Abstract: An optical scanning microscope includes an illumination system (160) and an objective lens (134) operable together to provide the excitation radiation (152, 154) in a focal volume (124) at sufficient intensity to cause emission of emission radiation from a sample in the focal volume. The objective lens (134) is scanned by an objective scanner (130, 132). In this example an x-y transducer (xyXD) (130) is connected to a kinematic flexure mechanism (132) which acts as a scanning lens mount. The kinematic flexure mechanism is operable to scan the objective in two dimensions transverse with respect to the objective's optical axis so as to scan the emitting focal volume in corresponding dimensions. The kinematic flexure mechanism may be a unitary 3D-printed member.

Abstract: Disclosed are methods and systems for diagnosing, staging, stratifying, prognosing, and/or treating bladder cancer. In particular, the invention relates to methods and systems for classifying Stage T1 bladder cancer. The disclosed methods may include generating an mRNA expression profile for a sample of Stage T1 bladder cancer and classifying the sample based on the expression profile.

Abstract: An optical scanning microscope includes an illumination system (160) and an objective lens (134) operable together to provide the excitation radiation (152), (154) in a focal volume (124) at sufficient intensity to cause non-linear emission of emission radiation from a sample in the focal volume. The objective is an aspheric objective configured to focus the excitation radiation without, or with minimal, spherical aberration. The objective lens (134) is scanned by an objective scanner (130), (132). In this example an x-y transducer (xyXD) (130) is connected to a kinematic flexure mechanism (132) which acts as a scanning lens mount. The objective scanner (130), (132) is operable to scan the objective (134) in two dimensions transverse with respect to the objective's optical axis so as to scan the emitting focal volume (124) in corresponding dimensions.

Abstract: An optical scanning microscope includes an illumination system (160) and an objective lens (134) operable together to provide the excitation radiation (152, 154) in a focal volume (124) at sufficient intensity to cause emission of emission radiation from a sample in the focal volume. The objective lens (134) is scanned by an objective scanner (130, 132). In this example an x-y transducer (xyXD) (130) is connected to a kinematic flexure mechanism (132) which acts as a scanning lens mount. The kinematic flexure mechanism is operable to scan the objective in two dimensions transverse with respect to the objective's optical axis so as to scan the emitting focal volume in corresponding dimensions. The kinematic flexure mechanism may be a unitary 3D-printed member.

Abstract: An infrared detection system comprises the following elements. A laser source provides radiation for illuminating a target (5). This radiation is tuned to at least one wavelength in the fingerprint region of the infrared spectrum. A detector (32) detects radiation backscattered from the target (5). An analyser determines from at least the presence or absence of detected signal in said at least one wavelength whether a predetermined volatile compound is present. An associated detection method is also provided. In embodiments, the laser source is tunable over a plurality of wavelengths, and the detector comprises a hyperspectral imaging system. The laser source may be an optical parametric device has a laser gain medium for generating a pump beam in a pump laser cavity, a pump laser source and a nonlinear medium comprising a ZnGeP2 (ZGP) crystal.

Abstract: Described are various embodiments of a computerized method and system for automatically developing a facial remediation protocol for a user based on an input facial image of the user, wherein facial remediation design or plan comprises a combination of one or more of a surgical plan to shift or change the size of various facial anatomical features, a makeup plan to change the apparent size or apparent position of various facial anatomical features and other techniques, such as hair design, to reduce the actual and perceived difference between the subject's face and a standard face, for example.

Abstract: Described are various embodiments of a computerized method and system for automatically developing a facial remediation protocol for a user based on an input facial image of the user, wherein facial remediation design or plan comprises a combination of one or more of a surgical plan to shift or change the size of various facial anatomical features, a makeup plan to change the apparent size or apparent position of various facial anatomical features and other techniques, such as hair design, to reduce the actual and perceived difference between the subject's face and a standard face, for example.

Abstract: An infrared detection system comprises the following elements. A laser source provides radiation for illuminating a target (5). This radiation is tuned to at least one wavelength in the fingerprint region of the infrared spectrum. A detector (32) detects radiation backscattered from the target (5). An analyser determines from at least the presence or absence of detected signal in said at least one wavelength whether a predetermined volatile compound is present. An associated detection method is also provided. In embodiments, the laser source is tunable over a plurality of wavelengths, and the detector comprises a hyperspectral imaging system. The laser source may be an optical parametric device has a laser gain medium for generating a pump beam in a pump laser cavity, a pump laser source and a nonlinear medium comprising a ZnGeP2 (ZGP) crystal.

Abstract: An infrared detection system comprises the following elements. A laser source provides radiation for illuminating a target (5). This radiation is tuned to at least one wavelength in the fingerprint region of the infrared spectrum. A detector (32) detects radiation backscattered from the target (5). An analyzer determines from at least the presence or absence of detected signal in said at least one wavelength whether a predetermined volatile compound is present. An associated detection method is also provided. In embodiments, the laser source is tunable over a plurality of wavelengths, and the detector comprises a hyperspectral imaging system. The laser source may be an optical parametric device has a laser gain medium for generating a pump beam in a pump laser cavity, a pump laser source and a nonlinear medium comprising a ZnGeP2 (ZGP) crystal.

Abstract: According to one aspect, embodiments of the invention provide a method for providing power to a distributed sensor system, the method comprising providing power from at least one port of an interface unit to a first port of a first sensor unit of at least one of a plurality of sensor strings, powering up the first sensor unit, forwarding power from a second port of the first sensor unit to a first port of a second sensor unit of the at least one of the plurality of sensor strings, powering up the second sensor unit, monitoring the plurality of sensor strings for a fault condition, and in response to detecting a fault condition in a first sensor string of the plurality of sensor strings, providing power from a second one of the plurality of sensor strings to the first sensor string.

Abstract: An M2 value beam profiling apparatus and method is described. The M2 value beam profiler comprises an optical axis defined by a focussing lens assembly and a detector, wherein the focussing lens acts to create an artificial waist within an optical field propagating along the optical axis. The beam profiler also comprises a multiple blade assembly having a first set of blades located at an artificial waist position and a second set of blades longitudinally separated along the optical axis from the artificial waist position. The multiple blade assembly therefore provides a means for selectively passing the blades through the location of the optical axis. Employing these measured widths allows for the M2 value of the optical field to be determined.

Abstract: An M2 value beam profiling apparatus and method is described. The M2 value beam profiler comprises an optical axis defined by a focussing lens assembly and a detector, wherein the focussing lens acts to create an artificial waist within an optical field propagating along the optical axis. The beam profiler also comprises a multiple blade assembly having a first set of blades located at an artificial waist position and a second set of blades longitudinally separated along the optical axis from the artificial waist position. The multiple blade assembly therefore provides a means for selectively passing the blades through the location of the optical axis. Employing these measured widths allows for the M2 value of the optical field to be determined.

Abstract: The invention provides an apparatus and a method that reduces fluid loss from a cask during a maturation process by sealably enclosing the cask in a vessel that provides an expansion volume to receive fluid vapor from the cask, a monitoring system and a method that monitors fluid loss from a cask during a maturation process using a light source and a detector to determine the presence of fluid vapor in the vicinity of the cask, a corresponding system for controlling a maturation process in which environmental conditions are controlled, and a cask leak testing system and method making use of the above.

Abstract: According to one aspect, embodiments of the invention provide a method for providing power to a distributed sensor system, the method comprising providing power from at least one port of an interface unit to a first port of a first sensor unit of at least one of a plurality of sensor strings, powering up the first sensor unit, forwarding power from a second port of the first sensor unit to a first port of a second sensor unit of the at least one of the plurality of sensor strings, powering up the second sensor unit, monitoring the plurality of sensor strings for a fault condition, and in response to detecting a fault condition in a first sensor string of the plurality of sensor strings, providing power from a second one of the plurality of sensor strings to the first sensor string.

Abstract: An infrared detection system comprises the following elements. A laser source provides radiation for illuminating a target (5). This radiation is tuned to at least one wavelength in the fingerprint region of the infrared spectrum. A detector (32) detects radiation backscattered from the target (5). An analyser determines from at least the presence or absence of detected signal in said at least one wavelength whether a predetermined volatile compound is present. An associated detection method is also provided. In embodiments, the laser source is tunable over a plurality of wavelengths, and the detector comprises a hyperspectral imaging system. The laser source may be an optical parametric device has a laser gain medium for generating a pump beam in a pump laser cavity, a pump laser source and a nonlinear medium comprising a ZnGeP2 (ZGP) crystal.

Abstract: The present invention is a system, data access management utility and a method of generating links between local merchants and a marketing system. The present invention may be operable to register members, merchants, community programs, intermediaries and other entities with the marketing system. Embodiments of the present invention may be operable to quickly and efficiently register multiple members and/or multiple merchant store types virtually simultaneously to the marketing system. An automated registration and/or boarding process may be operated by the present invention to undertake such registration and/or boarding of members, merchants, community programs, intermediaries and other entities with the marketing system, including automated boarding of merchants.

Abstract: According to one aspect, embodiments of the invention provide a distributed sensor network comprising an interface unit and a plurality of sensor strings, each sensor string comprising a plurality of sensor units coupled in series to a port of the interface unit, wherein each one of the plurality of sensor units is configured to be provided both power and network connectivity via a first cable from one of the interface unit and another sensor unit within the sensor string and also to provide both power and network connectivity via a second cable to another sensor unit within the sensor string, and wherein a first string of the plurality of sensor strings is configured to be coupled to a second string of the plurality of sensor strings and wherein at least one sensor unit within the first string is configured to provide power to a sensor unit within the second string.

Abstract: The invention provides an apparatus and a method that reduces fluid loss from a cask during a maturation process by sealably enclosing the cask in a vessel that provides an expansion volume to receive fluid vapour from the cask, a monitoring system and a method that monitors fluid loss from a cask during a maturation process using a light source and a detector to determine the presence of fluid vapour in the vicinity of the cask, a corresponding system for controlling a maturation process in which environmental conditions are controlled, and a cask leak testing system and method making use of the above.

Abstract: Address, time, and rules obligating donee donations are auto-populated for merchants whose authorization responses for transactions conducted on accounts are used to obtain account holders' travel time to the merchants'. When travel time is proximal to the auto-populated time, the rule and the transaction currency amount are used to calculate the merchant's donee donation, which donation can be messaged for auditing of donations paid and payable. A predetermined time after each such transaction, the merchant is sent a notice as to the difference between obligatory donee donations and the donee donations received. Auto-populated addresses, times, and rules are amendable by the merchant, and the donee amendable by the account holder, whereby the merchant selects the donation, and the account holder selects the donee. Answers to account holder surveys, upon receipt, increments currencies for account holder or donee with greater increment for fast answers.

Abstract: A closure (1) having a shell (10) and a polymer insert (20). The polymer material of the insert (20) is selected to be sufficiently soft to provide an adequate sealing surface (21) and yet sufficiently stiff to define legs (22), which clip behind the internal curl (11) of the closure shell (10).