Abstract: The disclosure provides a pharmaceutical composition containing an anti-IgE antibody that suppresses the production of allergen-specific IgE antibodies and methods of use thereof.

Abstract: This saddle-riding type vehicle includes: a transmission that includes a clutch operated by an operation of a slave cylinder; an oil pressure actuator that includes a master cylinder which generates an oil pressure on an operation oil; an oil pressure valve unit that controls transmission of the oil pressure generated by the master cylinder to the slave cylinder; a master-side connection pipe arrangement that connects the master cylinder to the oil pressure valve unit; and a slave-side connection pipe arrangement that connects the oil pressure valve unit to the slave cylinder, wherein the slave cylinder and the oil pressure valve unit are arranged on one side part in a vehicle width direction of the saddle-riding type vehicle, and the oil pressure actuator is arranged on another side part in the vehicle width direction of the saddle-riding type vehicle.

Abstract: This transmission device includes a mode changeover switch (59) on which a mode changeover operation between a manual mode (M2) and an automated mode (M1) is externally performed, other operation unit (80) on which a predetermined shift operation is externally performed separately from the mode changeover switch (59), and a control unit (60) configured to control a mode changeover between the manual mode (M2) and the automated mode (M1). The control unit (60) executes the mode changeover between the manual mode (M2) and the automated mode (M1) on the basis of the mode changeover operation on the mode changeover switch (59). When the shift operation on the other operation unit (80) has been performed, the control unit (60) executes the mode changeover between the manual mode (M2) and the automated mode (M1).

Abstract: A clutch locking mechanism is a clutch locking mechanism (80) mounted in a saddle type vehicle (1) and includes a clutch (26) which enters an engaged state where power can be transmitted when an actuator (28) is operated and returns to a disengaged state where power cannot be transmitted when the actuator (28) is not operated, and a locking mechanism (100) having an operator (101) which is able to bring the clutch (26) into the engaged state separately from an operation of the actuator (28).

Abstract: This clutch control device includes an engine (13), a transmission (21), a clutch device (26) configured to connect and disconnect motive power transmission between the engine (13) and the transmission (21), a clutch actuator (50) configured to drive the clutch device (26) and change a clutch capacity, a clutch operating element (4b) configured to enable the clutch device (26) to be manually operated, and a control unit (60) configured to calculate a target value (Pt) of a control parameter (Ps) of the clutch capacity in accordance with an amount of operation on the clutch operating element (4b).

Abstract: A reactive force generation device (130) of clutch-by-wire system is a reactive force generation device which generates a reactive force on a clutch lever (51), and includes a piston structure in which an air bleeding hole (139) is provided, and a contact member (133) which is in contact with the clutch lever (51) and in which the air bleeding hole 139 is formed.

Abstract: A vehicle control device includes an information acquisition unit that acquires road surface condition information indicative of a road surface condition determined on the basis of sound data obtained by performing sound source separation with respect to a sound acquired by a microphone array, a storage unit in which there is stored control content in accordance with the road surface condition, and a control unit which controls a drive unit provided on a vehicle, on the basis of the control content in accordance with the road surface condition indicated by the road surface condition information.

Abstract: This transmission device includes a mode changeover switch (59) on which a mode changeover operation between a manual mode (M2) and an automated mode (M1) is externally performed, other operation unit (80) on which a predetermined shift operation is externally performed separately from the mode changeover switch (59), and a control unit (60) configured to control a mode changeover between the manual mode (M2) and the automated mode (M1). The control unit (60) executes the mode changeover between the manual mode (M2) and the automated mode (M1) on the basis of the mode changeover operation on the mode changeover switch (59). When the shift operation on the other operation unit (80) has been performed, the control unit (60) executes the mode changeover between the manual mode (M2) and the automated mode (M1).

Abstract: This saddle-riding type vehicle includes: a transmission that includes a clutch operated by an operation of a slave cylinder; an oil pressure actuator that includes a master cylinder which generates an oil pressure on an operation oil; an oil pressure valve unit that controls transmission of the oil pressure generated by the master cylinder to the slave cylinder; a master-side connection pipe arrangement that connects the master cylinder to the oil pressure valve unit; and a slave-side connection pipe arrangement that connects the oil pressure valve unit to the slave cylinder, wherein the slave cylinder and the oil pressure valve unit are arranged on one side part in a vehicle width direction of the saddle-riding type vehicle, and the oil pressure actuator is arranged on another side part in the vehicle width direction of the saddle-riding type vehicle.

Abstract: A clutch-by-wire system measures a position of a clutch lever (51) when predetermined learning permission conditions are satisfied and performs updating processing as a release position of the clutch lever (51) of updating a position which is previously stored. The clutch-by-wire system (51) repeatedly performs the updating processing after power is supplied.

Abstract: A clutch locking mechanism is a clutch locking mechanism (80) mounted in a saddle type vehicle (1) and includes a clutch (26) which enters an engaged state where power can be transmitted when an actuator (28) is operated and returns to a disengaged state where power cannot be transmitted when the actuator (28) is not operated, and a locking mechanism (100) having an operator (101) which is able to bring the clutch (26) into the engaged state separately from an operation of the actuator (28).

Abstract: A clutch lever device (50) includes a clutch lever (60) rotatably provided and operated by a user, an elastic deformation portion (81) which is a generation source of an operation reaction force of the clutch lever (60), and a rotary body (91) which is configured to rotate around a first axis (O) in accordance with rotation of the clutch lever (60) and elastically deform the elastic deformation portion (81). The rotary body (91) is configured to change an elastic deformation amount of the elastic deformation portion (81) per unit rotation angle of the clutch lever (60) in accordance with a rotation angle from a pre-operation position of the clutch lever (60).

Abstract: This clutch control device includes an engine (13), a transmission gear (21), a clutch device (26), a clutch actuator (50), a control unit (60), a control parameter sensor (58), a clutch operator (4b), and a clutch operation amount sensor (4c), wherein the control unit (60) is configured to enable intervention of a manual clutch operation according to the clutch operator (4b) during automatic control of the clutch device (26) according to the clutch actuator (50), and the control unit (60) is configured to set a control target value of a clutch capacity to a connection preparation target value (Py) acquired by causing an operation target value (Pv) corresponding to an amount of operation of the clutch operator (4b) to approach a disconnection determination value (Pz) in a case in which a control parameter detected by the control parameter sensor (58) reaches the disconnection determination value (Pz) set in advance at a time of performing a clutch disconnection operation through intervention of the manual clu

Abstract: A reactive force generation device (130) of clutch-by-wire system is a reactive force generation device which generates a reactive force on a clutch lever (51), and includes a piston structure in which an air bleeding hole (139) is provided, and a contact member (133) which is in contact with the clutch lever (51) and in which the air bleeding hole 139 is formed.

Abstract: This clutch control device includes an engine (13), a transmission gear (21), a clutch device (26), a clutch actuator (50), a control unit (60), a clutch operator (4b), and a clutch operation amount sensor (4c), wherein the control unit (60) is configured to enable intervention of a manual clutch operation according to the clutch operator (4b) during automatic control of the clutch device (26) according to the clutch actuator (50), and the control unit (60) is configured to set a control target value of a clutch capacity to a connection lower limit target value (Px) acquired by changing an operation target value (Pv) corresponding to an amount of operation of the clutch operator (4b) to a clutch disconnection side in a case in which the amount of operation of the clutch operator (4b) based on an output value of the clutch operation amount sensor (4c) reaches a predetermined value (?2) set in advance at a time of performing a clutch disconnection operation through the intervention of the manual clutch operatio

Abstract: This clutch control device includes an engine (13), a transmission (21), a clutch device (26) configured to connect and disconnect motive power transmission between the engine (13) and the transmission (21), a clutch actuator (50) configured to drive the clutch device (26) and change a clutch capacity, a clutch operating element (4b) configured to enable the clutch device (26) to be manually operated, and a control unit (60) configured to calculate a target value (Pt) of a control parameter (Ps) of the clutch capacity in accordance with an amount of operation on the clutch operating element (4b).

Abstract: A clutch lever device (50) includes a clutch lever (60) rotatably provided and operated by a user, an elastic deformation portion (81) which is a generation source of an operation reaction force of the clutch lever (60), and a rotary body (91) which is configured to rotate around a first axis (O) in accordance with rotation of the clutch lever (60) and elastically deform the elastic deformation portion (81). The rotary body (91) is configured to change an elastic deformation amount of the elastic deformation portion (81) per unit rotation angle of the clutch lever (60) in accordance with a rotation angle from a pre-operation position of the clutch lever (60).

Abstract: This clutch control device includes an engine (13), a transmission gear (21), a clutch device (26), a clutch actuator (50), a control unit (60), a clutch operator (4b), and a clutch operation amount sensor (4c), wherein the control unit (60) is configured to enable intervention of a manual clutch operation according to the clutch operator (4b) during automatic control of the clutch device (26) according to the clutch actuator (50), and the control unit (60) is configured to set a control target value of a clutch capacity to a connection lower limit target value (Px) acquired by changing an operation target value (Pv) corresponding to an amount of operation of the clutch operator (4b) to a clutch disconnection side in a case in which the amount of operation of the clutch operator (4b) based on an output value of the clutch operation amount sensor (4c) reaches a predetermined value (?2) set in advance at a time of performing a clutch disconnection operation through the intervention of the manual clutch operatio

Abstract: A clutch control device includes an engine, a gearbox, a clutch device configured to disconnect and connect power transmission between the engine and the gearbox, a clutch actuator configured to drive the clutch device and vary a clutch capacity, an engine rotational number sensor configured to detect an engine rotational number, a throttle opening angle sensor configured to detect a throttle opening angle, and a controller configured to calculate a control target value of the clutch capacity, wherein the controller calculates an estimated engine torque and causes the clutch device to change a slip clutch capacity according to the estimated engine torque.

Abstract: A clutch control device includes an ECU that controls a clutch actuator, the ECU sets a control target value of the clutch capacity according to the operation amount detected by the clutch operation amount sensor, and executes feedback control so that the control parameter which is detected by the control parameter sensor approaches the control target value, and changes a method of the feedback control when the control parameter reaches a predetermined control state change determination value during the feedback control.