Abstract: A means and method for treating inflamed mucosal tissues topically with a non-steroidal anti-inflammatory drug (NSAID) is described. The NSAID is incorporated into a substantive film forming aqueous based carrier system consisting of a water dispersible natural cellulosic polymer and an organic acid. The NSAID composition may further include a water soluble or water hydratable viscosity enhancing agent and/or a plasticizer. The NSAID topical composition is especially effective in treating pain associated with vulvodynia or vulvar vestibulitis.

Abstract: A method for making an oxidized cellulose product from a cellulose material is disclosed. The method involves oxidizing a cellulose material into an oxidized cellulose product, comprising treating the cellulose material with a hypochlorite solution having an active chlorine content of between about 4 and about 6%, at a pH exceeding 9.5 and at a temperature, and for a time, effective to convert the cellulose material into the oxidized cell product; filtering the oxidized cellulose product; and washing the oxidized cell product with an antichlor agent such as sodium thiosulfate to remove chlorine and to raise the oxidized cellulose product to a neutral pH.The oxidized cellulose product may be used to form films, dispersions, gels, as carriers, for pharmaceuticals, cosmetics and other products.

Abstract: A rapid method to prepare low crystallinity cellulose (crystallinity 15-45% of polymerization 35-150), suitable for use as a direct compression excipient (e.g., binder, disintegrant, and diluent) in pharmaceutical solid dosage forms design and as a bodying and/or film forming agent in the development of sustained- and/or film forming agent in the development of sustained- and/or controlled-release pharmaceutical (topical and transdermal products), cosmetics, agricultural, personal care and like products, is provided by reacting cellulose materials with 85% or higher weight percentage phosphoric acid under controlled sequenced temperature conditions that involve treatment first at room temperature for an hour and then at 50.degree.-55.degree. C. for 3-6 hours, followed by separating by a precipitation method,. and subsequently isolating as a powder or converting into a head or hydrated form.

Abstract: Microfibrillated oxycellulose suitable for use as a carrier in agricultural, cosmetic, and topical and transdermal drug products, and as a binder and disintegrant in the making of tablets, is prepared by the oxidation of cellulosic materials with persulfate salts in water, with or without the presence of an aqueous inorganic acid, or in glacial or aqueous acetic acid.

Abstract: A rapid method to prepare low crystallinity cellulose (crystallinity 15-45% of polymerization 35-150), suitable for use as a direct compression excipient (e.g., binder, disintegrant, and diluent) in pharmaceutical solid dosage forms design and as a bodying and/or film forming agent in the development of sustained- and/or film forming agent in the development of sustained- and/or controlled-release pharmaceutical (topical and transdermal products), cosmetics, agricultural, personal care and like products, is provided by reacting cellulose materials with 85% or higher weight percentage phosphoric acid under controlled sequenced temperature conditions that involve treatment first at room temperature for an hour and then at 50.degree.-55.degree. C./ for 3-6 hours, followed by separating by a precipitation method,. and subsequently isolating as a powder or converting into a head or hydrated form.

Abstract: A method for making an oxidized cellulose product from a cellulose material is disclosed. The method involves oxidizing a cellulose material into an oxidized cellulose product, comprising treating the cellulose material with a hypochlorite solution having an active chlorine content of between about 4 and about 6%, at a pH exceeding 9.5 and at a temperature, and for a time, effective to convert the cellulose material into the oxidized cellulose product; filtering the oxidized cellulose product; and washing the oxidized cellulose product with an antichlor agent such as sodium thiosulfate to remove chlorine and to raise the oxidized cellulose product to a neutral pH.The oxidized cellulose product may be used to form films, dispersions, gels, as carriers, for pharmaceuticals, cosmetics and other products.

Abstract: Microfibrillated oxycellulose suitable for use as a carrier in agricultural, cosmetic, and topical and transdermal drug products, and as a binder and disintegrant in the making of tablets, is prepared by the oxidation of cellulosic materials with persulfate salts in water, with or without the presence of an aqueous inorganic acid, or in glacial or aqueous acetic acid.

Abstract: Pharmaceutical coatings in the form of aqueous dispersion of a water insoluble polymer prepared by dissolving the polymer in a water immiscible organic solvent, emulsifying the organic solution in water, optionally with the aid of additives, and stripping the organic solvent from the system to provide a colloidal, or near colloidal, aqueous dispersion or latex of small, even sized polymeric particles which are applied to pharmaceutical dosages from highly loaded latices. The latexes, which display resistance to bacterial and mold growth and, when combined with selected additives, provides convenient, attractive coating compositions which afford excellent protection and varied release properties to pharmaceutical dosages.