Patents by Inventor Grace Chan
Grace Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220017609Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.Type: ApplicationFiled: March 5, 2021Publication date: January 20, 2022Inventors: James E. Hansen, Peter M. Glazer, Richard H. Weisbart, Robert N. Nishimura, Grace Chan
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Patent number: 10961301Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.Type: GrantFiled: June 6, 2017Date of Patent: March 30, 2021Assignees: Yale University, The Regents of the University of California, The United States Government Represented by the Department of Veterans AffairsInventors: James E. Hansen, Peter M. Glazer, Richard H. Weisbart, Robert N. Nishimura, Grace Chan
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Publication number: 20170334981Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.Type: ApplicationFiled: June 6, 2017Publication date: November 23, 2017Inventors: James E. Hansen, Peter M. Glazer, Richard H. Weisbart, Robert N. Nishimura, Grace Chan
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Patent number: 9701740Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.Type: GrantFiled: April 2, 2012Date of Patent: July 11, 2017Assignees: YALE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, The United States of America represented by the Department of Veterans AffairsInventors: James E. Hansen, Peter M. Glazer, Richard H. Weisbart, Robert N. Nishimura, Grace Chan
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Publication number: 20140050723Abstract: Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.Type: ApplicationFiled: April 2, 2012Publication date: February 20, 2014Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, YALE UNIVERSITYInventors: James E. Hansen, Peter M. Glazer, Richard H. Weisbart, Robert N. Nishimura, Grace Chan
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Patent number: 7060172Abstract: The apparatus includes a container (20) having a base (22) and sides (32) adapted to receive a plurality of plastic gel cassettes. An inlet port (12) is positioned in the base of the container and in fluid communication with the chamber and a baffle (11) is positioned over the inlet port, such that, in use, when gel forming fluid passes through the inlet port into the chamber, the baffle substantially reduces fluid turbulence and vertical fluid movement in the vicinity of the inlet port during flow of the fluid into the chamber. Pretreatment of the plastic cassette to remove polymerisation inhibitors prior to filling the same with fluid is by exhaustive vacuum treatment, optionally with nitrogen gas purging. This can be achieved conveniently using a vacuum chamber in which one or more plastic cassettes are placed. Optionally the vacuum chamber may be the container in which the cassettes are filled with fluid. No barrier films or chemical scavengers are required.Type: GrantFiled: April 9, 1999Date of Patent: June 13, 2006Assignee: Life Therapeutics LimitedInventors: David Solomon, Grace Chan
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Publication number: 20050228120Abstract: A polymer comprising one or more macromonomer units selected from the group consisting of polysiloxane, perfluoroalkylpolyether (PFPE), fluorinated poly(meth)acrylate, polyalkyl (meth)acrylate, polyolefin and fluorinated polyolefin, and one or more charged units (such as an anionic, cationic or zwitter-ionic monomer), formed from a polymerization medium containing an aqueous solution of charged units and use of this polymer as an intraocular lens for the implantation into or onto the cornea. Another aspects relates to a process for coating the above polymer with an adhesive comprising covalently coupling co-reactive surface functional groups of a natural or synthetic polymer with functional groups present (or introduced) on the surface of the macromonomer containing polymer, followed by covalently coupling a multifunctionally activated compound having at least one functional group that is co-reactive to the reactive groups of the natural or synthetic polymer.Type: ApplicationFiled: May 21, 2003Publication date: October 13, 2005Inventors: Timothy Hughes, Grace Chan
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Patent number: 6818718Abstract: Method of separating molecules by providing a cross-linked polymer gel having a cross-linking moiety of the formula wherein X, X′, Y, Z and R2 are as defined in the specification. A sample containing the molecules to be separated is placed on the gel, and the gel is subjected to a separation technique.Type: GrantFiled: December 21, 2000Date of Patent: November 16, 2004Assignee: The University of MelbourneInventors: David Henry Solomon, Grace Chan, Peter Agapitus Kambouris, Mark Graham Looney
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Publication number: 20010020079Abstract: Method of separating molecules by providing a cross-linked polymer gel having a cross-linking moiety of the formula 1Type: ApplicationFiled: December 21, 2000Publication date: September 6, 2001Applicant: The University of MelbourneInventors: David Henry Solomon, Grace Chan, Peter Agapitos Kambouris, Mark Graham Looney
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Patent number: 6197906Abstract: This invention relates to the separation of molecules on polymer gels, in particular to novel cross-linked polymer gels comprising the cross-linking moiety of for formula (1) and their preparation, the separation of molecules by techniques such as electrophoresis using these gels, novel cross-linking agents useful in the preparation of the gels, and novel intermediates useful in the synthesis of the cross-linking agents. The invention is especially suitable for electrophoretic applications.Type: GrantFiled: February 18, 1999Date of Patent: March 6, 2001Assignee: The University of MelbourneInventors: David Henry Solomon, Grace Chan, Peter Agapitos Kambouris, Mark Graham Looney
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Patent number: D417445Type: GrantFiled: July 31, 1998Date of Patent: December 7, 1999Assignee: Intermec IP Corp.Inventors: Debbie A. Chacon, Grace Chan