Abstract: Physically and chemically stable oral liquid formulations of Givinostat (Diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride) are disclosed, together with methods for the preparation thereof. Such oral formulations are in the form of aqueous suspensions and contain Givinostat and/or pharmaceutically acceptable salts and/or derivatives thereof, at least a wetting agent and/or at least a density-imparting agent. Such formulations are suitable for oral administration for systemic therapeutic action.

Abstract: Physically and chemically stable oral liquid formulations of Givinostat (Diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride) are disclosed, together with methods for the preparation thereof. Such oral formulations are in the form of aqueous suspensions and contain Givinostat and/or pharmaceutically acceptable salts and/or derivatives thereof, at least a wetting agent and/or at least a density-imparting agent. Such formulations are suitable for oral administration for systemic therapeutic action.

Abstract: An apparatus for continuously introducing a substance in liquid phase into plastics granules includes a supporting structure adapted to support in series and in substantial vertical alignment a feeding section, at least one mixing chamber, and at least one drying chamber. The feeding section is provided with means for feeding the granules to at least one spraying chamber provided with means for spraying the substance onto the granules. The at least one mixing chamber of the granules partially or totally coated with the substance includes substantially static mixing means supported in the at least one mixing chamber. The at least one drying chamber is adapted to receive a predetermined amount of the granules coated with the substance. The substantially static mixing means may include, for example, at least one static mixer, a plurality of mixing bars, or at least two superimposed groups of mixing bars.

Abstract: In a hub-bearing assembly for the wheel of a motor vehicle, the hub (1) forms integrally or is fixedly secured to a radial flange (7) fixable to a wheel (8). Associated with the assembly is a measuring device (14) mounted to a non-rotating part (12) of the vehicle and operatively facing a radial surface (13) integral with the flange (7). The measuring device (14) detects in real time variations of the axial position of the surface (13) caused by elastic deformation of the flange (7) provoked by forces transmitted from the wheel (8) to the hub flange (7).

Abstract: An apparatus for introducing in continuous a substance in liquid phase into plastics granules comprising: a) feeding a substantially continuous flow of the plastics granules to at least one substantially static spraying chamber, b) spraying the substance in liquid phase onto the plastics granules, c) passing the granules partially or totally coated by the substance in liquid phase by a substantially static mixing means supported in at least one mixing chamber provided downstream of the spraying chamber, d) submitting the mixed granules to drying for a time sufficient to allow a substantially complete absorption of the substance in liquid phase by the granules.

Abstract: A method for continuously introducing a substance in liquid phase into plastics granules comprising: a) feeding a substantially continuous flow of the plastics granules to at least one substantially static spraying chamber, b) spraying the substance in liquid phase onto the plastics granules, c) passing the granules partially or totally coated by the substance in liquid phase by a substantially static mixing means supported in at leas one mixing chamber provided downstream of the spraying chamber, d) submitting the mixed granules to drying for a time sufficient to allow a substantially complete absorption of the substance in liquid phase by the granules.

Abstract: In a hub-bearing assembly for the wheel of a motor vehicle, the hub (1) forms integrally or is fixedly secured to a radial flange (7) fixable to a wheel (8). Associated with the assembly is a measuring device (14) mounted to a non-rotating part (12) of the vehicle and operatively facing a radial surface (13) integral with the flange (7). The measuring device (14) detects in real time variations of the axial position of the surface (13) caused by elastic deformation of the flange (7) provoked by forces transmitted from the wheel (8) to the hub flange (7).

Abstract: A pharmaceutical aqueous suspension formulation for parenteral administration having substantially stabilized pH, comprising a biologically active compound and a pH controlling effective concentration of a polyvinylpyrrolidone compound. Preferably the biologically active compound is a steroidal compound, for instance, exemestane, medroxyprogesterone acetate or estradiol cypionate or a combination of medroxyprogesterone acetate and estradiol cypionate.

Abstract: A pharmaceutical aqueous suspension formulation for parenteral administration having substantially stabilized pH, comprising a biologically active compound and a pH controlling effective concentration of L-Methionine. Preferably, the biologically active compound is a steroidal compound, for instance exemestane, medroxyprogesterone acetate and estradiol cypionate or a combination of medroxyprogesterone acetate and estradiol cypionate.

Abstract: A pharmaceutical aqueous suspension formulation for parenteral administration having substantially stabilized pH, comprising a biologically active compound and a pH controlling effective concentration of L-Methionine. Preferably, the biologically active compound is a steroidal compound, for instance exemestane, medroxyprogesterone acetate and estradiol cypionate or a combination of medroxyprogesterone acetate and estradiol cypionate.

Abstract: A pharmaceutical aqueous suspension formulation for parenteral administration having substantially stabilized pH, comprising a biologically active compound and a pH controlling effective concentration of L-Methionine.

Abstract: The invention relates to a method and an apparatus for introducing in continuous a substance in liquid phase into plastics granules by means of the steps of:

Abstract: The present invention provides a pharmaceutical composition comprising an estramustine derivative and a cyclodextrin, particularly in the manufacture of a medicament suitable for the oral administration of an estramustine derivative to a patient suffering from a tumor.Estramustine derivatives according to the invention are, for example, compounds of general formula (I) ##STR1## wherein R is ##STR2## in which R.sub.1 is C.sub.1 -C.sub.4 alkyl and n is 0, 1 or 2, and the pharmaceutically acceptable salts thereof.

Abstract: There is disclosed a system by which a satellite is connected by means of a long tether, typically a wire 100 km or more in length, to a powered spacecraft. The spacecraft may be the Space Shuttle, and two basic equilibrium positions of the system are discussed. The wire is gradually released from a storage drum aboard the powered spacecraft, and the gravity gradient established along with atmospheric drag provide the force for deployment. The system can be used repeatedly by reeling back onto the drum. The wire, once deployed, can then be left in orbit for use in future shuttle missions and (once reeled back) can be returned to earth for repair or replacement. The tethered system finds utilization in the broad areas of upper atmosphere measurements, gravity gradient measurements and radio physics research.