Abstract: A female condom is provided that includes a pouch of resilient membranous material and a hydrophilic cling mechanism. According to an embodiment of the invention, the cling mechanism includes three or more foam cling elements attached to an outer surface of the pouch. Upon insertion, the foam cling elements cling lightly to vaginal walls proximate a transition zone between the vagina's introitus and its rugated internal tissue. The foam cling elements may be shaped to permit them to nestle into a user's rugated internal vaginal tissue. An inserter may be coupled to the pouch for facilitating insertion of the condom. The inserter may retain a distal portion of the pouch in a collapsed form. The cling mechanism may be contained within the dissolvable inserter. The inserter may be dissolvable in the presence of vaginal moisture. Methods are also provided for collapsing the pouch and compressing it into an insertion package.

Abstract: Employing the known “tensegrity” principle, a female condom is configured such that when the condom is inserted into a woman's vagina, the woman's introitus acts on a proximal section of an elongated pouch extending between internal and external biasing members (e.g., rings) of the condom. Inward compressive forces exerted by the introitus on the inner ring of the condom cause the inner ring to be pushed distally within the vaginal canal, and the proximal pouch section to become a tension member pulling against the external ring. This causes a “tenting” of the proximal pouch section against the introitus. The resulting interaction of compression and tensile forces (a tensegrity effect) serves to provide the condom with a high degree of internal and external stability, including resistance to twisting and slippage.

Abstract: A female condom is provided that includes a pouch of resilient membranous material and a hydrophilic cling mechanism. According to an embodiment of the invention, the cling mechanism includes three or more foam cling elements attached to an outer surface of the pouch. Upon insertion, the foam cling elements cling lightly to vaginal walls proximate a transition zone between the vagina's introitus and its rugated internal tissue. The foam cling elements may be shaped to permit them to nestle into a user's rugated internal vaginal tissue. An inserter may be coupled to the pouch for facilitating insertion of the condom. The inserter may retain a distal portion of the pouch in a collapsed form. The cling mechanism may be contained within the dissolvable inserter. The inserter may be dissolvable in the presence of vaginal moisture. Methods are also provided for collapsing the pouch and compressing it into an insertion package.

Abstract: In a needle cannula extraction device, an engagement stroke moves one engagement member toward another engagement member so as to first engage a needle cannula inserted therebetween. Movement of at least one of the engagement members during a subsequent extraction stroke maintains a generally constant spacing between the engagement members that generally corresponds to a thickness of the needle. The extraction stroke pulls the needle cannula from its hub or other attachment structure, which is held in position. In first and second embodiments, the two engagement members first come together to grip the cannula, and then move together as a unit (with the engaged needle cannula) away from the retained attachment structure. In third and fourth embodiments, a first engagement member is pivotable toward a second engagement member, provided in the form of a backing member, and then away from the retained attachment structure.

Abstract: Employing the known “tensegrity” principle, a female condom is configured such that when the condom is inserted into a woman's vagina, the woman's introitus acts on a proximal section of an elongated pouch extending between internal and external biasing members (e.g., rings) of the condom. Inward compressive forces exerted by the introitus on the inner ring of the condom cause the inner ring to be pushed distally within the vaginal canal, and the proximal pouch section to become a tension member pulling against the external ring. This causes a “tenting” of the proximal pouch section against the introitus. The resulting interaction of compression and tensile forces (a tensegrity effect) serves to provide the condom with a high degree of internal and external stability, including resistance to twisting and slippage.

Abstract: A disposable medicine delivery unit for use in a needleless hypodermic injector is configured to allow economical replacement, after each injection, of a patient contact surface and the entire injection flow-path of the medicament, to thereby ensure sterility with less need for repeated equipment cleaning and sterilization procedures. The delivery unit includes a piston seal configured to prevent improper reuse. The piston seal deforms and sticks in a conical end of the medicine delivery chamber at the end of its injection stroke. A push-only connection between the piston seal and a piston drive rod of the injector ensures that the latter cannot be used to retract the former. Preferably, the piston seal also includes a protruding nipple which enters and destroys the injection orifice following an injection, to further disable the delivery unit.

Abstract: A contraceptive diaphragm having a rim surrounding a thin membrane, the membrane having a cervical dome extending downwardly from a posterior portion of the membrane. The rim has two curvilinear bands joined together at their respective ends and encased in a coil spring. The shape of the bands creates a rim which curves slightly upwardly at the anterior end of the diaphragm and slightly downwardly at its posterior end. The rim is formed with a curvilinear profile which provides an advantageous fit. A small dome projects upwardly from an anterior portion of the membrane which is grasped by the wearer to remove the diaphragm.

Abstract: A needleless, low pressure, air powered medicine injector with a quick disconnect medicine delivery assembly removably connected to the injector housing. Low pressure air drives a biased piston through a discharge stroke, beginning from the retracted position into the medicine chamber, thereby forcing medicine through a one-piece nozzle. A removable chamber filling mechanism connected to the housing is coupled to the medicine chamber through fill ports, such that the medicine chamber is filled utilizing a positive pressure medicine distributor. A movable spacer collar positioned in front of the nozzle provides an air gap between a patient's skin and the one-piece nozzle. A safety interlock coupled to an activating mechanism and the chamber filling mechanism prevents unwanted discharge of the injection.

Abstract: This invention provides DNA molecules which comprise 5' non-translated leader sequences derived from genes coding for heat shock proteins that enhance gene expression in plants when present in a chimeric gene. Plant cells and plants containing same are also provided herewith. Further provided is a method for enhancing gene expression in plants.