Abstract: The present invention relates to a process for preparing hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hepten-1-yl]-3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula (I). In accordance with the present invention, the compound (I) can be efficiently prepared with high purity by coupling bimatoprost in a boronate protected form with 6-(nitrooxy)hexanoyl chloride and removing the boronate protecting group. The invention also relates to a process for the preparation of 6-(nitrooxy) hexanoic acid having a HPLC purity equal to or greater than 99% and containing an amount of 6-{[6-(nitrooxy)hexanoyl]oxy}hexanoic acid (compound (IXa) equal to or lower than 0.2%.

Abstract: The present invention relates to an in silico method for predicting the ability of an antibody to recognize the epitope of another antibody, based on a measure of similarity of antibody sequence and structure.

Abstract: A padded and recyclable paper envelope is comprised of a front wall, a rear wall, an open edge for access to an interior compartment of the envelope, and a closure flap to close the open edge. A corrugated board is adhesively secured over an inner face of the front wall and rear wall to protect an item disposed in the interior compartment between the reinforcing corrugated board surfaces. The envelope is formed from a single paper blank on which the corrugated board is adhesively secured. The envelope and the corrugated board are formed from recyclable material.