Patents by Inventor Glen R. Nemerow

Glen R. Nemerow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vault complexes for facilitating biomolecule delivery
    Patent number: 9181312
    Abstract: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: November 10, 2015
    Assignees: The Regents of the University of California, The Scripps Research Institute
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Glen R. Nemerow, Cheng-Yu Lai, Chris M. Weithoff, Mu Ri Han
  • Vault Complexes for Facilitating Biomolecule Delivery
    Publication number: 20130344564
    Abstract: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.
    Type: Application
    Filed: September 4, 2013
    Publication date: December 26, 2013
    Applicants: The Scripps Research Institute, The Regents of the University of California
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Glen R. Nemerow, Cheng-Yu Lai, Chris M. Weithoff, Mu Ri Han
  • Vault complexes for facilitating biomolecule delivery
    Patent number: 8551781
    Abstract: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: October 8, 2013
    Assignees: The Regents of the University of California, The Scripps Research Institute
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Glen R. Nemerow, Cheng-Yu Lai, Christopher M. Wiethoff, Mu Ri Han
  • Vault Complexes for Facilitating Biomolecule Delivery
    Publication number: 20110201112
    Abstract: The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and methods of using the vault complexes to facilitate delivery and entry of a biomolecule into a cell or subject.
    Type: Application
    Filed: November 19, 2010
    Publication date: August 18, 2011
    Applicant: The Regents of the University of California
    Inventors: Leonard H. Rome, Valerie A. Kickhoefer, Glen R. Nemerow, Cheng-Yu Lai, Christopher M. Wiethoff, Mu Ri Han
  • Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use
    Publication number: 20090098599
    Abstract: The present invention relates to methods for gene therapy, especially to adenovirus-based gene therapy, and related cell lines and compositions. In particular, novel nucleic acid constructs and packaging cell lines are disclosed, for use in facilitating the development of high-capacity and targeted vectors. The invention also discloses a variety of high-capacity adenovirus vectors and related compositions and kits including the disclosed cell lines and vectors. Finally, the invention discloses methods of preparing and using the disclosed vectors, cell lines and kits.
    Type: Application
    Filed: June 18, 2007
    Publication date: April 16, 2009
    Inventors: Daniel J. Von Seggern, Glen R. Nemerow, Paul Hallenbeck, Susan Stevenson, Yelena Skripchenko
  • Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use
    Patent number: 7232899
    Abstract: The present invention relates to methods for gene therapy, especially to adenovirus-based gene therapy, and related cell lines and compositions. In particular, novel nucleic acid constructs and packaging cell lines are disclosed, for use in facilitating the development of high-capacity and targeted vectors. The invention also discloses a variety of high-capacity adenovirus vectors and related compositions and kits including the disclosed cell lines and vectors. Finally, the invention discloses methods of preparing and using the disclosed vectors, cell lines and kits.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: June 19, 2007
    Assignee: The Scripps Research Institute
    Inventors: Daniel J. Von Seggern, Glen R. Nemerow
  • Methods and compositions useful for targeting activated vitronectin receptor alphavbeta3
    Publication number: 20040005550
    Abstract: The present invention provides ligands which can selectively bind to activated &agr;v&bgr;3 integrin. A novel monovalent ligand-mimetic (WOW-1 Fab) which includes a single &agr;v integrin-binding domain from multivalent adenovirus penton base is provided. Further, the present invention describes particular compositions of activated &agr;v&bgr;3-specific ligands, such as an antibody which immunoreacts preferentially with activated &agr;v&bgr;3 integrin. The invention also describes methods using an activated &agr;v&bgr;3-specific ligand for diagnostic detection of activated &agr;v&bgr;3 integrin in tissues and for the targeted delivery of therapeutic agents to tissues containing activated &agr;v&bgr;3 integrin.
    Type: Application
    Filed: June 3, 2003
    Publication date: January 8, 2004
    Applicant: The Scripps Research Institute
    Inventors: Sanford J. Shattil, Glen R. Nemerow, Takaaki Hato, Dwayne G. Stupack, Nisar A. Pampori
  • Fiber shaft modifications for efficient targeting
    Publication number: 20040002060
    Abstract: Provided are adenoviral vectors and the production of such vectors. In particular, fiber shaft modifications for efficient targeting of adenoviral vectors are provided. The fiber shaft modifications can be combined with other modifications, such as fiber knob and/or penton modifications, to produce fully ablated (detargeted) adenoviral vectors. A scale-up method for the propagation of detargeted adenoviral vectors is also provided.
    Type: Application
    Filed: January 24, 2003
    Publication date: January 1, 2004
    Applicants: Novartis AG, The Scripps Research Institute
    Inventors: Michael Kaleko, Glen R. Nemerow, Theodore Smith, Susan C. Stevenson
  • Fiber shaft modifications for efficient targeting
    Publication number: 20030215948
    Abstract: Provided are adenoviral vectors and the production of such vectors. In particular, fiber shaft modifications for efficient targeting of adenoviral vectors are provided. The fiber shaft modifications can be combined with other modifications, such as fiber knob and/or penton modifications, to produce fully ablated (detargeted) adenoviral vectors. A scale-up method for the propagation of detargeted adenoviral vectors is also provided.
    Type: Application
    Filed: March 27, 2003
    Publication date: November 20, 2003
    Applicants: The Scripps Research Institute, Novartis AG
    Inventors: Michael Kaleko, Glen R. Nemerow, Theodore Smith, Susan C. Stevenson
  • Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use
    Publication number: 20030157688
    Abstract: The present invention relates to methods for gene therapy, especially to adenovirus-based gene therapy, and related cell lines and compositions. In particular, novel nucleic acid constructs and packaging cell lines are disclosed, for use in facilitating the development of high-capacity and targeted vectors. The invention also discloses a variety of high-capacity adenovirus vectors and related compositions and kits including the disclosed cell lines and vectors. Finally, the invention discloses methods of preparing and using the disclosed vectors, cell lines and kits.
    Type: Application
    Filed: January 14, 2000
    Publication date: August 21, 2003
    Inventors: Daniel J. Von Seggern, Glen R. Nemerow, Paul Hallenbeck, Susan Stevenson, Yelena Skripchenko
  • Vectors for occular transduction and use therefor for genetic therapy
    Publication number: 20020193327
    Abstract: Adenovirus vector-based gene therapy methods for treating ocular disorders are provided. Adenovirus vectors for therapy of ocular diseases and methods of treatment using the vectors are provided. Compositions, kits, and methods of preparation and use of the vectors for gene therapy are provided.
    Type: Application
    Filed: May 1, 2001
    Publication date: December 19, 2002
    Applicant: The Scripps Research Institute
    Inventors: Glen R. Nemerow, Daniel J. Von Seggern, Martin Friedlander
  • Bifunctional molecules and vectors complexed therewith for targeted gene delivery
    Publication number: 20020164333
    Abstract: Methods and products for targeting delivery vectors, such as adenoviral gene delivery particles, to selected cell types are provided. The methods rely on targeting by a bifunctional molecule that specifically complexes with a protein on the vector particle surface and with targeted cell surface proteins. The targeted cell surface proteins are any that activate the phosphatidylinositol-3-OH kinases. The bifunctional molecules, compositions, kits, and methods of preparation and use of the vector/bifunctional molecules for gene therapy are provided.
    Type: Application
    Filed: July 10, 2001
    Publication date: November 7, 2002
    Applicant: The Scripps Research Institute
    Inventors: Glen R. Nemerow, Erguang Li