Abstract: The present disclosure is directed to materials, devices, and methods for resonant ambient thermal energy harvesting. Thermal energy can be harvested using thermoelectric resonators that capture and store ambient thermal fluctuations and convert the fluctuations to energy. The resonators can include non-linear heat transfer elements, such as thermal diodes, to enhance their performance. Incorporation of thermal diodes can allow for a dynamic rectification of temperature fluctuations into a single polarity temperature difference across a heat engine for power extraction, as compared to the dual polarity nature of the output voltage of linear thermal resonators, which typically necessitates electrical rectification to be routed to an entity for energy storage. In some embodiments, the thermal diode can be applied to transient energy harvesting to construct thermal diode bridges. Methods for constructing such devices, and using such devices, are also provided.

Abstract: The present disclosure is directed to materials, devices, and methods for resonant ambient thermal energy harvesting. Thermal energy can be harvested using thermoelectric resonators that capture and store ambient thermal fluctuations and convert the fluctuations to energy. The thermal resonators can include heat engines disposed between masses of varying sizes or diodes. The masses or diodes can be made of high and ultra-high effusivity materials to transfer thermal energy through the resonator and optimize power output. The masses or diodes of the resonator can be tuned to the dominant frequency of the temperature waveform to maximize the amount of energy being converted. The resonators can be added to existing structures to supply or generate power, and, in some embodiments, the structures themselves can be a mass of the thermal resonator. Methods for constructing and/or using such devices are also provided, as are methods for formulating ultra-high effusivity materials.

Abstract: The present invention relates to fused pyrimidines of formulae I and II wherein, R1, R2 are as herein described. The present invention particularly relates to isoform selective PI3K? inhibition and their medicinal use as anticancer agents.

Abstract: The present invention relates to fused pyrimidines of formulae I and II wherein, R1, R2 are as herein described. The present invention particularly relates to isoform selective PI3K? inhibition and their medicinal use as anticancer agents.

Abstract: The present disclosure is directed to materials, devices, and methods for resonant ambient thermal energy harvesting. Thermal energy can be harvested using thermoelectric resonators that capture and store ambient thermal fluctuations and convert the fluctuations to energy. The resonators can include non-linear heat transfer elements, such as thermal diodes, to enhance their performance. Incorporation of thermal diodes can allow for a dynamic rectification of temperature fluctuations into a single polarity temperature difference across a heat engine for power extraction, as compared to the dual polarity nature of the output voltage of linear thermal resonators, which typically necessitates electrical rectification to be routed to an entity for energy storage. In some embodiments, the thermal diode can be applied to transient energy harvesting to construct thermal diode bridges. Methods for constructing such devices, and using such devices, are also provided.

Abstract: The present disclosure is directed to materials, devices, and methods for resonant ambient thermal energy harvesting. Thermal energy can be harvested using thermoelectric resonators that capture and store ambient thermal fluctuations and convert the fluctuations to energy. The thermal resonators can include heat engines disposed between masses of varying sizes or diodes. The masses or diodes can be made of high and ultra-high effusivity materials to transfer thermal energy through the resonator and optimize power output. The masses or diodes of the resonator can be tuned to the dominant frequency of the temperature waveform to maximize the amount of energy being converted. The resonators can be added to existing structures to supply or generate power, and, in some embodiments, the structures themselves can be a mass of the thermal resonator. Methods for constructing and/or using such devices are also provided, as are methods for formulating ultra-high effusivity materials.

Abstract: The present invention describes heterocyclic compounds of general Formula 1 and their method of preparation thereof. The present invention describes general Formula 1 which inhibits phosphoinositide 3-kinase (PI3K) and can be used as the anticancer agents.

Abstract: The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.

Abstract: The present invention describes heterocyclic compounds of general Formula 1 and their method of preparation thereof. The present invention describes general Formula 1 which inhibits phosphoinositide 3-kinase (PI3K) and can be used as the anticancer agents.

Abstract: The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.