Abstract: Embodiments relate to hexagonal fragmentation of terrain. A hive manifest specifying one or more conditions and rules for game level generation using hexagonal terrain tiles is received at a computing device. A set of hexagonal terrain tiles satisfying the one or more conditions and rules specified by the hive manifest are identified. Hexagonal terrain tile definition data corresponding to the identified set of hexagonal terrain tiles is retrieved. A game level using the retrieved hexagonal terrain tile definition data is generated by instantiating a subset of hexagonal terrain tiles of the set of hexagonal terrain tiles as a sub-level of the game level.

Abstract: Embodiments relate to hexagonal fragmentation of terrain. A hive manifest specifying one or more conditions and rules for game level generation using hexagonal terrain tiles is received at a computing device. A set of hexagonal terrain tiles satisfying the one or more conditions and rules specified by the hive manifest are identified. Hexagonal terrain tile definition data corresponding to the identified set of hexagonal terrain tiles is retrieved. A game level using the retrieved hexagonal terrain tile definition data is generated by instantiating a subset of hexagonal terrain tiles of the set of hexagonal terrain tiles as a sub-level of the game level.

Abstract: A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.

Abstract: A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.

Abstract: A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionoperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.

Abstract: The invention relates to the systemic insecticide fipronil in conjunction with a rodenticide used for manufacture of a bait composition to provide a lethal effect on fleas and/or ticks and a host rodent, following ingestion of the bait composition by the host rodent. Preferred rodenticides are brodifacoum, difethialone, flocoumafen, bromadiolone and mixtures thereof. The invention also relates to rodenticidal bait compositions and to a method of killing ticks and a host rodent by providing for ingestion to the rodent, a bait composition comprising an effective amount of a rodenticide and an acaricidally effective amount of fipronil.

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an ophthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.

Abstract: This invention provides methods for selectively antagonizing the ?4?1 integrin heterodimer in a subject in need thereof, and preferably in a human subject. The methods of the invention utilize conjugates comprising two or more ?4?1 small molecule antagonists covalently attached to a biocompatible polymer. These methods of selectively inhibiting ?4?1 may be used modulate both normal and pathological biological processes mediated at least in part through ?4?1 activity.

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.

Abstract: The sign support (300) has a sign holder (2), of any suitable cross-section, accommodating a sign stand (501). A plurality, three being shown, of leg holders (3) are provided about the sign holder (2) each pivotally accommodating a respective leg (4). The legs (4) may be splayed outwardly to provide a support for the sign (500) and may also move vertically, indicated by arrows (A), in the leg holders (3) to accommodate an uneven ground surface. The legs (4) are able to nest together when in their collapsed position so as to minimise the height above ground of the sign support (300) in the event that the sign (500) is blown or knocked over.

Abstract: A method of preparing intraocular lenses in situ is disclosed. The method involves the injection of an unsaturated macromonomer of Formula I: The macromonomer is then polymerized to give a polymer suitable for use in an intraocular lens.

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Abstract: An improved biostable polyurethane-urea elastomeric composition derived from a silicon-containing diamine of formula (I).

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.

Abstract: A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.

Abstract: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

Abstract: The invention relates to the systemic insecticide fipronil in conjunction with a rodenticide used for manufacture of a bait composition to provide a lethal effect on fleas and/or ticks and a host rodent, following ingestion of the bait composition by the host rodent. Preferred rodenticides are brodifacoum, difethialone, flocoumafen, bromadiolone and mixtures thereof. The invention also relates to rodenticidal bait compositions and to a method of killing ticks and a host rodent by providing for ingestion to the rodent, a bait composition comprising an effective amount of a rodenticide and an acaricidally effective amount of fipronil.

Abstract: A method of preparing intraocular lenses in situ is disclosed. The method involves the injection of an unsaturated macromonomer of the formula The macromonomer is then polymerized to give a polymer having an E modulus in the range 0.5-5 kPa.

Abstract: A continuous centrifuge (10) has a basket (30) with upper and lower basket portions (43, 44) separated by an intermediate slip portion (45). The lower basket portion (43) has an included angle of 40–50°, to separate “green” molasses from the sugar crystals, while the upper basket portion (44) has an included angle of 50–60°, to separate washed molasses from the sugar crystals. The inner faces of the walls of the basket portions (43, 44) have radial drainage grooves (46), closed at their lower ends and opens at their upper ends, to discharge the molasses.