Patents by Inventor Glen Rennie

Glen Rennie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of preparing substituted tetracyclines with transition metal-based chemistries
    Publication number: 20040033996
    Abstract: The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds, reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention, a substituted tetracycline compound may be prepared by combining a reactive tetracycline-based precursor compound such as an arene tetracycline diazonium salt, and a reactive organic substituent precursor, e.g., alkenes, substituted alkenes, vinyl monomers, aromatics and heteroaromatics, in the presence of a transition metal catalyst, such as palladium chloride, under conditions such that a tetracycline compound substituted with the organic substituent is formed.
    Type: Application
    Filed: July 9, 2003
    Publication date: February 19, 2004
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
  • Methods of preparing substituted tetracyclines with transition metal-based chemistries
    Patent number: 6617318
    Abstract: The present invention relates to 7-phenyl substituted tetracycline derivatives and compositions thereof.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: September 9, 2003
    Assignee: Trustees of Tufts College
    Inventors: Mark L. Nelson, Glen Rennie, Darrell J. Koza
  • 13-substituted methacycline compounds
    Publication number: 20030166952
    Abstract: 13-substituted methacycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 13-substituted methacycline compounds are described.
    Type: Application
    Filed: November 1, 2002
    Publication date: September 4, 2003
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Beena Bhatia, Laura Mclntyre, Glen Rennie
  • 9-substituted minocycline compounds
    Publication number: 20030125348
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 29, 2001
    Publication date: July 3, 2003
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura McIntyre, Tadeusz Warchol, David Messersmith
  • 7-substituted tetracycline compounds
    Publication number: 20030055025
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 29, 2001
    Publication date: March 20, 2003
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
  • 13-substituted methacycline compounds
    Patent number: 6500812
    Abstract: 13-substituted methacycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 13-substituted methacycline compounds are described.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: December 31, 2002
    Assignees: Paratek Pharmaceuticals, Inc., Trustees of Tufts College
    Inventors: Mark L. Nelson, Beena Bhatia, Laura McIntyre, Glen Rennie
  • 13-substituted methacycline compounds
    Publication number: 20020147182
    Abstract: 13-substituted methacycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 13-substituted methacycline compounds are described.
    Type: Application
    Filed: June 29, 2001
    Publication date: October 10, 2002
    Inventors: Mark L. Nelson, Beena Bhatia, Laura McIntyre, Glen Rennie
  • 7-phenyl-substituted tetracycline compounds
    Publication number: 20020132798
    Abstract: 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described.
    Type: Application
    Filed: June 15, 2001
    Publication date: September 19, 2002
    Inventors: Mark L. Nelson, Glen Rennie, Darrell Koza