Patents by Inventor Gordon A. Porter
Gordon A. Porter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20170267758Abstract: Binding agents that modulate the immune response are disclosed. The binding agents may include antibodies, soluble receptors, and/or polypeptides. Also disclosed are methods of using the binding agents for the treatment of diseases such as cancer.Type: ApplicationFiled: May 13, 2015Publication date: September 21, 2017Applicant: ONCOMED PHARMACEUTICALS, INC.Inventors: Austin L. GURNEY, Ming-hong XIE, James Gordon PORTER
-
Patent number: 7179790Abstract: Peptides comprising the effective portion of human brain natriuretic peptide are provided in pharmaceutical compositions and methods to effect vasodilation and/or natriuresis.Type: GrantFiled: September 23, 2005Date of Patent: February 20, 2007Assignee: Scios, Inc.Inventors: J. Jeffrey Seilhamer, John A. Lewicki, Robert M. Scarborough, J. Gordon Porter
-
Patent number: 6974861Abstract: The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically.Type: GrantFiled: March 27, 2003Date of Patent: December 13, 2005Assignee: Scios, Inc.Inventors: J. Jeffrey Seilhamer, John Lewicki, Robert M. Scarborough, J. Gordon Porter
-
Patent number: 6897030Abstract: Immunoassays and antibodies useful in conducting them for human and canine brain natriuretic peptide are described.Type: GrantFiled: July 9, 2001Date of Patent: May 24, 2005Assignee: Scios, Inc.Inventors: J. Jeffrey Seilhamer, John Lewicki, Robert M. Scarborough, J. Gordon Porter
-
Publication number: 20040002458Abstract: The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically.Type: ApplicationFiled: March 27, 2003Publication date: January 1, 2004Inventors: J. Jeffrey Seilhamer, John Lewicki, Robert M. Scarborough, J. Gordon Porter
-
Publication number: 20030194721Abstract: The invention relates to isolated polynucleotides, purified polypeptides, and compositions comprising pluralities of polynucleotides that are differentially expressed when foam cells are treated with oxidized low-density lipoprotein and LPS as associated with atherosclerosis. The invention also presents the use of the polynucleotides as elements on a substrate and provides methods for using the polynucleotides and polypeptides.Type: ApplicationFiled: September 18, 2002Publication date: October 16, 2003Applicant: Incyte Genomics, Inc.Inventors: Thomas Mikita, Dov Shiffman, J. Gordon Porter, Matthew R. Kaser
-
Publication number: 20030165924Abstract: The present invention relates to purified polynucleotides and compositions comprising pluralities of polynucleotides that are differentially expressed during foam cell development and are associated with atherosclerosis. The present invention presents the use of the compositions as elements on a substrate, and provides methods for using the compositions and polynucleotides.Type: ApplicationFiled: October 4, 2002Publication date: September 4, 2003Inventors: Dov Shiffman, Roland Somogyi, Richard Lawn, Jeffrey J. Seilhamer, J. Gordon Porter, Thomas Mikita, Julie Tai
-
Patent number: 6586396Abstract: The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically.Type: GrantFiled: April 7, 1999Date of Patent: July 1, 2003Assignee: Scios, Inc.Inventors: J. Jeffrey Seilhamer, John Lewicki, Robert M. Scarborough, J. Gordon Porter
-
Publication number: 20030109430Abstract: The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically.Type: ApplicationFiled: July 9, 2001Publication date: June 12, 2003Inventors: J. Jeffrey Seilhamer, John Lewicki, Robert M. Scarborough, J. Gordon Porter
-
Patent number: 5948761Abstract: Peptides of the formula R.sup.1 -Cys-Phe-Gly-Arg-Arg-Leu-Asp-Arg-Ile-Gly-Ser-Leu-Ser-Gly-Leu-Gly-Cys-R.sup .2wherein R.sup.1 is selected from the group consisting of:(H);Gly-;Ser-Gly-;Lys-Ser-Gly-;His-Lys-Ser-Gly-;Met-His-Lys-Ser-Gly-;Thr-Met-His-Lys-Ser-Gly-;Lys-Thr-Met-His-Lys-Ser-Gly-;Pro-Lys-Thr-Met-His-Lys-Ser-Gly-;Ser-Pro-Lys-Thr-Met-His-Lys-Ser-Gly-;or is the amino acid sequence of the dog prepro sequence upstream of position 100 shown in FIG. 8 herein or a C-terminal portion thereof;R.sup.2 is (OH), NH.sub.2, or NR.sub.2 wherein each R is independently H or lower alkyl (1-4C) or isAsn;Asn-Val;Asn-Val-Leu;Asn-Val-Leu-Arg;Asn-Val-Leu-Arg-Lys;Asn-Val-Leu-Arg-Lys-Tyr;or the amides thereof are useful in treating conditions characterized by high levels of extracellular fluid.Type: GrantFiled: May 5, 1997Date of Patent: September 7, 1999Assignee: Scios, Inc.Inventors: J. Jeffrey Seilhamer, John Lewicki, Robert M. Scarborough, J. Gordon Porter
-
Patent number: 5674710Abstract: The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically.Type: GrantFiled: February 8, 1990Date of Patent: October 7, 1997Assignee: Scios, Inc.Inventors: J. Jeffrey Seilhamer, John Lewicki, Robert M. Scarborough, J. Gordon Porter
-
Patent number: 5114923Abstract: The cDNA sequence encoding porcine brain natriuretic peptide and related genes encoding canine and human peptides with natriuretic activity are disclosed. The gene is shown to make accessible the DNAs encoding analogous natriuretic peptides in other vertebrate species. The genes encoding these NPs can be used to effect modifications of the sequence to produce alternate forms of the NPs and to provide practical amounts of these proteins. The NPs of the invention can also be synthesized chemically. The invention peptides have the formula: ##STR1## wherein R.sup.1 is selected from the group consisting of: ##STR2## or a 10- to 109-amino acid sequence shown as the native upstream sequence for porcine, canine or human NP in FIG. 6, or a composite thereof;R.sup.2 is (OH), NH.sub.2, or NR'R" wherein R' and R" are independently lower alkyl (1-4C) or is ##STR3## or the amides (NH.sub.2 or NR'R") thereof, with the proviso that if formula (1) isR.sup.Type: GrantFiled: February 2, 1990Date of Patent: May 19, 1992Assignee: California Biotechnology Inc.Inventors: Jeffrey J. Seilhamer, John A. Lewicki, Robert M. Scarborough, J. Gordon Porter
-
Patent number: 4907980Abstract: A connector for use in deep ocean environments has a housing defining an interior chamber filled with non-electrically conducting fluid wherein the cable termination is interconnected to a male or female contact apparatus. A pressure equalizing apparatus according to the invention includes a pair of mating sleeves positioned in the interior chamber, in spaced apart relationships, each having a cylindrical mating surface which sealingly mates against the interior surface of the chamber and a projecting sleeve receiving cylindrical surface. The sleeve receiving surfaces are juxtaposed opposite one another. An elastomeric boot is positioned over the sleeve receiving surfaces of each mating sleeve to thereby extend between the pair of sleeves and divide the interior chamber into an interior non-electrically conducting fluid retaining region and an exterior region.Type: GrantFiled: July 14, 1989Date of Patent: March 13, 1990Assignee: Kintec, Inc.Inventors: James P. Wagaman, Gordon A. Porter