Patents by Inventor Gin-Chung Liu

Gin-Chung Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ligand and metal complex having the same
    Patent number: 8961928
    Abstract: A ligand and a metal complex having the ligand are provided. The ligand and a paramagnetic metal ion form a metal complex with high stability, high relaxivity and high biocompatibility. The metal complex of the present invention is applicable to the preparation of MRI contrast agents for detecting atherosclerosis. The MRI contrast agent includes a peptide sequence specific to a matrix metalloprotease, and can be recognized by a pathological thrombocyte to target a specific site, so as to enhance the imaging contrast.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: February 24, 2015
    Assignee: National Chiao Tung University
    Inventors: Yun-Ming Wang, Gin-Chung Liu, Chiao-Yun Chen, Teng-Wen Li
  • Cycloalkyl triamine pentacarboxylate as ligands for paramagnetic metal complexes
    Patent number: 8877163
    Abstract: A cycloalkyl triamine pentacarboxylate compound coordinating to a metal ion to form a high stability metal complex in serum is provided. The metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).
    Type: Grant
    Filed: September 21, 2006
    Date of Patent: November 4, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Yun-Ming Wang, Chih-Wei Chiu, Gin-Chung Liu
  • LIGAND AND METAL COMPLEX HAVING THE SAME
    Publication number: 20130303728
    Abstract: A ligand and a metal complex having the ligand are provided. The ligand and a paramagnetic metal ion form a metal complex with high stability, high relaxivity and high biocompatibility. The metal complex of the present invention is applicable to the preparation of MRI contrast agents for detecting atherosclerosis. The MRI contrast agent includes a peptide sequence specific to a matrix metalloprotease, and can be recognized by a pathological thrombocyte to target a specific site, so as to enhance the imaging contrast.
    Type: Application
    Filed: May 9, 2012
    Publication date: November 14, 2013
    Applicant: NATIONAL CHIAO TUNG UNIVERSITY
    Inventors: Yun-Ming Wang, Gin-Chung Liu, Chiao-Yun Chen, Teng-Wen Li
  • Folate-receptor-targeting iron oxide nanoparticles coated with poly(ethylene glycol)
    Patent number: 7598335
    Abstract: The present invention provides the synthetic method and superparamagnetic iron oxide nanoparticles capable of targeting to the folic acid receptors existing on the cell membranes and with high relaxivity. The iron oxide nanoparticles of the present invention can further be used as the contrast agents for magnetic resonance imaging (MRI).
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: October 6, 2009
    Assignee: Kaohsiung Medical University
    Inventors: Yun-Ming Wang, Kuei-Tang Lin, Ting-Jung Chen, Gin-Chung Liu
  • Prostate-specific antigen probes for optical imaging
    Patent number: 7371728
    Abstract: This invention provides a novel probe, which contains a prostate peptide substrate. The probe can be used as a prostate diagnostic agent for optical imaging. An 11 amino acid peptide substrate is synthesized for specific prostate-specific antigen (PSA). This protected graft copolymer (PGC) consists of a poly-L-lysine (PL) backbone and methoxypoly(ethylene glycol) (MPEG). Two terminals of peptide substrate are bound to poly-L-lysine and Cy5.5 fluorochrome. This probe will be used as a NIR (near-infrared fluorescence) probe for optical imaging.
    Type: Grant
    Filed: January 4, 2006
    Date of Patent: May 13, 2008
    Assignee: Kaohsiung Medical University
    Inventors: Yun-Ming Wang, Wei-Hsan Chao, Gin-Chung Liu, Jui-Sheng Hsu
  • FOLATE-RECEPTOR-TARGETING IRON OXIDE NANOPARTICLES COATED WITH POLY(ETHYLENE GLYCOL)
    Publication number: 20080081891
    Abstract: The present invention provides the synthetic method and superparamagnetic iron oxide nanoparticles capable of targeting to the folic acid receptors existing on the cell membranes and with high relaxivity. The iron oxide nanoparticles of the present invention can further be used as the contrast agents for magnetic resonance imaging (MRI).
    Type: Application
    Filed: June 29, 2007
    Publication date: April 3, 2008
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Yun-Ming Wang, Kuei-Tang Lin, Ting-Jung Chen, Gin-Chung Liu
  • Cycloalkyl triamine pentacarboxylate as ligands for paramagnetic metal complexes
    Publication number: 20070207087
    Abstract: A cycloalkyl triamine pentacarboxylate compound coordinating to a metal ion to form a high stability metal complex in serum is provided. The metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).
    Type: Application
    Filed: September 21, 2006
    Publication date: September 6, 2007
    Applicant: Kaohsiung Medical University
    Inventors: Yun-Ming Wang, Chih-Wei Chiu, Gin-Chung Liu
  • Prostate-specific antigen probes for optical imaging
    Publication number: 20060154324
    Abstract: This invention provides a novel probe, which contains a prostate peptide substrate. The probe can be used as a prostate diagnostic agent for optical imaging. An 11 amino acid peptide substrate is synthesized for specific prostate-specific antigen (PSA). This protected graft copolymer (PGC) consists of a poly-L-lysine (PL) backbone and methoxypoly(ethylene glycol) (MPEG). Two terminals of peptide substrate are bound to poly-L-lysine and Cy5.5 fluorochrome. This probe will be used as a NIR (near-infrared fluorescence) probe for optical imaging.
    Type: Application
    Filed: January 4, 2006
    Publication date: July 13, 2006
    Applicant: Kaohsiung Medical University
    Inventors: Yun-Ming Wang, Wei-Hsan Chao, Gin-Chung Liu, Jui-Sheng Hsu
  • Galactopyrannosyltriaminetetracarboxylate as ligands for bioactivated paramagnetic metal complexes
    Publication number: 20060034774
    Abstract: The present invention provides a triaminetetraacetatesaccharide coordinating to metal ion to form bioactive metal complexes. The bioactive metal complexes of the present invention can be used as contrast agents for magnetic resonance imaging (MRI).
    Type: Application
    Filed: August 10, 2005
    Publication date: February 16, 2006
    Inventors: Yun-Ming Wang, Ya-Wen Hsu, Gin-Chung Liu
  • Triaminepentaacetic acid compound and paramagnetic metal complex prepared from using the compound as ligand
    Patent number: 6303761
    Abstract: The present invention provides a triaminepentaacetic acid compound which can be used as a ligand to coordinate to a metal ion to form a paramagnetic metal complex. The paramagnetic metal complex of the present invention can be used as a contrast agent for magnetic resonance imaging (MRI).
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: October 16, 2001
    Assignee: Department of Health The Executive Yuan, Republic of China
    Inventors: Yun-Ming Wang, Gin-Chung Liu, Chien-Hsun Lee, Reu-Sheng Sheu