Abstract: Nontoxic sustained release pharmaceutical compositions containing one or more nonionic, lipophilic drugs in a cured low temperature vulcanizable (LTV) silicone elastomer excipient are prepared substantially free of toxic vulcanizing agents or drug-reactive by-products in the elastomeric material by curing an admixture of the drug or drug containing core, LTV-methylvinylsiloxane units containing linear dimethylpolysiloxane and a dimethylpolysiloxane crosslinking composition containing silicon linked H atoms using a noble metal-based catalyst. The resultant compositions are characterized by good physical properties and a constant rate of drug release in the body over long periods of time.

Abstract: A composite vaginal ring containing a safe and effective amount of a pharmaceutically active medicament, which comprises:(a) a major supporting vaginal ring consisting essentially of a physiologically acceptable synthetic resin and having at least a portion of the annular surface thereof adapted to mate with corresponding minor, medicament-containing vaginal ring segment; and(b) at least one minor, medicament-containing vaginal ring segment adapted to mate with the modified annular surface of said major supporting vaginal ring and consisting essentially of a safe and effective amount of a pharmaceutically active amount of a nonionic, lipophilic drug dissolved or uniformly suspended in an elastomeric, cross-linked LTV linear dimethylpolysiloxane resin.

Abstract: A Y-shaped medicated contraceptive IUD for human use having a pair of elastomeric arms rounded at the ends thereof to facilitate insertion and removal, and a base containing protrusions to aid in gripping of the device by the cervix muscles. The device is adaptable to virtually any size human uterus and shows fewer side effects and spontaneous expulsions than known IUD's.

Abstract: A composite vaginal ring containing a safe and effective amount of a pharmaceutically active medicament, which comprises:A. a major supporting vaginal ring consisting essentially of a physiologically acceptable synthetic resin and having at least a portion of the annular surface thereof adapted to mate with corresponding minor, medicament-containing vaginal ring segment; andB. at least one minor, medicament-containing vaginal ring segment adapted to mate with the modified annular surface of said major supporting vaginal ring and consisting essentially of a safe and effective amount of a pharmaceutically active amount of a nonionic, lipophilic drug dissolved or uniformly suspended in an elastomeric, cross-linked LTV linear dimethylpolysiloxane resin.

Abstract: Nontoxic sustained release pharmaceutical compositions containing one or more nonionic, lipophilic drugs in a cured low temperature vulcanizable (LTV) silicone elastomer excipient are prepared substantially free of toxic vulcanizing agents or drug-reactive by-products in the elastomeric material by curing with a vulcanizable composition comprisingA. a polydimethylsiloxane having vinyl groups on both ends;B. a copolymer consisting essentially of SiO.sub.2 units, (CH.sub.3).sub.3 SiO.sub.0.5 units, Vinyl(CH.sub.3).sub.2 SiO.sub.0.5 units; andC. a cross-linking Si-H component, consisting essentially of (CH.sub.3).sub.3 SiO.sub.0.5 units, (CH.sub.3).sub.2 SiO units, and CH.sub.3 HSiO units.The resultant compositions are characterized by good physical properties and a constant rate of drug release in the body over long periods of time.