Patents by Inventor Giovanni Paganelli

Giovanni Paganelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230414861
    Abstract: Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.
    Type: Application
    Filed: August 14, 2023
    Publication date: December 28, 2023
    Applicant: BetaGlue Technologies S.p.A
    Inventors: Antonino Amato, Giovanni Paganelli
  • Patent number: 11724023
    Abstract: Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.
    Type: Grant
    Filed: August 31, 2022
    Date of Patent: August 15, 2023
    Assignee: BetaGlue Technologies S.p.A
    Inventors: Antonino Amato, Giovanni Paganelli
  • Publication number: 20230079546
    Abstract: Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.
    Type: Application
    Filed: August 31, 2022
    Publication date: March 16, 2023
    Applicant: BetaGlue Technologies S.p.A
    Inventors: Antonino Amato, Giovanni Paganelli
  • Patent number: 11464897
    Abstract: Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.
    Type: Grant
    Filed: October 11, 2021
    Date of Patent: October 11, 2022
    Assignee: BETAGLUE TECHNOLOGIES S.P.A
    Inventors: Antonino Amato, Giovanni Paganelli
  • Publication number: 20220096734
    Abstract: Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.
    Type: Application
    Filed: October 11, 2021
    Publication date: March 31, 2022
    Applicant: BetaGlue Technologies S.p.A
    Inventors: Antonino Amato, Giovanni Paganelli
  • Patent number: 11141526
    Abstract: Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: October 12, 2021
    Assignee: BetaGlue Technologies S.p.A
    Inventors: Antonino Amato, Giovanni Paganelli
  • Publication number: 20210128819
    Abstract: Systems, kits and methods for preparing an injection system and/or treating target lesions with a selective internal radiation therapy which includes a double-barrel syringe loaded with a two-component tissue glue and radioisotope loaded microspheres. The microspheres are loaded into the syringe based on the size of the target location and are administered with a needle or dual-lumen catheter. Dosing regimens for treating breast cancer lesions or surgical beds up to 130 mm in diameter and hepatocellular carcinoma lesions up to 50 mm are included.
    Type: Application
    Filed: May 11, 2020
    Publication date: May 6, 2021
    Inventors: Antonino Amato, Giovanni Paganelli
  • Publication number: 20130330276
    Abstract: A conjugate of human albumin (HA) and 2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (p-SCN-Bn-DOTA) insoluble in aqueous medium at a pH of 3-8.5 and whose IR spectrum shows an absorption at about 700 cm?1 is described; a complex is further described consisting of a conjugate of HA and p-SCN-Bn-DOTA (HAC) according to claim 1 or 2 and a radioactive isotope of an element selected among the group consisting of P, Sr, Rh, Pd, I, Sm, Er, Au, At Bi, In, Lu, Y, Re, Cu and Ag, as well as procedures for preparing said conjugate and said complex as well as the use of such conjugate in the identification of mammalian neoplastic lesions by the R.O.L.L. methodology (“Radioguided Occult Lesion Localization”).
    Type: Application
    Filed: December 23, 2011
    Publication date: December 12, 2013
    Applicants: ISTITUTO EUROPEO DI ONCOLOGIA S.R.L., UNIVERSITÀ DEGLI STUDI DI GENOVA
    Inventors: Gabriele Caviglioli, Brunella Parodi, Sergio Cafaggi, Eleonora Russo, Paola Cirrincione, Marco Chinol, Giovanni Paganelli
  • Patent number: 8292869
    Abstract: A container for a vial of radiopharmaceutical, made of polymethyl methacrylate consists of a receptacle, with a cavity capable of containing the vial of radiopharmaceutical, and of a lid screwed onto the receptacle for closing the container, said lid presenting a central through-hole. A set, in combination with this container with the vial of radiopharmaceutical, consisting of a bottle of saline solution and two infusion catheters, enhances the radioprotection during the infusion of a radiopharmaceutical in an infusion operation.
    Type: Grant
    Filed: July 14, 2010
    Date of Patent: October 23, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
    Inventors: Giovanni Paganelli, Marco Chinol
  • Patent number: 8044081
    Abstract: Formula (I) compounds are described where the groups are as defined here below, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particularly for the diagnosis and therapy of pathological conditions such as tumours.
    Type: Grant
    Filed: November 27, 2007
    Date of Patent: October 25, 2011
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Giovanni Paganelli, Marco Chinol, Mauro Ginanneschi
  • Patent number: 7935346
    Abstract: The present invention describes the use of an agent endowed with tumour tropism in combination with another agent with anticancer activity and with an affinity for the first agent for the preparation of a medicament useful for the two-step perioperative therapy of solid tumours. The advantages of the present invention consist in the greater, effective localisation of its anticancer activity, in the reduction of the number of administration steps and in the possibility of reducing the anticancer doses, with a resulting decrease in side effects, but without any loss of efficacy.
    Type: Grant
    Filed: April 7, 2004
    Date of Patent: May 3, 2011
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Giovanni Paganelli, Paolo Carminati, Umberto Veronesi
  • Patent number: 7842023
    Abstract: A container for a vial of radiopharmaceutical, made of polymethyl methacrylate consists of a receptacle, with a cavity capable of containing the vial of radiopharmaceutical, and of a lid screwed onto the receptacle for closing the container, said lid presenting a central through-hole. A set, in combination with this container with the vial of radiopharmaceutical, consisting of a bottle of saline solution and two infusion catheters, enhances the radioprotection during the infusion of a radiopharmaceutical in an infusion operation.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: November 30, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Marco Chinol, Giovanni Paganelli
  • Publication number: 20100280302
    Abstract: A container for a vial of radiopharmaceutical, made of polymethyl methacrylate consists of a receptacle, with a cavity capable of containing the vial of radiopharmaceutical, and of a lid screwed onto the receptacle for closing the container, said lid presenting a central through-hole. A set, in combination with this container with the vial of radiopharmaceutical, consisting of a bottle of saline solution and two infusion catheters, enhances the radioprotection during the infusion of a radiopharmaceutical in an infusion operation.
    Type: Application
    Filed: July 14, 2010
    Publication date: November 4, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE S.P.A.
    Inventors: Marco Chinol, Giovanni Paganelli
  • Patent number: 7816388
    Abstract: Formula (I) compounds are described: Formula (I) where the radicals are as defined in the description, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particularly for the diagnosis and therapy of pathological conditions such as tumors.
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: October 19, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Mauro Ginanneschi, Giovanni Paganelli, Marco Chinol
  • Publication number: 20080249152
    Abstract: Formula (I) compounds are described: Formula (I) where the radicals are as defined in the description, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particularly for the diagnosis and therapy of pathological conditions such as tumours.
    Type: Application
    Filed: September 18, 2006
    Publication date: October 9, 2008
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Paolo Carminati, Mauro Ginanneschi, Giovanni Paganelli, Marco Chinol
  • Patent number: 7390828
    Abstract: Formula (I) compounds are described where the groups are as defined here below, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particularly for the diagnosis and therapy of pathological conditions such as tumours
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: June 24, 2008
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Giovanni Paganelli, Marco Chinol, Mauro Ginanneschi
  • Publication number: 20080085239
    Abstract: Formula (I) compounds are described where the groups are as defined here below, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particularly for the diagnosis and therapy of pathological conditions such as tumours.
    Type: Application
    Filed: November 27, 2007
    Publication date: April 10, 2008
    Inventors: Giovanni Paganelli, Marco Chinol, Mauro Ginanneschi
  • Publication number: 20060251579
    Abstract: The present invention describes the use of an agent endowed with tumour tropism in combination with another agent with anticancer activity and with an affinity for the first agent for the preparation of a medicament useful for the two-step perioperative therapy of solid tumours. The advantages of the present invention consist in the greater, effective localisation of its anticancer activity, in the reduction of the number of administration steps and in the possibility of reducing the anticancer doses, with a resulting decrease in side effects, but without any loss of efficacy.
    Type: Application
    Filed: April 7, 2004
    Publication date: November 9, 2006
    Inventors: Giovanni Paganelli, Paolo Carminati, Umberto Veronesi
  • Publication number: 20050154275
    Abstract: A container for a vial of radiopharmaceutical, made of polymethyl methacrylate consists of a receptacle, with a cavity capable of containing the vial of radiopharmaceutical, and of a lid screwed onto the receptacle for closing the container, said lid presenting a central through-hole. A set, in combination with this container with the vial of radiopharmaceutical, consisting of a bottle of saline solution and two infusion catheters, enhances the radioprotection during the infusion of a radiopharmaceutical in an infusion operation.
    Type: Application
    Filed: February 3, 2003
    Publication date: July 14, 2005
    Inventors: Marco Chinol, Giovanni Paganelli
  • Publication number: 20040067199
    Abstract: Formula (I) compounds are described where the groups are as defined here below, processes for their preparation, and their uses for the preparation of conjugates with radionuclides for use in human and animal therapy and diagnostics, particularly for the diagnosis and therapy of pathological conditions such as tumours.
    Type: Application
    Filed: September 30, 2003
    Publication date: April 8, 2004
    Inventors: Giovanni Paganelli, Marco Chinol, Mauro Ginanneschi