Patents by Inventor Gonghua Pan

Gonghua Pan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AS C5AR INHIBITORS
    Publication number: 20240043439
    Abstract: Disclosed generally relates to C5a receptor inhibitors, compositions thereof, methods of use thereof, and methods of preparation thereof.
    Type: Application
    Filed: August 6, 2021
    Publication date: February 8, 2024
    Applicant: Kira Pharmaceuticals (Suzhou) Ltd.
    Inventors: Gonghua PAN, Xihua ZHU, Yingjie ZHU
  • Pyrimidine derivatives for the treatment of abnormal cell growth
    Patent number: 7820648
    Abstract: The present invention relates to a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein Ar is a group of formula and R1, R2, R13, A, K, M, L1, L2, X, Y1, Y2, Q, salt thereof, wherein R1, R2, R13, A, K, L1, L2, W, X, Z1, Z2, Y1, Y2, Z1, Z2, M, Q, W, X, m, p and q are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: October 26, 2010
    Assignees: Pfizer Inc, Pfizer Products Inc
    Inventors: Samit Kumar Bhattacharya, Michael Joseph Luzzio, Donn Gregory Wishka, Gonghua Pan, Arthur Douglas Brosius, Joel Thomas Arcari, James Alfred Southers, Jr., Kendra Louise Nelson, Jun Xiao
  • HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS
    Publication number: 20090281073
    Abstract: This invention relates to compounds of Formula (I), and to pharmaceutically acceptable salts and solvates thereof, wherein Z, W, X, Y, V, R1, R2, and R3 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of Formula (I) and to pharmaceutical compositions for treating such disorders which contain the compounds of Formula (I). The invention also relates to methods of preparing the compounds of Formula (I).
    Type: Application
    Filed: December 15, 2005
    Publication date: November 12, 2009
    Inventors: Samit Kumar Bhattacharya, Donna G. Wishka, Gonghua Pan
  • BICYCLIC HETEROAROMATIC DERIVATIVES USEFUL AS ANTICANCER AGENTS
    Publication number: 20090111805
    Abstract: The invention relates to compounds of the formula I: and to pharmaceutically acceptable salts and solvates thereof, wherein X, Z, V, W, R4, R5, R6, R7, and ring B are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula I and to pharmaceutical compositions for treating such disorders which contain the compounds of formula I. The invention also relates to methods of preparing the compounds of formula I.
    Type: Application
    Filed: February 15, 2006
    Publication date: April 30, 2009
    Inventors: Joel Morris, Blaise Scott Lippa, Gonghua Pan, Goss Stryker Kauffman, Chao Li
  • PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
    Publication number: 20080234303
    Abstract: The present invention relates to a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein Ar is a group of formula and R1, R2, R13, A, K, M, L1, L2, X, Y1, Y2, Q, salt thereof, wherein R1, R2, R13, A, K, L1, L2, W, X, Z1, Z2, Y1, Y2, Z1, Z2, M, Q, W, X, m, p and q are as defined herein. Such novel pyrimidine derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: December 20, 2006
    Publication date: September 25, 2008
    Inventors: Samit Bhattacharya, Michael Luzzio, Donn Wishka, Gonghua Pan, Arthur Brosius, Joel Arcari, James Southers, Kendra Nelson, Jun Xiao
  • Bradykinin B1 receptor antagonists
    Patent number: 6919347
    Abstract: Bradykinin B1-receptor antagonists of formula are disclosed. The compounds are useful for treating diseases associated with inappropriate bradykinin receptor activity, such as diabetic vasculopathy, inflammation, pain, hyperalgesia, asthma, rhinitis, septic shock, atherosclerosis and multiple sclerosis. Pyrimidines, triazines, and anilines in which Q is imidazolyl or pyrrolyl are particularly preferred.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: July 19, 2005
    Assignee: Pharmacopeia Drug Discovery, Inc.
    Inventors: Michael H. J. Ohlmeyer, John J. Baldwin, Roland E. Dolle, III, Vidyadhar Paradkar, Jorge Gabriel Quintero, Gonghua Pan
  • N-heterocyclic derivatives as NOS inhibitors
    Patent number: 6887865
    Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: May 3, 2005
    Assignees: Berlex Laboratories, Inc., Pharmacopeia Drug Discovery, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, III, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • N-heterocyclic derivatives as NOS inhibitors
    Patent number: 6864368
    Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: March 8, 2005
    Assignees: Berlax Laboratories, Inc., Pharmacopeia Drug Discovery, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, III, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • N-heterocyclic derivatives as NOS inhibitors
    Patent number: 6864263
    Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: March 8, 2005
    Assignees: Berlex Laboratories, Inc., Pharmacopeia Drug Discovery, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, III, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • N-heterocyclic derivatives as NOS inhibitors
    Patent number: 6849739
    Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: February 1, 2005
    Assignees: Berlex Laboratories, Inc., Pharmacopeia Drug Discovery, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, III, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • N-heterocyclic derivatives as NOS inhibitors
    Patent number: 6846829
    Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: January 25, 2005
    Assignees: Berlex Laboratories, Inc., Pharmacopeia Drug Discovery, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, III, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • N-heterocyclic derivatives as NOS inhibitors
    Patent number: 6841674
    Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: January 11, 2005
    Assignees: Berlex Laboratories, Inc., Pharmacopeia Drug Discovery, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, III, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • N-heterocyclic derivatives as nos inhibitors
    Patent number: 6841673
    Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: January 11, 2005
    Assignees: Berlex Laboratories, Inc., Pharmacopeia, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, III, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • N-heterocyclic derivatives as NOS inhibitors
    Patent number: 6747031
    Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: June 8, 2004
    Assignees: Berlex Laboratories, Inc., Pharmacopeia, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, III, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • N-heterocyclic derivatives as NOS inhibitors
    Patent number: 6670473
    Abstract: N-Heterocyclic derivatives of the formula (I): are described herein, as well as other N-heterocycles, as inhibitors of nitric oxide synthase. Pharmaceutical compositions containing these compounds, methods of using these compounds as inhibitors of nitric oxide synthase and processes for synthesizing these compounds are also described herein.
    Type: Grant
    Filed: April 12, 2002
    Date of Patent: December 30, 2003
    Assignees: Berlex Laboratories, Inc., Pharmacopeia, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, III, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • Bradykin B1receptor antagonists
    Publication number: 20030229092
    Abstract: Bradykinin B1-receptor antagonists of formula 1
    Type: Application
    Filed: January 14, 2002
    Publication date: December 11, 2003
    Applicant: PHARMACOPEIA, INC.
    Inventors: Michael H.J. Ohlmeyer, John G. Baldwin, Roland E. Dolle, Vidyadhar Paradkar, Jorge Gabriel Quintero, Gonghua Pan
  • N-heterocyclic derivatives as NOS inhibitors
    Publication number: 20030092678
    Abstract: N-Heterocyclic derivatives of the formula (I): 1
    Type: Application
    Filed: April 12, 2002
    Publication date: May 15, 2003
    Applicant: Berlex Laboratories, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H.J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • N-heterocyclic derivatives as NOS inhibitors
    Publication number: 20030083332
    Abstract: N-Heterocyclic derivatives of the formula (I): 1
    Type: Application
    Filed: April 12, 2002
    Publication date: May 1, 2003
    Applicant: Berlex Laboratories, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • N-heterocyclic derivatives as NOS inhibitors
    Publication number: 20030078265
    Abstract: N-Heterocyclic derivatives of the formula (I): 1
    Type: Application
    Filed: April 12, 2002
    Publication date: April 24, 2003
    Applicant: Berlex Laboratories, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H. J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao
  • N-heterocyclic derivatives as NOS inhibitors
    Publication number: 20030073669
    Abstract: N-Heterocyclic derivatives of the formula (I): 1
    Type: Application
    Filed: April 12, 2002
    Publication date: April 17, 2003
    Applicant: Berlex Laboratories, Inc.
    Inventors: Damian O. Arnaiz, John J. Baldwin, David D. Davey, James J. Devlin, Roland Ellwood Dolle, Shawn David Erickson, Kirk McMillan, Michael M. Morrissey, Michael H.J. Ohlmeyer, Gonghua Pan, Vidyadhar Madhav Paradkar, John Parkinson, Gary B. Phillips, Bin Ye, Zuchun Zhao