Patents by Inventor Gnanaprakasam Andrew

Gnanaprakasam Andrew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Salts in the preparation of cephalosporin antibiotics
    Patent number: 7741478
    Abstract: Compounds of general formula (II), wherein R1 represents R4 represents hydrogen or —CHO group, R5 represents hydrogen or trityl, R2 represents hydrogen or methoxy group, R3 represents —CH?CH2 or and M represents a dialkyl or dicycloalkyl ethylenediamine group selected from N,N?-diisobutylethylenediamine, N,N?-dicyclohexylethylenediamine, and N,N?-dicyclopentylethylenediamine, are useful in a process to make cephalosporin antibiotics of formula (I) wherein R represents hydrogen or pharmaceutically acceptable esters or alkali metals salts.
    Type: Grant
    Filed: July 4, 2005
    Date of Patent: June 22, 2010
    Assignee: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Udayampalayam Palanisamy Senthilkumar, Venu Sanjeevi Lakshmipathi, Gnanaprakasam Andrew, Ramasubbu Chandrasekaran, Dindigala Nagender Rao, Gaddam Om Reddy
  • Salts in the Preparation of Cephalosporin Antibiodies
    Publication number: 20080306256
    Abstract: The present invention relates to an improved process for the preparation of cephalosporin antibiotics of formula (I). The present invention also provides new salts of compound of formula (II) and a process for the preparation of these new salts, where n=0.5 to 2. The present invention also provides a process for the preparation of compound of formula (I) using the new salts of formula (II).
    Type: Application
    Filed: July 4, 2005
    Publication date: December 11, 2008
    Applicant: Orchid Chemicals & Pharmaceuticals Limited
    Inventors: Udayampalayam P. Senthilkumar, Venu S. Lakshmipathi, Gnanaprakasam Andrew, Ramasubbu Chandrasekaran, Dindigala Nagender Rao, Gaddam Om Reddy
  • Process for preparation of penam derivatives from cepham derivatives
    Patent number: 6936711
    Abstract: The present invention relates to a process for preparing 2?-methyl-2?-substituted methyl penam derivatives from cepham derivatives, more particularly the present invention provides a novel process for preparing 2?-heterocyclyl methyl penam derivatives of the formula (I) by reacting a cepham compound with a heterocylic amine to form an intermediate compound, and oxidizing the intermediate compound to produce the 2?-heterocyclyl methyl penam derivatives of the formula (I), wherein R1 represents carboxylic acid protecting group; R2 and R3 may be same or different and independently represent hydrogen, halogen, NH2, acylamino, phthalimido with a proviso that both R2 and R3 are not NH2, acylamino, phthalimido; Het represents a 5 or 6 membered nitrogen containing heterocycle ring system having one or more heteroatoms selected from O, S, or N.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: August 30, 2005
    Assignee: Orchid Chemicals and Pharmaceuticals Limited
    Inventors: Pandurang Balwant Deshpande, Senthil Kumar Udayampalayam Palanisamy, Gnanaprakasam Andrew
  • Method for the conversion of a Z-isomer into E-isomer
    Patent number: 6844471
    Abstract: A method of converting (Z)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (II) to (E)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (I) wherein R1, R2, and R3 are the same or different and independently represent (C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkyl, (C1-C4)alkoxy(C1-C4)alkoxy(C1-C4)alkyl, allyl, vinyl, silyl, formyl, acyl, aryl(C1-C4)alkyl or substituted aryl(C1-C4)alkyl group. The present invention also provides a process for the conversion of (E)-(3,5-disubstituted phenyl-2-(4-substituted phenyl)ethene of general formula (I) to E-resveratrol of formula (III).
    Type: Grant
    Filed: December 5, 2002
    Date of Patent: January 18, 2005
    Assignee: Orchid Chemicals and Pharmaceuticals Limited
    Inventors: Pandurang Balwant Deshpande, Senthil Kumar Udayampalayam Palanisamy, Gnanaprakasam Andrew
  • Method for the conversion of a Z-isomer into E-isomer
    Publication number: 20040015020
    Abstract: A method of converting (Z)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (II) to (E)-1-(3,5-disubstituted phenyl)-2-(4-substituted phenyl)ethene of general formula (I) 1
    Type: Application
    Filed: December 5, 2002
    Publication date: January 22, 2004
    Applicant: ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED
    Inventors: Pandurang Balwant Deshpande, Senthil Kumar Udayampalayam Palanisamy, Gnanaprakasam Andrew
  • Process for preparation of penam derivatives from cepham derivatives
    Publication number: 20030232983
    Abstract: The present invention relates to a process for preparing 2&agr;-methyl-2&bgr;-substituted methyl penam derivatives from cepham derivatives, more particularly the present invention provides a novel process for preparing 2&bgr;-heterocyclyl methyl penam derivatives of the formula (I) 1
    Type: Application
    Filed: December 4, 2002
    Publication date: December 18, 2003
    Applicant: Orchid Chemicals and Pharmaceuticals Limited
    Inventors: Pandurang Balwant Deshpande, Senthil Kumar Udayampalayam Palanisamy, Gnanaprakasam Andrew
  • Stereoselective route to produce tris-O-substituted-(E)-1-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethene, an intermediate in the synthesis of trans-resveratrol
    Patent number: 6552213
    Abstract: The present invention relates to a new stereoselective method for the preparation of tris-O-substituted-(E)-1-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)ethene derivative of the formula (I) which is a key intermediate in the synthesis of trans-resveratrol (I, R2=R2=R3=H). The invention also provides a method for the exclusive synthesis of trans-isomer of compounds of formula (I) without any contamination of cis-isomer.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: April 22, 2003
    Assignee: Orchid Chemicals & Pharmaceuticals Limited, India
    Inventors: Pandurang Balwant Deshpande, Udayampalayam Palanisamy Senthilkumar, Gnanaprakasam Andrew