Patents by Inventor Gilbert Vassart
Gilbert Vassart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9040670Abstract: Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab?)2, Fab or Fv) or humanized forms of such monoclonal antibodies or single chain forms (SCA; scFv) of such fragments, which antibodies, or their fragments, compete with bovine TSH for epitopes of the human TSHr, compete with autoantibodies from sera from Graves' patients as well as with autoantibodies from sera from patients harboring blocking autoantibodies for epitopes of the human TSHr, bind to conformational epitopes of the human TSHr located in the first 281 amino acids of the human TSHr, and usually also bind to TSFR receptors (TSHr) from different animals. Various uses of such antibodies, or of peptides corresponding to variable regions of such antibodies, are also described and claimed.Type: GrantFiled: July 12, 2011Date of Patent: May 26, 2015Assignee: B.R.A.H.M.S GMBHInventors: Andreas Bergmann, Nils G. Morgenthaler, Gilbert Vassart, Sabine Costagliola
-
Patent number: 8501415Abstract: The present invention relates to the use of affinity-purified polyclonal human autoantibodies against the TSH receptor (TSHR-Auto-Ab), obtained from the serum of Graves' disease patients and which have been purified to obtain biochemical homogeneity and comprise a specific activity of at least 1 IU/mg protein (human immunoglobulin). Also disclosed is the use of animal antibodies, which compete with the former for the binding sites of a functional human TSH receptor, as a specific binding reagent in an immunological determination method for the clinical identification of autoantibodies against the TSH receptor (TSHR-Auto-Ab) in a sample of a biological fluid of a patient to be examined for Graves' disease.Type: GrantFiled: October 31, 2003Date of Patent: August 6, 2013Assignee: B.R.A.H.M.S. GmbHInventors: Andreas Bergmann, Sabine Costagliola, Gilbert Vassart
-
Publication number: 20120253019Abstract: Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab?)2, Fab or Fv) or humanized forms of such monoclonal antibodies or single chain forms (SCA; scFv) of such fragments, which antibodies, or their fragments, compete with bovine TSH for epitopes of the human TSHr, compete with autoantibodies from sera from Graves' patients as well as with autoantibodies from sera from patients harboring blocking autoantibodies for epitopes of the human TSHr, bind to conformational epitopes of the human TSHr located in the first 281 amino acids of the human TSHr, and usually also bind to TSFR receptors (TSHr) from different animals. Various uses of such antibodies, or of peptides corresponding to variable regions of such antibodies, are also described and claimed.Type: ApplicationFiled: July 12, 2011Publication date: October 4, 2012Applicant: B.R.A.H.M.S GMBHInventors: Andreas BERGMANN, Nils G. MORGENTHALER, Gilbert VASSART, Sabine COSTAGLIOLA
-
Patent number: 8030453Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: GrantFiled: February 19, 2009Date of Patent: October 4, 2011Assignee: Euroscreen S.A.Inventors: Valerie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
-
Patent number: 8029790Abstract: Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab?)2, Fab or Fv) or humanized forms of such monoclonal antibodies or single chain forms (SCA; scFv) of such fragments, which antibodies, or their fragments, compete with bovine TSH for epitopes of the human TSHr, compete with autoantibodies from sera from Graves' patients as well as with autoantibodies from sera from patients harboring blocking autoantibodies for epitopes of the human TSHr, bind to conformational epitopes of the human TSHr located in the first 281 amino acids of the human TSHr, and usually also bind to TSFR receptors (TSHr) from different animals. Various uses of such antibodies, or of peptides corresponding to variable regions of such antibodies, are also described and claimed.Type: GrantFiled: June 16, 2005Date of Patent: October 4, 2011Assignee: B.R.A.H.M.S. GmbHInventors: Andreas Bergmann, Nils G. Morgenthaler, Gilbert Vassart, Sabine Costagliola
-
Patent number: 8003347Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: GrantFiled: August 1, 2008Date of Patent: August 23, 2011Assignee: Euroscreen S.A.Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul
-
Publication number: 20110033467Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: ApplicationFiled: February 19, 2009Publication date: February 10, 2011Inventors: Valerie Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
-
Patent number: 7858755Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: GrantFiled: July 16, 2004Date of Patent: December 28, 2010Assignee: Euroscreen S.A.Inventors: Valerie Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel LePoul, Cecile Loison, Frédéric Ooms
-
Patent number: 7842453Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: GrantFiled: October 26, 2007Date of Patent: November 30, 2010Assignee: Euroscreen S.A.Inventors: Valeria Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul
-
Publication number: 20100267138Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: ApplicationFiled: February 19, 2009Publication date: October 21, 2010Inventors: Valerie Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
-
Patent number: 7666401Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: GrantFiled: October 30, 2007Date of Patent: February 23, 2010Assignee: Euroscreen S.A.Inventors: Valeria Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul, Cecile Loison, Frederic Ooms
-
Publication number: 20100009345Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: ApplicationFiled: October 26, 2007Publication date: January 14, 2010Inventors: Valeria Wittamer, J.F. Mirjolet, Isabelle Migeotte, Daivd Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
-
Patent number: 7582734Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: GrantFiled: September 29, 2006Date of Patent: September 1, 2009Assignee: Euroscreen S.A.Inventors: Valeria Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul, Cecile Loison, Frederic Ooms
-
Publication number: 20090081729Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: ApplicationFiled: August 1, 2008Publication date: March 26, 2009Applicant: Euroscreen S.A.Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
-
Publication number: 20090047741Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: ApplicationFiled: October 30, 2007Publication date: February 19, 2009Inventors: Valeria Wittamer, J.F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
-
Publication number: 20090012268Abstract: Monoclonal antibodies (mAbs) having thyroid stimulating activity (TSAb), especially full or considerably agonistic activity, or thyroid blocking activity (TBAb), which are obtainable by genetic immunization of mice, or fragments (F(ab?)2, Fab or Fv) or humanized forms of such monoclonal antibodies or single chain forms (SCA; scFv) of such fragments, which antibodies, or their fragments, compete with bovine TSH for epitopes of the human TSHr, compete with autoantibodies from sera from Graves' patients as well as with autoantibodies from sera from patients harboring blocking autoantibodies for epitopes of the human TSHr, bind to conformational epitopes of the human TSHr located in the first 281 amino acids of the human TSHr, and usually also bind to TSFR receptors (TSHr) from different animals. Various uses of such antibodies, or of peptides corresponding to variable regions of such antibodies, are also described and claimed.Type: ApplicationFiled: June 16, 2005Publication date: January 8, 2009Applicant: B.R.A.H.M.S AKTIENGESELLSCHAFTInventors: Andreas Bergmann, Nils G. Morgenthaler, Gilbert Vassart, Sabine Costagliola
-
Patent number: 7470772Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: GrantFiled: September 29, 2006Date of Patent: December 30, 2008Assignee: Euroscreen s.a.Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
-
Patent number: 7419658Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: GrantFiled: June 25, 2003Date of Patent: September 2, 2008Assignee: Euroscreen s.a.Inventors: Valerie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
-
Publication number: 20080125357Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: ApplicationFiled: March 13, 2006Publication date: May 29, 2008Inventors: Valerie Wittamer, J.F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
-
Patent number: 7332291Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.Type: GrantFiled: May 20, 2005Date of Patent: February 19, 2008Assignee: Euroscreen s.a.Inventors: Valérie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stéphane Brézillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul