Patents by Inventor Gopalan Soman

Gopalan Soman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stabilization of helicobacter urease
    Patent number: 6709851
    Abstract: The invention provides methods for stabilizing recombinant Helicobacter urease by genetically modifying a urease amino acid. The stabilized urease is prevented from the molecular aggregation or activation (e.g., in vitro activation) characteristic of untreated urease.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: March 23, 2004
    Assignee: OraVax-Merieux Co.
    Inventors: Gopalan Soman, William D. Thomas, Jr., Thomas P. Monath
  • Method for preventing the activation of inactive, recombinant Helicobacter pylori apourease
    Patent number: 5985631
    Abstract: A method for preventing the activation of inactive, recombinant Helicobacter pylori apourease is presented. The method comprises contacting the apourease with a compound that modifies a sulfhydryl or lysyl residue of the urease. The covalently modified apourease is prevented from molecular aggregation.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: November 16, 1999
    Assignee: OraVax-Merieux Co.
    Inventors: Gopalan Soman, William D. Thomas, Jr., Thomas P. Monath
  • Multimeric, recombinant urease vaccine
    Patent number: 5837240
    Abstract: Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: November 17, 1998
    Assignee: OraVax-Merieux Co.
    Inventors: Cynthia K. Lee, Thomas P. Monath, Samuel K. Ackerman, William D. Thomas, Gopalan Soman, Harold Kleanthous, Richard A. Weltzin, Jacques Pappo, Thomas Ermak, Farshad Guirakhoo, Hitesh Bhagat, Ilene Sussman