Patents by Inventor Gordon M. Ringold

Gordon M. Ringold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human interferon-.beta. (IFN-.beta.) produced in Chinese hamster ovary (CHO) cells
    Patent number: 5795779
    Abstract: .beta.-interferon is produced in Chinese hamster ovary cells (CHO) in high amounts.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: August 18, 1998
    Assignees: Berlex Laboratories, Inc., Leland Stanford Junior University
    Inventors: Francis P. McCormick, Michael A. Innis, Gordon M. Ringold
  • Expression of interferon genes in Chinese hamster ovary cells
    Patent number: 5376567
    Abstract: DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in Chinese hamster ovary (CHO) cells or progeny thereof. The human recombinant interferon so produced contains glycans which are a subset of the population of glycans which are contained in the native counterpart, and may be used in therapeutic formulations. The CHO cells yield high levels of human interferon with no detectable amounts of host, IFN, either constitutive or inductive.
    Type: Grant
    Filed: January 9, 1992
    Date of Patent: December 27, 1994
    Assignees: Berlex Laboratories, Inc., Board of Trustees of the Leland Stanford, Jr. Univ.
    Inventors: Francis P. McCormick, Michael A. Innis, Gordon M. Ringold
  • Expression of interferon genes in Chinese hamster ovary cells
    Patent number: 4966843
    Abstract: DNA constructs are prepared which operably link human interferon genes, selective, eukaryotic marker genes, and promoter and expression control sequences for the expression of human interferon in Chinese hamster ovary (CHO) cells or progeny thereof. The human recombinant interferon so produced contains glycans which are a subset of the population of glycans which are contained in the native counterpart, and may be used in therapeutic formulations. The CHO cells yield high levels of human interferon with no detectable amounts of host IFN, either constitutive or inductive.
    Type: Grant
    Filed: July 31, 1985
    Date of Patent: October 30, 1990
    Assignee: Cetus Corporation
    Inventors: Francis P. McCormick, Michael A. Innis, Gordon M. Ringold
  • Use of tumor necrosis factor as a weight regulator
    Patent number: 4684623
    Abstract: A method for controlling weight by suppressing the normal metabolism of adipose tissue is disclosed. Administration of tumor necrosis factor (TNF) or a pharmaceutical composition containing it results in suppression of anabolism of adipose cells.
    Type: Grant
    Filed: November 26, 1985
    Date of Patent: August 4, 1987
    Assignees: The Board of Trustees of the Cetus Corporation, Leland Stanford Junior University
    Inventors: James W. Larrick, Gordon M. Ringold, David F. Mark, Leo S. Lin, Frank M. Torti
  • Gene amplification in eukaryotic cells
    Patent number: 4656134
    Abstract: Method and compositions are provided for gene amplification. A DNA unit is prepared capable of replication in a eukaryotic host having tandem genes, where the first gene is capable of complementing an auxotrophic host. The auxotrophic host is transformed with the DNA unit under selective conditions requiring enhanced expression of the first gene. Hosts are then selected for amplification of the first and second genes.
    Type: Grant
    Filed: April 12, 1985
    Date of Patent: April 7, 1987
    Assignee: Board of Trustees of Leland Stanford Jr. University
    Inventor: Gordon M. Ringold