Patents by Inventor Gloria ESPOSITO

Gloria ESPOSITO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Long germline DH genes and long HCDR3 antibodies
    Patent number: 11946063
    Abstract: The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: April 2, 2024
    Assignee: TRIANNI, INC.
    Inventors: Matthias Wabl, Werner Mueller, Peter Burrows, Gloria Esposito, Bao Duong
  • TRANSGENIC MAMMALS AND METHODS OF USE THEREOF
    Publication number: 20220369609
    Abstract: Transgenic mammals that express bovine-based immunoglobulins are described herein, including transgenic rodents that express bovine-based immunoglobulins for the development of bovine therapeutic antibodies.
    Type: Application
    Filed: June 30, 2020
    Publication date: November 24, 2022
    Inventors: Bao DUONG, Werner MUELLER, Peter Daniel BURROWS, Gloria ESPOSITO, Matthias WABL
  • ADAM6 KNOCKIN MICE
    Publication number: 20210059229
    Abstract: A transgenic mouse that is engineered by one or more genetic modifications that delete endogenous Adam6a and Adam6b genes in a male mouse, which mouse comprises in its genome only one exogenous Adam6 transgene, and expresses an ADAM6 protein comprising at least 90% sequence identity to SEQ ID NO:1 or SEQ ID NO:2, which Adam6 transgene is functional in a male mouse.
    Type: Application
    Filed: January 13, 2020
    Publication date: March 4, 2021
    Inventors: Gloria ESPOSITO, Matthias WABL, Werner MUELLER
  • TRANSGENIC MAMMALS AND METHODS OF USE THEREOF
    Publication number: 20210000087
    Abstract: Transgenic mammals that express canine-based immunoglobulins are described herein, including transgenic rodents that express canine-based immunoglobulins for the development of canine therapeutic antibodies.
    Type: Application
    Filed: June 30, 2020
    Publication date: January 7, 2021
    Inventors: Bao DUONG, Peter Daniel BURROWS, Werner MUELLER, Gloria ESPOSITO, Matthias WABL