Patents by Inventor Gottfried Sedelmeier

Gottfried Sedelmeier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes and intermediates for NEP inhibitor synthesis
    Patent number: 10851059
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: December 1, 2020
    Assignee: Novartis AG
    Inventors: Florian Karl Kleinbeck-Riniker, Ives Mafli, Benjamin Martin, Gerhard Penn, Gottfried Sedelmeier, Joerg Sedelmeier, Francesco Venturoni
  • NEW PROCESSES AND INTERMEDIATES FOR NEP INHIBITOR SYNTHESIS
    Publication number: 20190202785
    Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.
    Type: Application
    Filed: August 16, 2017
    Publication date: July 4, 2019
    Inventors: Florian Karl KLEINBECK-RINIKER, Ives MAFLI, Benjamin MARTIN, Gerhard PENN, Gottfried SEDELMEIER, Joerg SEDELMEIER, Francesco VENTURONI
  • N-phenyl-2-pyrimidine-amine derivatives
    Patent number: 9573928
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: February 21, 2017
    Assignee: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • Aminoalkanol derivatives
    Patent number: 9415024
    Abstract: Disclosed are compounds of formula I wherein R1, R2, R5 and R6 are as defined in the claims; such compounds have interesting pharmacological properties.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: August 16, 2016
    Assignee: Novartis AG
    Inventors: Ernst Küsters, Lukas Oberer, Gottfried Sedelmeier
  • Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
    Patent number: 9206116
    Abstract: The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: December 8, 2015
    Assignee: NOVARTIS AG
    Inventors: David Hook, Thomas Ruch, Bernard Riss, Bernhard Wietfeld, Gottfried Sedelmeier, Matthias Napp, Markus Bänziger, Steven Hawker, Lech Ciszewski, Liladhar Murlidhar Waykole
  • Process for the production of 2-amino-2[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diols, and to compounds for use therein
    Patent number: 9133096
    Abstract: The present invention relates to improved processes for the production of 2-amino-2-[2-(4-C2-20alkyl-phenyl)ethyl]propane-1,3-diols, and to compounds for use therein.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: September 15, 2015
    Assignee: Novartis AG
    Inventor: Gottfried Sedelmeier
  • Process for Preparing 5-biphenyl-4-amino-2-methyl Pentanoic Acid
    Publication number: 20150166468
    Abstract: The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
    Type: Application
    Filed: February 20, 2015
    Publication date: June 18, 2015
    Inventors: David Hook, Thomas Ruch, Bernard Riss, Bernhard Wietfeld, Gottfried Sedelmeier, Matthias Napp, Markus Bänziger, Steven Hawker, Lech Ciszewski, Liladhar Murlidhar Waykole
  • Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
    Patent number: 8993785
    Abstract: The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
    Type: Grant
    Filed: March 25, 2014
    Date of Patent: March 31, 2015
    Assignee: Novartis AG
    Inventors: David Hook, Thomas Ruch, Bernard Riss, Bernhard Wietfeld, Gottfried Sedelmeier, Matthias Napp, Markus Bänziger, Steven Hawker, Lech Ciszewski, Liladhar Murlidhar Waykole
  • N-Phenyl-2-pyrimidine-amine Derivatives
    Publication number: 20150018552
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Application
    Filed: September 30, 2014
    Publication date: January 15, 2015
    Applicant: Novartis AG
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • Process for Preparing 5-biphenyl-4-amino-2-methyl Pentanoic Acid
    Publication number: 20140249320
    Abstract: The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
    Type: Application
    Filed: March 25, 2014
    Publication date: September 4, 2014
    Inventors: David Hook, Thomas Ruch, Bernard Riss, Bernhard Wietfeld, Gottfried Sedelmeier, Matthias Napp, Markus Bänziger, Steven Hawker, Lech Ciszewski, Liladhar Murlidhar Waykole
  • Process for the production of 2-amino-2-[2-(4-C-alkyl-phenyl)ethyl]propane-1,3-diols, and to compounds for use therein
    Patent number: 8809571
    Abstract: The present invention relates to improved processes for the production of 2-amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diols, and to compounds for use therein.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: August 19, 2014
    Assignee: Novartis AG
    Inventor: Gottfried Sedelmeier
  • Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
    Patent number: 8716495
    Abstract: The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: May 6, 2014
    Assignee: Novartis AG
    Inventors: David Hook, Thomas Ruch, Bernhard Riss, Bernhard Wietfeld, Gottfried Sedelmeier, Matthias Napp, Markus Bänziger, Steven Hawker, Lech Ciszewski, Liladhar M Waykole
  • Process
    Publication number: 20140094625
    Abstract: The present invention relates to improved processes for the production of 2-amino-2-[2-(4-C2-20 alkyl-phenyl)ethyl]propane-1,3-diols, and to compounds for use therein.
    Type: Application
    Filed: November 8, 2013
    Publication date: April 3, 2014
    Applicant: NOVARTIS AG
    Inventor: Gottfried Sedelmeier
  • AMINOALKANOL DERIVATIVES
    Publication number: 20130289127
    Abstract: Disclosed are compounds of formula I wherein R1, R2, R5 and R6 are as defined in the claims; such compounds have interesting pharmacological properties.
    Type: Application
    Filed: June 13, 2013
    Publication date: October 31, 2013
    Inventors: Ernst Küsters, Lukas Oberer, Gottfried Sedelmeier
  • Process for the preparation of tetrazole derivatives from organo boron and organo aluminium azides
    Patent number: 8569528
    Abstract: The present invention relates to a method for preparing substituted tetrazoles, compounds obtained according to this method, new reactants and new tetrazole derivatives.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: October 29, 2013
    Assignee: Novartis AG
    Inventor: Gottfried Sedelmeier
  • PROCESS FOR THE PREPARATION OF TETRAZOLE DERIVATIVES FROM ORGANO BORON AND ORGANO ALUMINIUM AZIDES
    Publication number: 20120330026
    Abstract: The present invention relates to a method for preparing substituted tetrazoles, compounds obtained according to this method, new reactants and new tetrazole derivatives.
    Type: Application
    Filed: September 5, 2012
    Publication date: December 27, 2012
    Inventor: Gottfried Sedelmeier
  • Methods for the production of C-8 lactam lactone compounds
    Patent number: 8338620
    Abstract: The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren, the invention relates to a process for the manufacture of a compound of the formula I, or a salt thereof, wherein R1 as well as Act are as defined in the specification, and processes of manufacturing this compound as well as intermediates in this process.
    Type: Grant
    Filed: April 1, 2008
    Date of Patent: December 25, 2012
    Assignee: Novartis AG
    Inventor: Gottfried Sedelmeier
  • PROCESS FOR THE MANUFACTURE OF ORGANIC COMPOUNDS
    Publication number: 20120238761
    Abstract: The present invention relates to processes for the manufacture of an angiotensin receptor blocker (ARB; also called angiotension II receptor antagonist or AT1 receptor antagonist) and salts thereof, to novel intermediates and process steps.
    Type: Application
    Filed: October 25, 2010
    Publication date: September 20, 2012
    Inventors: Gottfried Sedelmeier, Florian Andreas Rampf, Dominique Grimler
  • N-Phenyl-2-pyrimidine-amine Derivatives
    Publication number: 20120226039
    Abstract: The present invention relates to novel amides and a process for preparing these amides.
    Type: Application
    Filed: May 17, 2012
    Publication date: September 6, 2012
    Inventors: Olivier Loiseleur, Daniel Kaufmann, Stephan Abel, Hans Michael Bürger, Mark Meisenbach, Beat Schmitz, Gottfried Sedelmeier
  • 3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors
    Patent number: 8198465
    Abstract: The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula II, or a salt thereof, and a compound of formula VI or a salt thereof, wherein R3 and R4 as well as Act are as defined in the specification, and processes of manufacturing these. Additionally transformation of compounds (VI) with metallo organic compounds (VII) give rise to the new compounds (VIII) which are direct precursors for the preparation of Aliskiren.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: June 12, 2012
    Assignee: Novartis AG
    Inventors: Gottfried Sedelmeier, Dominique Grimler, Murat Acemoglu