Abstract: A fertility conception system comprising a carrier adapted to receive a condom having a closed; a transfer top defining a passage onto the carrier; a cervical cap; a receptacle; and a piston moveable relative to the receptacle to transfer semen from through the passage into the cervical cap, the piston moveable by pushing down axially on the receptacle; wherein the receptacle is effectively sealed from air passage by the piston at the bottom end, and the transfer top and the condom at the top end, and a space between the transfer top and receptacle is sealed by the condom.

Abstract: Devices and methods for vaginal insertion are disclosed.

Abstract: An artificial insemination device may include a condom having a sheath and a reinforced cup that caps one end of the sheath, thereby having an inner concave surface and an outer convex surface; and a delivery handle comprising an elongate extension sized, shaped, shaped to contact the outer convex surface of the condom cup.

Abstract: A trans-femoral implant includes an anchor assembly and a balloon assembly configured to be separately delivered to an implant site within a heart. Once delivered, the anchor assembly and balloon assembly may be coupled to form an implant within the heart. The balloon anchor may include a fluid inflatable balloon that may be selectively filled via a balloon filling valve. The balloon assembly may further include a latching mechanism that may couple with a distal end of the anchor assembly, such that the length of the implant may be adjusted within the heart.

Abstract: Devices and methods for vaginal insertion are disclosed.

Abstract: A trans-femoral implant includes an anchor assembly and a balloon assembly configured to be separately delivered to an implant site within a heart. Once delivered, the anchor assembly and balloon assembly may be coupled to form an implant within the heart. The balloon anchor may include a fluid inflatable balloon that may be selectively filled via a balloon filling valve. The balloon assembly may further include a latching mechanism that may couple with a distal end of the anchor assembly, such that the length of the implant may be adjusted within the heart.

Abstract: A staple, a stapler, and an introducer are disclosed for closing a wound and for wound site management. The staple is deformable, and includes a plurality of tissue-piercing prongs which are expanded outwardly, inserted into tissue and collapsed inwardly to close the wound. The stapler includes a plurality of mechanisms to deform the staple into various positions. An introducer is provided that includes a plurality of spaced-apart wire guides for securing and centering the wound opening during a medical procedure, and during closure of the wound.

Abstract: The present invention relates to a device for delivering a flowable composition comprising cells, wherein the flowable composition is in an amount effective to treat an injured or diseased site. The device comprises a delivery device adapted for minimally-invasive delivery of the flowable composition through which the flowable composition can be passed while maintaining the effectiveness and viability of the cells of the flowable composition. The present invention further relates to a method for delivering the flowable composition comprising cells. The method comprises the steps of percutaneously inserting a delivery device adapted for minimally-invasive delivery of the flowable composition through which the flowable composition can be passed while maintaining the effectiveness and viability of the cells of the flowable composition and administering the flowable composition at, adjacent to or in the vicinity of the injured or diseased site.

Abstract: An introducer comprises a sheath, a guide rod, at least one wire stabilization guide, and a loop actuation wire for securing and centering a wound opening during a medical procedure (e.g., wherein a transluminal device is utilized) and during closure of the wound. The guide rod is sized to fit within the inside diameter of the sheath. The guide rod has at least one slot along its length for releasably holding the loop actuation wire. One or more wire stabilization guides or elongated members are coupled to the sheath. In one exemplary embodiment, the elongated members may be actuated to form a loop, so that when the sheath is approximated to a wound site, the loop portion is approximated to tissue surrounding the wound site to hold the sheath approximately centered on the wound site.

Abstract: A tissue staple that includes a pair of legs arranged generally parallel to one another connected by a pair of tabs. The tabs define an arc that extends distally from the proximal ends of the legs, and further define a slot between the tabs. The distal end of the leg may include a forked portion that defines two or more tissue piercing prongs. The location of the fork also may define a tissue stop. The legs may also include an indent that bends inwardly toward an indent formed on the other leg.

Abstract: A medical stapling system for closing a vascular puncture includes a mandrel having a flared head that is proximally retracted through a staple in order to splay the legs of the staple. The head has a plurality of channels configured to house the prongs of the staple legs prior to their expansion to prevent physical damage to the tissue and/or the staple tips and to allow the stapling system to have a low delivery profile as the staple is being delivered to the vascular puncture.

Abstract: An introducer having a sheath, a guide rod, and at least two wire stabilization guides being elongated members, at least a portion of which extend from an end of the sheath. The portions of the wire stabilization guides include a retention device formed on the portion of the wire stabilization guides that extend from the end of the sheath. The retention device is adapted to selectively expand outwardly, stabilizing the sheath relative to a wound site. The guide rod may be provided with one or more blood marking lumen, having a distal port, for identifying the depth of insertion into an artery or vein based on the presence or absence of pressurized blood in the lumen.

Abstract: A staple and stapler and introducer are disclosed for closing a wound and for wound site management. The staple is deformable, and includes a plurality of tissue-piercing prongs which are expanded outwardly, inserted into tissue and collapsed inwardly to close the wound. The stapler includes a plurality of mechanisms to deform the staple into various positions. An introducer is provided that includes a plurality of spaced-apart wire guides for securing and centering the wound opening during a medical procedure, and during closure of the wound.

Abstract: An introducer comprises a sheath, a guide rod, and at least one wire stabilization guide. The guide rod is sized to fit within the inside diameter of the sheath. The guide rod has at least one slot along its length for releasably holding the wire stabilization guide. One or more wire stabilization guides are coupled to the sheath. In one exemplary embodiment, the wire stabilization guides are inserted into a wound site and are dimensioned so as to cause an outward stretching force on the wound site. In another embodiment, the wire stabilization guides may form a loop, so that when the sheath is approximated to a wound site, the loop is approximated to tissue surrounding the wound site to hold the sheath approximately centered on the wound site. In other embodiments, the wire stabilization guides may include a retention device to hold the sheath approximate to the wound site.

Abstract: A tissue staple that includes a pair of legs arranged generally parallel to one another connected by a pair of tabs. The tabs define an arc that extends distally from the proximal ends of the legs, and further define a slot between the tabs. The distal end of the leg may include a forked portion that defines two or more tissue piercing prongs. The location of the fork also may define a tissue stop. The legs may also include an indent that bends inwardly toward an indent formed on the other leg.

Abstract: An introducer comprises a sheath, a guide rod, at least one wire stabilization guide, and a loop actuation wire for securing and centering a wound opening during a medical procedure (e.g., wherein a transluminal device is utilized) and during closure of the wound. The guide rod is sized to fit within the inside diameter of the sheath. The guide rod has at least one slot along its length for releasably holding the loop actuation wire. One or more wire stabilization guides or elongated members are coupled to the sheath. In one exemplary embodiment, the elongated members may be actuated to form a loop, so that when the sheath is approximated to a wound site, the loop portion is approximated to tissue surrounding the wound site to hold the sheath approximately centered on the wound site.

Abstract: A tissue staple that includes a pair of legs arranged generally parallel to one another connected by a pair of tabs. The tabs define an arc that extends distally from the proximal ends of the legs, and further define a slot between the tabs. The distal end of the leg may include a forked portion that defines two or more tissue piercing prongs. The location of the fork also may define a tissue stop. The legs may also include an indent that bends inwardly toward an indent formed on the other leg.

Abstract: An introducer comprises a sheath, a guide rod, at least one wire stabilization guide, and a loop actuation wire for securing and centering a wound opening during a medical procedure (e.g., wherein a transluminal device is utilized) and during closure of the wound. The guide rod is sized to fit within the inside diameter of the sheath. The guide rod has at least one slot along its length for releasably holding the loop actuation wire. One or more wire stabilization guides or elongated members are coupled to the sheath. In one exemplary embodiment, the elongated members may be actuated to form a loop, so that when the sheath is approximated to a wound site, the loop portion is approximated to tissue surrounding the wound site to hold the sheath approximately centered on the wound site.

Abstract: A pledget is provided for use with a surgical staple having a plurality of prongs. The pledget includes a central region that is configured to be retained adjacent to a wound site by the surgical staple. The pledget may promote hemostasis by stemming the flow of blood from a wound that is being closed by the staple. Additionally, the pledget may be provided including physiologically active agents that may inhibit infection, promote extraluminal clotting, and inhibit intraluminal clotting.

Abstract: An introducer comprises a sheath, a guide rod, at least one wire stabilization guide, and a loop actuation wire for locating within a wound opening during a medical procedure and during closure of the wound. The elongated members may be actuated to form a loop, or the wire stabilization guides may be adapted loop actuation wire is threaded into the slot and comprises at least a first end and a loop portion. The first end is slidably disposed through the wire stabilization guide, and the loop portion is disposed so that, when the sheath is approximated to a wound site, the loop portion is approximated to tissue surrounding the wound site to hold the sheath approximately centered on the wound site. A method for identifying the depth of insertion of a transluminal device into an artery or vein based on the presence of pressurized blood internal to the vessel and the absence of pressurized blood external to the vessel is also provided.