Patents by Inventor Giovanni Marras

Giovanni Marras has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS OF PREPARING ARACHIDONOYLETHANOLAMINE ANALOGUES
    Publication number: 20230064920
    Abstract: The present application provides new processes for preparing arachidonoylethanolamine analogues. Intermediates useful for preparing the compounds are also provided.
    Type: Application
    Filed: November 20, 2020
    Publication date: March 2, 2023
    Applicant: TRAVECTA THERAPEUTICS PTE. LTD.
    Inventors: Mahmood AHMED, Sing Yeung Frankie MAK, Ravi Kumar PUTHUKANOORI, Sampath Kumar NANGUNOORI, Ramana Murthy Venkata APPALA, Narendar VENNU, Filippo ROMOLI, Giovanni MARRAS
  • Process for the preparation of sphingosine-1-phosphate receptor agonist
    Patent number: 11465977
    Abstract: Industrially viable and advantageous processes for the preparation of Ozanimod are described. The invention also discloses the intermediates obtained in the process.
    Type: Grant
    Filed: September 25, 2019
    Date of Patent: October 11, 2022
    Assignee: QUÍMICA SINTÉTICA, S.A.
    Inventors: Giuseppe Barreca, Luca Carcone, Maurizio Taddei, Damian Mark Grainger, Samantha Louise Staniland, Claudio Cianferotti, Giovanni Marras
  • PROCESS FOR THE PREPARATION OF SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST
    Publication number: 20220033365
    Abstract: Industrially viable and advantageous processes for the preparation of Ozanimod are described. The invention also discloses the intermediates obtained in the process.
    Type: Application
    Filed: September 25, 2019
    Publication date: February 3, 2022
    Applicant: QUÍMICA SINTÉTICA, S.A.
    Inventors: Giuseppe BARRECA, Luca CARCONE, Maurizio TADDEI, Damian Mark GRAINGER, Samantha Louise STANILAND, Claudio CIANFEROTTI, Giovanni MARRAS
  • Resolution of racemic beta-aminosulfone compounds
    Patent number: 11149003
    Abstract: It is described an industrially viable and advantageous process for the preparation of (S)-beta-aminosulfone (1) starting from the corresponding racemic compound, said (S)-beta-aminosulfone being a useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: October 19, 2021
    Assignee: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giovanni Marras, Bruno Romanò
  • RESOLUTION OF RACEMIC BETA-AMINOSULFONE COMPOUNDS
    Publication number: 20200199072
    Abstract: It is described an industrially viable and advantageous process for the preparation of (S)-beta-aminosulfone (1) starting from the corresponding racemic compound, said (S)-beta-aminosulfone being a useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.
    Type: Application
    Filed: March 28, 2018
    Publication date: June 25, 2020
    Applicant: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giovanni Marras, Bruno Romanò
  • Racemic beta-aminosulfone compounds
    Patent number: 10689332
    Abstract: It is described an industrially viable and advantageous process for the preparation of racemic beta-aminosulfone (1), an useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: June 23, 2020
    Assignee: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giovanni Marras, Fabio Morana
  • RACEMIC BETA-AMINOSULFONE COMPOUNDS
    Publication number: 20200087254
    Abstract: It is described an industrially viable and advantageous process for the preparation of racemic beta-aminosulfone (1), an useful intermediate for the preparation of N-(2-((1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl)acetamide, also known as Apremilast, the latter being suitable for use in methods of treating, preventing and/or managing psoriasis or psoriatic arthritis.
    Type: Application
    Filed: March 28, 2018
    Publication date: March 19, 2020
    Applicant: Quimica Sintetica, S.A.
    Inventors: Giuseppe Barreca, Giovanni Marras, Fabio Morana
  • Nucleoside phosphoramidates useful for the treatment of viral infections and preparation thereof
    Patent number: 10407456
    Abstract: Two processes are described for preparing, in different diastereomeric purity degrees, the compound (S)-isopropyl-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)-phosphoryl)amino) propanoate, having the formula given below, known as Sofosbuvir and used for the treatment of hepatitis C.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: September 10, 2019
    Assignee: QUIMICA SINTETICA, S.A.
    Inventors: Giuseppe Barreca, Marcello Rasparini, Andrea Poggiali, Luca Carcone, Roberto Rocco Tufaro, Giovanni Marras, Maurizio Taddei, Elena Cini
  • NUCLEOSIDE PHOSPHORAMIDATES USEFUL FOR THE TREATMENT OF VIRAL INFECTIONS AND PREPARATION THEREOF
    Publication number: 20180118776
    Abstract: Two processes are described for preparing, in different diastereomeric purity degrees, the compound (S)-isopropyl-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)-phosphoryl)amino) propanoate, having the formula given below, known as Sofosbuvir and used for the treatment of hepatitis C.
    Type: Application
    Filed: March 25, 2016
    Publication date: May 3, 2018
    Inventors: Giuseppe BARRECA, Marcello RASPARINI, Andrea POGGIALI, Luca CARCONE, Roberto Rocco TUFARO, Giovanni MARRAS, Maurizio TADDEI, Elena CINI
  • One step process for preparing cross-linked poly(allylamine) polymers
    Patent number: 8394416
    Abstract: The present invention relates to a novel one step process for preparing cross-linked poly(allylamine) polymers or salts thereof using the novel cross-linking agent of Formula (IV). This invention also relates to the compound of Formula (IV) as well as to a process to obtain it. The cross-linked poly(allylamine) polymers of the invention are useful in medicine as substrate-binding polymers.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: March 12, 2013
    Assignee: Chemo Ibérica, S.A.
    Inventors: Sabrina Bianchi, Valter Castelvetro, Giovanni Marras, Sonja Bellomi, Graziano Castaldi, Gianpiero Ventimiglia
  • Novel one step process for preparing cross-linked poly(allylamine) polymers
    Publication number: 20100183732
    Abstract: The present invention relates to a novel one step process for preparing cross-linked poly(allylamine) polymers or salts thereof using the novel cross-linking agent of Formula (IV). This invention also relates to the compound of Formula (IV) as well as to a process to obtain it. The cross-linked poly(allylamine) polymers of the invention are useful in medicine as substrate-binding polymers.
    Type: Application
    Filed: July 16, 2008
    Publication date: July 22, 2010
    Inventors: Sabrina Bianchi, Valter Castelvetro, Giovanni Marras, Sonja Bellomi, Graziano Castaldi, Gianpiero Ventimiglia