Patents by Inventor Gillian Marguerite Beattie

Gillian Marguerite Beattie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and method of stimulating the proliferation and differentiation of human fetal and adult pancreatic cells ex vivo
    Patent number: 5888705
    Abstract: A method of inducing the proliferation and/or differentiation of human adult pancreatic cells entails contacting primary cultures of such cells with Hepatocyte Growth Factor/Scatter Factor (HGF/SF), thereby inducing a proliferation of .beta.-epithelial cells, an increase in the number of .beta.-epithelial cells which form islet-like cell clusters, and an increase in insulin production per cell. The method is improved by culturing the cells on an extracellular matrix such as 804G in the presence of HGF/SF, and is further improved by reaggregating thus-treated cells and contacting said cells with an insulin gene upregulating agent such as a poly(ADP-ribose) synthetase inhibitor such as a nicotinamide or benzamide. The method provides increased numbers of functional islet-like cell clusters for transplantation.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: March 30, 1999
    Assignees: The United States of America as represented by the Department of Health and Human Services, The Whittier Institute for Diabetes and Endocrinology
    Inventors: Jeffrey Rubin, Alberto Hayek, Gillian Marguerite Beattie, Timo Pyry Juhani Otonkoski, Vito Quaranta