Patents by Inventor Gilbert M. Iverson

Gilbert M. Iverson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition for inducing humoral anergy to an immunogen comprising a T cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic valency platform molecule
    Patent number: 7138244
    Abstract: Conjugates of nonimmunogenic valency platform molecules and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: November 21, 2006
    Assignee: La Jolla Pharmaceutical Company
    Inventors: Paul A. Barstad, Gilbert M. Iverson
  • Therapeutic and diagnostic domain 1 ?2GPI polypeptides and methods of using same
    Patent number: 6858210
    Abstract: The present invention provides domain 1 ?2GPI polypeptides, polynucleotides encoding these polypeptides, mimetics of these polypeptides, and methods using domain 1 ?2GPI polypeptides and mimetics. Domain 1 of ?2GPI has been shown to bind to anti-cardiolipin (?2GPI-dependent antiphospholipid) antibodies, which are associated with several pathologies, such as thrombosis and fetal loss. The domain 1 ?2GPI polypeptides may be used to detect ?2GPI-dependent antiphospholipid antibodies in a sample. The invention further provides methods of inducing tolerance using these domain 1 ?2GPI polypeptides.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: February 22, 2005
    Assignee: La Jolla Pharmaceutical Co.
    Inventors: David M. Marquis, Gilbert M. Iverson, Edward J. Victoria, David S. Jones, Matthew D. Linnik
  • Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
    Patent number: 5268454
    Abstract: Conjugates of stable nonimmunogenic polymers and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.
    Type: Grant
    Filed: February 8, 1991
    Date of Patent: December 7, 1993
    Assignee: La Jolla Pharmaceutical Company
    Inventors: Paul A. Barstad, Gilbert M. Iverson