Patents by Inventor Grace DeSantis

Grace DeSantis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Preparing Directional Tagmentation Sequencing Libraries Using Transposon-Based Technology with Unique Molecular Identifiers for Error Correction
    Publication number: 20240026348
    Abstract: Materials and methods for preparing nucleic acid libraries for next-generation sequencing are described herein. A variety of approaches are described relating to the use of unique molecular identifiers with transposon-based technology in the preparation of sequencing libraries. Also described herein are sequencing materials and methods for identifying and correcting amplification and sequencing errors.
    Type: Application
    Filed: September 28, 2023
    Publication date: January 25, 2024
    Applicants: Illumina, Inc., Illumina Cambridge Limited
    Inventors: Susan C. Verity, Robert Scott Kuersten, Niall Anthony Gormley, Andrew B. Kennedy, Sarah E. Shultzaberger, Andrew Slatter, Emma Bell, Sebastien Georg Gabriel Ricoult, Grace DeSantis, Fiona Kaper, Han-Yu Chuang, Oliver Jon Miller, Jason Richard Betley, Stephen M. Gross, Mats Ekstrand
  • Tagmentation Using Immobilized Transposomes With Linkers
    Publication number: 20230392142
    Abstract: The present disclosure relates to methods, compositions, and kits for treating target nucleic acids, including methods and compositions for fragmenting and tagging nucleic acid (e.g., DNA) using transposome complexes bound to a solid support.
    Type: Application
    Filed: June 1, 2023
    Publication date: December 7, 2023
    Applicants: Illumina, Inc., Illumina Cambridge Limited
    Inventors: Grace Desantis, Stephen M. Gross, Jian-Sen Li, Natalie Morrell, Andrew Slatter, Kevin Shen, Samantha Snow
  • Tagmentation using immobilized transposomes with linkers
    Patent number: 11708573
    Abstract: The present disclosure relates to methods, compositions, and kits for treating target nucleic acids, including methods and compositions for fragmenting and tagging nucleic acid (e.g., DNA) using transposome complexes bound to a solid support.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: July 25, 2023
    Assignees: Illumina, Inc.
    Inventors: Grace DeSantis, Stephen M. Gross, Jian-Sen Li, Natalie Morrell, Andrew Slatter, Kevin Shen, Samantha Snow
  • Methods and Processes for Non-Invasive Assessment of Genetic Variations
    Publication number: 20220356523
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: March 25, 2022
    Publication date: November 10, 2022
    Applicant: Sequenom, Inc.
    Inventors: Charles R. Cantor, Grace DeSantis, Reinhold Mueller, Mathias Ehrich
  • Methods and processes for non-invasive assessment of genetic variations
    Patent number: 11312997
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: April 26, 2022
    Assignee: Sequenom, Inc.
    Inventors: Charles R. Cantor, Grace DeSantis, Reinhold Mueller, Mathias Ehrich
  • Compositions and Methods for Improving Library Enrichment
    Publication number: 20210164027
    Abstract: This disclosure describes a hybridization buffer including a crowding agent, a method that includes using the hybridization buffer, and a kit including the hybridization buffer. This disclosure also describes blockers for use in hybrid capture methods, methods of using those blockers, and a kit including those blockers. Additionally, this disclosure describes a method of hybrid capture that does not include amplifying the library members using PCR prior to sequencing the library members.
    Type: Application
    Filed: August 13, 2019
    Publication date: June 3, 2021
    Applicants: Illumina, Inc., Illumina Cambridge Limited
    Inventors: Andrew F. Slatter, Junhua Zhao, Grace DeSantis, Stephen M. Gross, Hayley Marianne Hogan, Jian-Sen Li, Oliver Jon Miller
  • Tagmentation Using Immobilized Transposomes With Linkers
    Publication number: 20210139887
    Abstract: The present disclosure relates to methods, compositions, and kits for treating target nucleic acids, including methods and compositions for fragmenting and tagging nucleic acid (e.g., DNA) using transposome complexes bound to a solid support.
    Type: Application
    Filed: January 4, 2021
    Publication date: May 13, 2021
    Applicants: Illumina, Inc., Illumina Cambridge Limited
    Inventors: Grace DeSantis, Stephen M. Gross, Jian-Sen Li, Natalie Morrell, Andrew Slatter, Kevin Shen, Samantha Snow
  • Tagmentation using immobilized transposomes with linkers
    Patent number: 10920219
    Abstract: The present disclosure relates to methods, compositions, and kits for treating target nucleic acids, including methods and compositions for fragmenting and tagging nucleic acid (e.g., DNA) using transposome complexes bound to a solid support.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: February 16, 2021
    Assignees: ILLUMINA, INC.
    Inventors: Grace DeSantis, Stephen M. Gross, Jian-Sen Li, Natalie Morrell, Andrew Slatter, Kevin Shen, Samantha Snow
  • Methods and Processes for Non-Invasive Assessment of Genetic Variations
    Publication number: 20200362412
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: May 27, 2020
    Publication date: November 19, 2020
    Applicant: Sequenom, Inc.
    Inventors: Charles R. Cantor, Grace DeSantis, Reinhold Mueller, Mathias Ehrich
  • Methods and processes for non-invasive assessment of genetic variations
    Patent number: 10738359
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: August 11, 2020
    Assignee: Sequenom, Inc.
    Inventors: Charles R. Cantor, Grace DeSantis, Reinhold Mueller, Mathias Ehrich
  • TAGMENTATION USING IMMOBILIZED TRANSPOSOMES WITH LINKERS
    Publication number: 20180245069
    Abstract: The present disclosure relates to methods, compositions, and kits for treating target nucleic acids, including methods and compositions for fragmenting and tagging nucleic acid (e.g., DNA) using transposome complexes bound to a solid support.
    Type: Application
    Filed: February 20, 2018
    Publication date: August 30, 2018
    Inventors: Grace DeSantis, Stephen M. Gross, Jian-Sen Li, Natalie Morrell, Andrew Slatter, Kevin Shen, Samantha Snow
  • Nitrilases, nucleic acids encoding them and methods for making and using them
    Patent number: 9828594
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: November 28, 2017
    Assignee: BASF Enzymes LLC
    Inventors: Kelvin Wong, Jay M. Short, Mark J. Burk, Grace Desantis, Robert Farwell, Kelly Chatman
  • METHODS AND PROCESSES FOR NON-INVASIVE ASSESSMENT OF GENETIC VARIATIONS
    Publication number: 20170321276
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Application
    Filed: February 27, 2017
    Publication date: November 9, 2017
    Inventors: Charles R. CANTOR, Grace DeSANTIS, Reinhold MUELLER, Mathias EHRICH
  • Laccases for bio-bleaching
    Patent number: 9677053
    Abstract: Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins, other phenolic, and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: June 13, 2017
    Assignees: BASF Enzymes LLC, BASF SE
    Inventors: Janne Samuli Kerovuo, Sylke Haremza, Oliver Koch, Tilo Habicher, Dan E. Robertson, Grace Desantis, Ryan McCann, Peter Luginbuhl
  • Methods and processes for non-invasive assessment of genetic variations
    Patent number: 9605313
    Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: March 28, 2017
    Assignee: SEQUENOM, INC.
    Inventors: Charles R. Cantor, Grace DeSantis, Reinhold Mueller, Mathias Ehrich
  • NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM
    Publication number: 20160355801
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Application
    Filed: March 8, 2016
    Publication date: December 8, 2016
    Inventors: KELVIN WONG, JAY M. SHORT, MARK J. BURK, GRACE DESANTIS, ROBERT FARWELL, KELLY CHATMAN
  • LACCASES FOR BIO-BLEACHING
    Publication number: 20160237411
    Abstract: Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins, other phenolic, and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers.
    Type: Application
    Filed: April 28, 2016
    Publication date: August 18, 2016
    Inventors: JANNE SAMULI KEROVUO, SYLKE HAREMZA, OLIVER KOCH, TILO HABICHER, DAN E. ROBERTSON, GRACE DESANTIS, RYAN MCCANN, PETER LUGINBUHL
  • Laccases for bio-bleaching
    Patent number: 9353477
    Abstract: Provided herein are isolated laccase enzymes and nucleic acids encoding them. Also provided are mediators for laccase reactions. Also provided herein are methods for using laccases to oxidize lignins and other phenolic and aromatic compounds, such as for bio-bleaching and decolorization of wood pulp under high temperature and pH conditions to facilitate a substantial reduction in use of bleaching chemicals, as well as for treatment of fibers.
    Type: Grant
    Filed: January 7, 2015
    Date of Patent: May 31, 2016
    Assignee: BASF Enzymes LLC
    Inventors: Janne Samuli Kerovuo, Sylke Haremza, Oliver Koch, Tilo Habicher, Dan E. Robertson, Grace Desantis, Ryan McCann, Peter Luginbuhl
  • Nitrilases, nucleic acids encoding them and methods for making and using them
    Patent number: 9315792
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: April 19, 2016
    Assignee: BASF Enzymes LLC
    Inventors: Kelvin Wong, Jay M. Short, Mark J. Burk, Grace DeSantis, Robert Farwell, Kelly Chatman
  • Nitrilases, nucleic acids encoding them and methods for making and using them
    Patent number: 9217164
    Abstract: The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: December 22, 2015
    Assignee: BASF Enzymes LLC
    Inventors: Jennifer A. Chaplin, Ellen Chi, Grace DeSantis, Mark Madden, Darcy Madden, Aileen Milan, Dan E. Robertson, Jay M. Short, David P. Weiner