Abstract: The invention concerns a vehicle guided on a railway track comprising a chassis and at least one wheel assembly interconnected to the chassis and a method for steering said vehicle. The wheel assembly comprises a cross-member having a first end to which a first hub is interconnected by a first steering joint and a second end to which a second hub is interconnected by a second steering joint. A first wheel is attached to the first hub rotatable around a first rotation axis and a second wheel is attached to the second hub rotatable around a second rotation axis. A first sensor determines the lateral position of the first sensor with respect to the rail. The first sensor is attached to the first hub and is, with respect to a direction of travel arranged in front of the supporting area of the first wheel in a horizontal direction spaced a distance A1 apart.

Abstract: The invention provides novel coumarin derivatives as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

Abstract: The present invention relates to methods for detection of nucleotide polymerase activity and methods of detecting compounds that modulate nucleotide polymerase activity, by detecting product formation of the nucleotide polymerase to be tested based on determination of close proximity of two labeled nucleotide probes able to bind the product of the nucleotide polymerase. It is preferred that proximity dependent energy transfer, such as forster resonance energy transfer, between said labeled nucleotide probes is determined. The invention further provides kits comprising components for carrying out the inventive methods for detection of nucleotide polymerase activity.

Abstract: The invention provides novel coumarin derivatives as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

Abstract: A demolding device for use in an imprint machine, in which a foil is intermittently passed in a feed direction over a press region where a stamp is pressed against the foil for imprinting a surface pattern. The demolding device includes a carrier, a pressing roller mounted in the carrier, and a demolding roller mounted parallel to the pressing roller in the carrier, wherein the carrier is configured to slide over the press region against the feed direction while rolling the foil under the pressing roller and over the demolding roller for detaching the foil from the stamp after imprinting of the pattern.

Abstract: The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

Abstract: The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

Abstract: The invention concerns a vehicle guided on a railway track comprising a chassis and at least one wheel assembly interconnected to the chassis and a method for steering said vehicle. The wheel assembly comprises a cross-member having a first end to which a first hub is interconnected by a first steering joint and a second end to which a second hub is interconnected by a second steering joint. A first wheel is attached to the first hub rotatable around a first rotation axis and a second wheel is attached to the second hub rotatable around a second rotation axis. A first sensor determines the lateral position of the first sensor with respect to the rail. The first sensor is attached to the first hub and is, with respect to a direction of travel, arranged in front of the supporting area of the first wheel in a horizontal direction spaced a distance A1 apart.

Abstract: The present invention relates to methods for detection of nucleotide polymerase activity and methods of detecting compounds that modulate nucleotide polymerase activity, by detecting product formation of the nucleotide polymerase to be tested based on determination of close proximity of two labeled nucleotide probes able to bind the product of the nucleotide polymerase. It is preferred that proximity dependent energy transfer, such as forster resonance energy transfer, between said labeled nucleotide probes is determined. The invention further provides kits comprising components for carrying out the inventive methods for detection of nucleotide polymerase activity.

Abstract: A demolding device for use in an imprint machine, in which machine a foil is intermittently passed in a feed direction over a press region where a stamp is pressed against the foil for imprinting a surface pattern. The demolding device includes a carrier, a pressing roller mounted in the carrier, and a demolding roller mounted parallel to the pressing roller in the carrier, wherein the carrier is configured to slide over the press region against the feed direction while rolling the foil under the pressing roller and over the demolding roller for detaching the foil from the stamp after imprinting of the pattern.

Abstract: A clearing system for clearing transactions associated with a plurality of accounts, the clearing system being configured to organise the plurality of accounts in at least three independent structures comprising a member structure, a user access structure and a risk calculation structure. The clearing system may further be configured to organise a plurality of members clearing through the clearing system and a plurality of users using the clearing system in a tree structure independent from said three independent structures.

Abstract: The invention relates to a transgenic mouse model with deficient respiratory chain function in dopamine (DA) neurons. By suppressing or deleting the mitochondrial transcription factor A (Tfam) in DA neurons, a mouse model is obtained, which reproduces key pathophysiological features of Parkinson's disease (PD), i.e., slow progressive loss of DA terminals in striatum and loss of DA neurons in substantia nigra pars compacta; alpha-synuclein immunoreactivity including intracellular inclusions similar to Lewy bodies in affected areas prior to and during cell loss; progressive movement disorder associated with abnormal gait, tremor and rigid limbs. The mouse model can be used to develop pharmacological, gene therapy or cell therapy treatments for PD.

Abstract: In a method and a system for executing automated matching of financial instruments, an order book of the automated trading system in which orders are placed is interconnected with a position-keeping system or module. This is done in a way such that a controlling unit connected to both the order book and the position-keeping system can cancel orders in the order book, if, when an order is traded, insufficient collateral remains for any remaining order in the order book to be covered if traded. The methods and systems can advantageously be used in automated trading systems having a central counterpart.

Abstract: The invention relates to a transgenic mouse model with deficient respiratory chain function in dopamine (DA) neurons. By suppressing or deleting the mitochondrial transcription factor A (Tfam) in DA neurons, a mouse model is obtained, which reproduces key pathophysiological features of Parkinson's disease (PD), i.e., slow progressive loss of DA terminals in striatum and loss of DA neurons in substantia nigra pars compacta; alpha-synuclein immunoreactivity including intracellular inclusions similar to Lewy bodies in affected areas prior to and during cell loss; progressive movement disorder associated with abnormal gait, tremor and rigid limbs. The mouse model can be used to develop pharmacological, gene therapy or cell therapy treatments for PD.

Abstract: A microfluidic device having a plurality of microchannel structures and a memory. The memory may be writeable with restriction for unauthorized access. Yet further, the memory can be information about positions of non-redundant or redundant microchannel, information relating to positions for interfacing the microchannel structures with the macroworld, or supplemental information relating to process protocols that are allowed for the microchannel structures of the device.

Abstract: Apoptosis can be induced in a mammalian cell by administering a substance capable of impairing mammalian mitochondrial DNA gene expression to said cell in such an amount that apoptosis is induced. Certain antisense nucleic acid molecules specifically binding to nucleic acid molecules encoding proteins affecting mitochondrial gene expression are preferably used. The invention also provides novel such antisense nucleic acid molecules and pharmaceutical compositions containing the novel compounds. The invention also describes the use of an in vitro assay consisting of TFAM, TFB1M, TFB2M, mtRNAP and a mtDNA promoter fragment, to identify substances that inhibit or stimulate mtDNA transcription.

Abstract: A motor vehicle designed to carry a foldable warning triangle that can be removed from the vehicle. The vehicle has an opening defined by a boundary edge and covered by a hatch such as a trunk or hood. The hatch is arranged so that it can be moved between a closed position and an open position. The fold-up warning triangle is secured in an edge portion of the hatch that bears against the boundary edge of the opening when the hatch is in the closed position. A warning surface of the warning triangle is visible to other traffic when the hatch is opened. In a preferred embodiment, the fold-up warning triangle is releasably placed in a recess in the edge portion of the hatch. The recess has a wall interrupted by at least one hole through which the warning surface is visible to other traffic when the hatch is open.

Abstract: A motor vehicle arrangement having a control device for controlling the vehicle. The control device is at least adjustable in the vertical direction. The control device has a parking position in which the vehicle cannot be driven and there is no operative connection for starting, accelerating or braking the vehicle etc. from the operating controls of the vehicle. The control device is releasable from the parking position to a driving position using an authorization verification element which adjusts the driving position. In the driving position, an operative connection is established between the operating control elements of the vehicle and corresponding actuating elements.

Abstract: A microfluidic device having a plurality of microchannel structures and a memory. The memory may be writeable with restriction for unauthorized access. Yet further, the memory can be information about positions of non-redundant or redundant microchannel, information relating to positions for interfacing the microchannel structures with the macroworld, or supplemental information relating to process protocols that are allowed for the microchannel structures of the device.

Abstract: The present invention relates to a vehicle seating arrangement having a number of seats. The seats are arranged so that they can be moved between different mutual positions along at least two parallel rails that extend in the longitudinal direction of the vehicle in the vehicle floor. Each of the seats have a backrest part and a seat part, and are slidably attached to the rails by means of coupling members. The seats can be locked by way of the coupling members in a number of positions along the rails. The seat part of the seats is pivotably mounted in relation to the backrest part in such a way that it can assume a first, folded-down position and a second position wherein it is folded up against the backrest part. At least one rail extends essentially in the transverse direction of the vehicle.