and performance and lifestyle assessments. In one embodiment, a diagnostic test of blood or other biological specimen(s) is used to determine key biological marker levels. Information and assessments of the user's physical performance, life style and health and wellness goals is also collected and provided to an expert system that matches the biomarker levels and assessments to a knowledgebase of scientific knowledge about biomarker levels and health and fitness outcomes. Personal recommendations and advice on nutrition and exercise is then generated, which may be used to help individuals reach their diet, fitness, and wellness goals and improve their physical and mental performance and well being in measurable ways.

Abstract: Provided herein are methods and compositions relating to sirtuin modulation of Wnt pathway signaling, including the use of sirtuin and sirtuin-modulating agents in the prevention and treatment of cancer and other diseases.

Abstract: The present invention provides new and advantageous methods, compositions, cell constructs and animal models related to inhibiting the senescence of vertebrate cells and vertebrate organisms based on the use of SIRT1 polynucleotides and polypeptides, as well as mutant SIRT1 polynucleotides and polypeptides. The invention provides polynucleotides that encode variants and fragments of SIRT1 polypeptides, and also provides variant SIRT1 polypeptides and fragments thereof. Additionally the invention provides a method of inhibiting or delaying the expression in a vertebrate cell of a protein having biological activity associated with loss of population doubling in the cell. The invention further provides a method of treating a pathology, a disease or a medical condition in a subject, wherein the pathology responds to an SIRT1 polypeptide.