Patents by Inventor Giovanni Vozzi

Giovanni Vozzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11945161
    Abstract: A combined electrospinning and microextrusion apparatus includes a robotic manipulator having a plurality of degrees of freedom, an end effector supported and movable by the robotic manipulator, a plurality of extruders housed on the end effector, each extruder having an interchangeable nozzle for extrusion of material, a working plane for deposition of extruded material, a pneumatic circuit supplying a fluid flow to the extruders for controlling extrusion of material, and an electric generator selectively activatable to apply a potential difference between the nozzles of the extruders and the working plane. The extruders are capable of operating selectively in microextrusion mode with inactive electric generator or in electrospinning mode with active electric generator, in an independent manner from each other.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: April 2, 2024
    Assignee: UNIVERSITA' DI PISA
    Inventors: Giovanni Vozzi, Aurora De Acutis, Carmelo De Maria, Guglielmo Pacetta
  • Publication number: 20210053284
    Abstract: A combined electrospinning and microextrusion apparatus includes a robotic manipulator having a plurality of degrees of freedom, an end effector supported and movable by the robotic manipulator, a plurality of extruders housed on the end effector, each extruder having an interchangeable nozzle for extrusion of material, a working plane for deposition of extruded material, a pneumatic circuit supplying a fluid flow to the extruders for controlling extrusion of material, and an electric generator selectively activatable to apply a potential difference between the nozzles of the extruders and the working plane. The extruders are capable of operating selectively in microextrusion mode with inactive electric generator or in electrospinning mode with active electric generator, in an independent manner from each other.
    Type: Application
    Filed: May 3, 2019
    Publication date: February 25, 2021
    Inventors: Giovanni VOZZI, Aurora DE ACUTIS, Carmelo DE MARIA, Guglielmo PACETTA
  • Patent number: 9243220
    Abstract: Embodiments of the invention provide a chamber for a bioreactor, the chamber having a fluid inlet aperture and a fluid outlet aperture disposed at respective different locations of a wall of the chamber, with respect to a normal upright orientation of the chamber the chamber being provided with an upper wall portion defining an upper boundary of the chamber. The upper wall portion has an internal surface having a first portion that is vertically displaced with respect to a second portion. The internal surface of the upper wall portion is arranged to promote expulsion of trapped gas bubbles through the outlet aperture, the first and second portions of the upper wall portion each comprising a sloped portion.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: January 26, 2016
    Assignee: Kirkstall Limited
    Inventors: Arti Ahluwalia, Daniele Mazzei, Bruna Vinci, Giovanni Vozzi
  • Patent number: 8715436
    Abstract: The invention is a series of soft lithographic methods for the microfabrication of biopolymer scaffolds for use in tissue engineering and the development of artificial organs. The methods present a wide range of possibilities to construct two- and three-dimensional scaffolds with desired characteristics according to the final application. The methods utilize an elastomer mold which the biopolymer scaffold is cast. The methods allow for the rapid and inexpensive production of biopolymer scaffolds with limited specialized equipment and user expertise.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: May 6, 2014
    Assignee: The Regents of the University of California
    Inventors: Sangeeta N. Bhatia, Giovanni Vozzi
  • Publication number: 20130230907
    Abstract: A bioreactor (1) for subjecting a cell culture (3) to a hydrodynamic pressure stimulus is described. This hydrodynamic pressure is generated inside at least one culture chamber (2) by means of variation of the mean distance, with a controlled speed, of a surface relative to the surface on which the culture (3) is positioned and between which the culture medium (5) is free to flow.
    Type: Application
    Filed: April 21, 2010
    Publication date: September 5, 2013
    Inventors: Arti Ahluwalia, Carmelo De Maria, Daniele Mazzei, Giovanni Vozzi
  • Publication number: 20110129911
    Abstract: Embodiments of the invention provide a chamber for a bioreactor, the chamber having a fluid inlet aperture and a fluid outlet aperture disposed at respective different locations of a wall of the chamber, with respect to a normal upright orientation of the chamber the chamber being provided with an upper wall portion defining an upper boundary of the chamber. The upper wall portion has an internal surface having a first portion that is vertically displaced with respect to a second portion. The internal surface of the upper wall portion is arranged to promote expulsion of trapped gas bubbles through the outlet aperture, the first and second portions of the upper wall portion each comprising a sloped portion.
    Type: Application
    Filed: July 31, 2009
    Publication date: June 2, 2011
    Inventors: Arti Ahluwalia, Daniele Mazzei, Bruna Vinci, Giovanni Vozzi
  • Patent number: 7790444
    Abstract: A bioreactor device for studying the effects of physical, chemical, mechanical and electromagnetic stimuli on the cellular activity. In particular, the device uses a sensorized premixing chamber (1), a culture chamber (2) for observing the development of the cells by a microscope (40). Output signals are transmitted to a control unit for amplifying and filtering the signals (50), which transmits the treated signals to a computer (52). To another control unit (51) actuating electrovalves (20), (21) and (22) are connected that adjust the introduction of gas in the premixing chamber. The culture medium is drawn from the premixing chamber (1) through a duct (4) and its flow is adjusted by a peristaltic pump (30). The culture medium crosses then the culture chamber (2) and continues its path in a duct (3), returning again in the premixing chamber (1). At the outlet of the culture chamber (2) the duct has a sample point (23) for picking up an amount of culture medium to analyze.
    Type: Grant
    Filed: June 16, 2005
    Date of Patent: September 7, 2010
    Assignee: Universita' Degli Studi di Pisa
    Inventors: Arti Ahluwalia, Federico Vozzi, Giovanni Vozzi, Nicola Forgione, Antonino Previti, Valerio Rossi, Cristiano Scarpa
  • Publication number: 20080274539
    Abstract: A bioreactor device for studying the effects of physical, chemical, mechanical and electromagnetic stimuli on the cellular activity. In particular, the device uses a sensorized premixing chamber (1), a culture chamber (2) for observing the development of the cells by a microscope (40). Output signals are transmitted to a control unit for amplifying and filtering the signals (50), which transmits the treated signals to a computer (52). To another control unit (51) actuating electrovalves (20), (21) and (22) are connected that adjust the introduction of gas in the premixing chamber. The culture medium is drawn from the premixing chamber (1) through a duct (4) and its flow is adjusted by a peristaltic pump (30). The culture medium crosses then the culture chamber (2) and continues its path in a duct (3), returning again in the premixing chamber (1). At the outlet of the culture chamber (2) the duct has a sample point (23) for picking up an amount of culture medium to analyse.
    Type: Application
    Filed: June 16, 2005
    Publication date: November 6, 2008
    Inventors: Arti Ahluwalia, Federico Vozzi, Giovanni Vozzi, Nicola Forgione, Antonio Previti, Valerio Rossi, Cristiano Scarpa
  • Publication number: 20050008675
    Abstract: The invention is a series of soft lithographic methods for the microfabrication of biopoilymer scaffolds for use in tissue engineering and the development of artificial organs. The methods present a wide range of possibilities to construct two- and three-dimensional scaffolds with desired characteristics according to the final application. The methods utilize an elastomer mold which the biopolymer scaffold is cast. The methods allow for the rapid and inexpensive production of biopolymer scaffolds with limited specialized equipment and user expertise.
    Type: Application
    Filed: December 31, 2003
    Publication date: January 13, 2005
    Inventors: Sangeeta Bhatia, Giovanni Vozzi