Patents by Inventor Gilad Barnea

Gilad Barnea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for labeling and manipulating a cellular circuit
    Patent number: 10619155
    Abstract: The invention relates to methods and kits for labeling and manipulating a cellular circuit. The methods includes transfecting a first-order cell in the cellular circuit with a nucleic acid molecule encoding a tethered ligand, and a second-order cell in the cellular circuit with a nucleic acid molecule encoding a receptor and an effector fusion polypeptide, a nucleic acid molecule encoding a receptor interactor and protease fusion polypeptide, and a nucleic acid molecule encoding a reporter/modifier gene.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: April 14, 2020
    Assignee: BROWN UNIVERSITY
    Inventors: Gilad Barnea, Mustafa Talay, Ethan Richman, John Szymanski, Mark Johnson, John Fisher, Nathaniel Snell
  • METHODS FOR LABELING AND MANIPULATING A CELLULAR CIRCUIT
    Publication number: 20180066249
    Abstract: The invention relates to methods and kits for labeling and manipulating a cellular circuit. The methods includes transfecting a first-order cell in the cellular circuit with a nucleic acid molecule encoding a tethered ligand, and a second-order cell in the cellular circuit with a nucleic acid molecule encoding a receptor and an effector fusion polypeptide, a nucleic acid molecule encoding a receptor interactor and protease fusion polypeptide, and a nucleic acid molecule encoding a reporter/modifier gene.
    Type: Application
    Filed: March 15, 2016
    Publication date: March 8, 2018
    Inventors: Gilad BARNEA, Mustafa TALAY, Ethan RICHMAN, John SZYMANSKI, Mark JOHNSON, John FISHER, Nathaniel SNELL
  • METHOD FOR ASSAYING PROTEIN-PROTEIN INTERACTION
    Publication number: 20120077706
    Abstract: The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
    Type: Application
    Filed: August 18, 2011
    Publication date: March 29, 2012
    Applicant: Life Technologies Corporation
    Inventors: Kevin J. LEE, Richard Axel, Walter Strapps, Gilad Barnea
  • Method for assaying protein-protein interaction
    Patent number: 8017398
    Abstract: The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: September 13, 2011
    Assignees: Life Technologies Corporation, The Trustees of Columbia University in the City of New York
    Inventors: Kevin J. Lee, Richard Axel, Walter Strapps, Gilad Barnea
  • Method for assaying protein-protein interaction
    Publication number: 20060147975
    Abstract: The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
    Type: Application
    Filed: February 2, 2006
    Publication date: July 6, 2006
    Inventors: Kevin Lee, Richard Axel, Walter Strapps, Gilad Barnea
  • Method for assaying protein—protein interaction
    Patent number: 7049076
    Abstract: The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: May 23, 2006
    Assignees: Sentigen Biosciences, Inc., The Trustees of Columbia University of the City of New York
    Inventors: Kevin J. Lee, Richard Axel, Walter Strapps, Gilad Barnea
  • Method for assaying protein-protein interaction
    Publication number: 20050100934
    Abstract: The invention relates to a method for determining if a test compound, or a mix of compounds, modulates the interaction between two proteins of interest. The determination is made possible via the use of two recombinant molecules, one of which contains the first protein a cleavage site for a proteolytic molecules, and an activator of a gene. The second recombinant molecule includes the second protein and the proteolytic molecule. If the test compound binds to the first protein, a reaction is initiated whereby the activator is cleaved, and activates a reporter gene.
    Type: Application
    Filed: July 9, 2004
    Publication date: May 12, 2005
    Inventors: Kevin Lee, Richard Axel, Walter Strapps, Gilad Barnea
  • RPTP-&bgr; antibodies
    Patent number: 6803452
    Abstract: A new class of receptor protein tyrosine phosphatase molecule, the families of ligands that binds this new class of receptor, and uses of such receptors and ligands is described.
    Type: Grant
    Filed: December 4, 2001
    Date of Patent: October 12, 2004
    Assignee: New York University
    Inventors: Joseph Schlessinger, Gilad Barnea
  • Class of RPTPases: their structural domains and ligands
    Publication number: 20020127226
    Abstract: A new class of receptor protein tyrosine phosphatase molecule, the families of ligands that binds this new class of receptor, and uses of such receptors and ligands is described.
    Type: Application
    Filed: December 4, 2001
    Publication date: September 12, 2002
    Inventors: Joseph Schlessinger, Gilad Barnea, Martin Hyman Grumet, Richard U. Margolis
  • Receptor protein tyrosine phosphatases
    Patent number: 6160090
    Abstract: A novel receptor-type protein tyrosine phosphatase-.beta. (RPTP.beta.) protein or glycoprotein is disclosed. This protein is naturally expressed in the brain and in neural cell lines.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: December 12, 2000
    Assignee: New York University
    Inventors: Joseph Schlessinger, Gilad Barnea, Martin Hyman Grumet, Richard U. Margolis