Patents by Inventor Giman Jung
Giman Jung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11733250Abstract: The purpose of the present invention is to provide a simple and highly accurate method for detecting pancreatic exocrine dysfunction with minimal invasiveness to a subject. The method comprising in vitro measurement of two APOA2 protein variants, mutants thereof and/or fragments thereof in a body fluid sample derived from the subject and detection of the presence or absence of pancreatic exocrine dysfunction on the basis of the measured amounts, and a detection kit for pancreatic exocrine dysfunction including antibodies that can specifically bind to said proteins are provided.Type: GrantFiled: September 28, 2021Date of Patent: August 22, 2023Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTERInventors: Michimoto Kobayashi, Mitsuaki Sanada, Yoshiyuki Sasajima, Giman Jung, Tesshi Yamada, Kazufumi Honda
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Publication number: 20220120752Abstract: The present invention provides a method for detecting biliary tract cancer by measuring the amounts of APOA2 protein variants in a test sample with anti-APOA2 antibodies, the anti-APOA2 antibodies for use in the above method and a detection kit for biliary tract cancer including the above antibodies.Type: ApplicationFiled: December 28, 2021Publication date: April 21, 2022Applicants: Toray Industries, Inc., NATIONAL CANCER CENTERInventors: Mitsuaki Sanada, Michimoto Kobayashi, Aiko Takayama, Yoshiyuki Sasajima, Giman Jung, Tesshi Yamada, Kazufumi Honda
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Patent number: 11231423Abstract: The present invention provides a method for detecting biliary tract cancer by measuring the amounts of APOA2 protein variants in a test sample with anti-APOA2 antibodies, the anti-APOA2 antibodies for use in the above method and a detection kit for biliary tract cancer including the above antibodies.Type: GrantFiled: January 25, 2016Date of Patent: January 25, 2022Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTERInventors: Mitsuaki Sanada, Michimoto Kobayashi, Aiko Takayama, Yoshiyuki Sasajima, Giman Jung, Tesshi Yamada, Kazufumi Honda
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Publication number: 20220011322Abstract: The purpose of the present invention is to provide a simple and highly accurate method for detecting pancreatic exocrine dysfunction with minimal invasiveness to a subject. The method comprising in vitro measurement of two APOA2 protein variants, mutants thereof and/or fragments thereof in a body fluid sample derived from the subject and detection of the presence or absence of pancreatic exocrine dysfunction on the basis of the measured amounts, and a detection kit for pancreatic exocrine dysfunction including antibodies that can specifically bind to said proteins are provided.Type: ApplicationFiled: September 28, 2021Publication date: January 13, 2022Applicants: Toray Industries, Inc., NATIONAL CANCER CENTERInventors: Michimoto Kobayashi, Mitsuaki Sanada, Yoshiyuki Sasajima, Giman Jung, Tesshi Yamada, Kazufumi Honda
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Patent number: 11162956Abstract: The purpose of the present invention is to provide a simple and highly accurate method for detecting pancreatic exocrine dysfunction with minimal invasiveness to a subject. The method comprising in vitro measurement of two APOA2 protein variants, mutants thereof and/or fragments thereof in a body fluid sample derived from the subject and detection of the presence or absence of pancreatic exocrine dysfunction on the basis of the measured amounts, and a detection kit for pancreatic exocrine dysfunction including antibodies that can specifically bind to said proteins are provided.Type: GrantFiled: March 1, 2016Date of Patent: November 2, 2021Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTERInventors: Michimoto Kobayashi, Mitsuaki Sanada, Yoshiyuki Sasajima, Giman Jung, Tesshi Yamada, Kazufumi Honda
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Publication number: 20180031574Abstract: The purpose of the present invention is to provide a simple and highly accurate method for detecting pancreatic exocrine dysfunction with minimal invasiveness to a subject. The method comprising in vitro measurement of two APOA2 protein variants, mutants thereof and/or fragments thereof in a body fluid sample derived from the subject and detection of the presence or absence of pancreatic exocrine dysfunction on the basis of the measured amounts, and a detection kit for pancreatic exocrine dysfunction including antibodies that can specifically bind to said proteins are provided.Type: ApplicationFiled: March 1, 2016Publication date: February 1, 2018Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTERInventors: Michimoto Kobayashi, Mitsuaki Sanada, Yoshiyuki Sasajima, Giman Jung, Tesshi Yamada, Kazufumi Honda
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Publication number: 20180017564Abstract: The present invention provides a method for detecting biliary tract cancer by measuring the amounts of APOA2 protein variants in a test sample with anti-APOA2 antibodies, the anti-APOA2 antibodies for use in the above method and a detection kit for biliary tract cancer including the above antibodies.Type: ApplicationFiled: January 25, 2016Publication date: January 18, 2018Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTERInventors: Mitsuaki Sanada, Michimoto Kobayashi, Aiko Takayama, Yoshiyuki Sasajima, Giman Jung, Tesshi Yamada, Kazufumi Honda
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Publication number: 20160245815Abstract: It is intended to provide a method for detecting a pancreatic tumor (pancreatic cancer or benign pancreatic tumor) with low invasiveness to a test subject and with high detection sensitivity and accuracy. The present invention provides a method for detecting a pancreatic tumor by measuring the amounts of APOA2 protein variants in a sample of a test subject using anti-APOA2 antibodies, anti-APOA2 antibodies for use in the method, and a kit for the detection of a pancreatic tumor, comprising the antibodies.Type: ApplicationFiled: September 30, 2014Publication date: August 25, 2016Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTERInventors: Mitsuaki SANADA, Michimoto KOBAYASHI, Aiko TAKAYAMA, Yoshiyuki SASAJIMA, Giman JUNG, Tesshi YAMADA, Kazufumi HONDA
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Patent number: 9309312Abstract: An object of the present invention is to detect a human CXCL1 protein with high sensitivity. An immunoassay method is provided for a human CXCL1 protein, by which human CXCL1 or a fragment thereof in a sample is measured using two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof, wherein: each of the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognizes any one of sequence regions of the amino acid sequences shown in SEQ ID NOS: 1-3, which are partial sequences of the amino acid sequence composing a human CXCL1 protein; and the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognize sequence regions that differ from each other. Monoclonal antibodies or fragments thereof are provided, each of which specifically recognizes any one sequence region of the amino acid sequences shown in SEQ ID NOS: 1-3 and has a new amino acid sequence.Type: GrantFiled: October 29, 2009Date of Patent: April 12, 2016Assignee: TORAY INDUSTRIES, INC.Inventors: Satoko Kanamori, Giman Jung, Yoshinori Tanaka, Aiko Takayama
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Patent number: 9127054Abstract: An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.Type: GrantFiled: December 5, 2011Date of Patent: September 8, 2015Assignees: TORAY INDUSTRIES, INC., KYOTO UNIVERSITYInventors: Michimoto Kobayashi, Yoshinori Tanaka, Aiko Takayama, Satoko Kanamori, Giman Jung, Yoshiharu Sakai, Hiroshi Okabe
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Patent number: 9081013Abstract: It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.Type: GrantFiled: March 3, 2011Date of Patent: July 14, 2015Assignees: TORAY INDUSTRIES, INC., KYOTO UNIVERSITYInventors: Yoshinori Tanaka, Satoko Kanamori, Michimoto Kobayashi, Giman Jung, Yoshiharu Sakai, Hiroshi Okabe
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Publication number: 20140363825Abstract: This invention relates to a method for detecting or examining a cancer selected from colorectal cancer and esophageal cancer with high detection sensitivity and accuracy and with less invasiveness to a subject. Specifically, it relates to a method for examining a cancer comprising measuring in vitro a COTL1 protein in a body fluid sample from a subject and evaluating whether or not the subject suffers from the cancer based on the measured amount of the COTL1 protein. It further relates to a kit for diagnosis of a cancer selected from colorectal cancer and esophageal cancer comprising an antibody or a fragment thereof capable of specifically binding to the protein.Type: ApplicationFiled: August 28, 2012Publication date: December 11, 2014Applicants: KYOTO UNIVERSITY, TORAY INDUSTRIES, INC.Inventors: Michimoto Kobayashi, Yoshinori Tanaka, Aiko Takayama, Giman Jung, Yoshiharu Sakai, Hiroshi Okabe
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Publication number: 20130288277Abstract: An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.Type: ApplicationFiled: December 5, 2011Publication date: October 31, 2013Applicants: KYOTO UNIVERSITY, TORAY INDUSTRIES, INC.Inventors: Michimoto Kobayashi, Yoshinori Tanaka, Aiko Takayama, Satoko Kanamori, Giman Jung, Yoshiharu Sakai, Hiroshi Okabe
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Publication number: 20130011865Abstract: It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of Cofilin 1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.Type: ApplicationFiled: March 3, 2011Publication date: January 10, 2013Inventors: Michimoto Kobayashi, Yoshinori Tanaka, Satoko Kanamori, Giman Jung, Yoshiharu Sakai, Hiroshi Okabe
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Publication number: 20120329074Abstract: It is intended to provide a method for detecting gastric cancer, which is low invasive to a human test subject and has high detection sensitivity and accuracy. The present invention provides a method comprising measuring in vitro the amount of COTL1 protein, a variant thereof, and/or a fragment thereof in a body fluid sample derived from a human test subject, and detecting the presence or absence of gastric cancer affecting the test subject on the basis of the amount, and a kit for gastric cancer diagnosis comprising an antibody capable of specifically binding to the protein.Type: ApplicationFiled: March 3, 2011Publication date: December 27, 2012Inventors: Yoshinori Tanaka, Satoko Kanamori, Michimoto Kobayashi, Giman Jung, Yoshiharu Sakai, Hiroshi Okabe
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Publication number: 20110287444Abstract: An object of the present invention is to detect a human CXCL1 protein with high sensitivity. An immunoassay method is provided for a human CXCL1 protein, by which human CXCL1 or a fragment thereof in a sample is measured using two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof, wherein: each of the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognizes any one of sequence regions of the amino acid sequences shown in SEQ ID NOS: 1-3, which are partial sequences of the amino acid sequence composing a human CXCL1 protein; and the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognize sequence regions that differ from each other. Monoclonal antibodies or fragments thereof are provided, each of which specifically recognizes any one sequence region of the amino acid sequences shown in SEQ ID NOS: 1-3 and has a new amino acid sequence.Type: ApplicationFiled: October 29, 2009Publication date: November 24, 2011Applicant: TORAY INDUSTRIES, INC.Inventors: Satoko Kanamori, Giman Jung, Yoshinori Tanaka, Aiko Takayama
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Publication number: 20110045495Abstract: The present invention relates to a method for detection of a renal cancer, comprising measuring any one of or a plurality of polypeptides shown in SEQ ID NOS: 1-7, mutants thereof, or fragments thereof in a biological sample from a subject, and to a composition for diagnosis or detection of the renal cancer.Type: ApplicationFiled: January 16, 2009Publication date: February 24, 2011Inventors: Yoshinori Tanaka, Michimoto Kobayashi, Shiori Tomoda, Giman Jung, Osamu Ogawa, Eijiro Nakamura
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Patent number: 7795010Abstract: The following is disclosed: (1) a membrane fractionator including a filtration section, a concentrating section, a recovery section and a liquid feed pump, wherein a flow channel connecting the filtration section, concentrating section and recovery section to each other constitutes a closed circuitry; (2) a method of biocomponent separation, characterized in that a sample derived from biocomponents is fed into an antibody adsorption membrane separation system having an antibody capable of adsorbing specified protein internally accommodated in the middle or a rear part of a membrane separation system that in the absence of antibodies adsorbing proteins, exhibits a permeation ratio between human alpha1-microglobulin and human albumin of 1.Type: GrantFiled: January 20, 2005Date of Patent: September 14, 2010Assignee: Toray Industries, Inc.Inventors: Kazuhiro Tanahashi, Ichiro Kumo, Nobuyuki Kuroki, Hiroyuki Sugaya, Satoko Yamada, Shigehisa Wada, Giman Jung, Toshihiko Kuroda, Shuji Sekiguchi
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Publication number: 20100152055Abstract: This invention relates to a composition, kit, DNA chip, and use thereof for detecting, diagnosing, and predicting metastasis of kidney cancer and/or for predicting the prognosis for kidney cancer, comprising one or a plurality of polynucleotides selected from the group consisting of polynucleotides, mutants thereof or fragments thereof, the expression levels of which vary in kidney cancer cells from a patient with a poor prognosis when compared with that in kidney cancer cells from a patient with a good prognosis; or antibodies or fragments thereof that bind specifically to polypeptides, mutants thereof or fragments thereof, the expression levels of which vary in the similar manner.Type: ApplicationFiled: September 1, 2006Publication date: June 17, 2010Inventors: Satoko Kozono, Hideo Akiyama, Akira Myomoto, Yoshinori Tanaka, Giman Jung, Hitoshi Nobumasa, Osamu Nomura, Osamu Ogawa, Eijiro Nakamura, Gozo Tsujimoto
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Publication number: 20090297733Abstract: A lab-on-chip substrate includes a resin having a silicon content of 10% or less by weight as its base material and a hydrophilic polymer covalently bound onto the surface thereof by high-energy ray irradiation suitable for a protein-processing chip. The lab-on-chip substrate is resistant to washing and usable for an extended period of time without adsorption of proteins on the base material surface, i.e., a protein electrophoretic polymeric chip having a microchannel allowing high-accuracy analysis of trace amounts of proteins because of reduction in the amount of detection noise.Type: ApplicationFiled: August 13, 2009Publication date: December 3, 2009Applicant: Toray Industries, Inc.Inventors: Yoshiaki Yamazaki, Naoki Kawazoe, Masashi Higasa, Giman Jung, Hitoshi Nobumasa, Yuji Murakami