Abstract: The present invention relates to compositions and methods for prevention and treatment of diseases and conditions, including ocular diseases and conditions, characterized by aberrant fibrogenesis or scarring, inflammation and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against bioactive lipids and which are capable of decreasing the effective concentration of said bioactive lipid. In some embodiments, the immune-derived moiety is a monoclonal antibody that is reactive against sphingosine-1-phosphate (S1P) or lysophosphatidic acid (LPA).

Abstract: A fluid jet cutter for removing tissues from a patient's body, and in particular for performing vitrectomy surgery within the patient's eye, is provided having an elongated casing tube connected to a handle at a proximal end, a water supply tube through the casing tube interior, and an opening through the side of the casing tube adjacent a distal end. The distal end of the tube is sealed closed with a hemispherical cap. A nozzle is attached to the distal end of the water supply tube and located adjacent the proximal side of the opening in the casing tube. A vacuum is provided inside the casing tube around the water supply tube. The other end of the water supply tube is connected to a pressurized water supply adjacent the handle. The nozzle forms the pressurized water into a jet which can cut tissues. The vacuum both draws tissues into the interior of the casing tube through the opening, into the path of the water jet for cutting and/or disintegration, and aspirates the cut tissues.