Patents by Inventor Grace M. Credo
Grace M. Credo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10203297Abstract: Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.Type: GrantFiled: October 9, 2015Date of Patent: February 12, 2019Assignee: Intel CorporationInventors: Jonathan S. Daniels, Oguz H. Elibol, Grace M. Credo, Xing Su
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Publication number: 20180322590Abstract: Apparatuses, methods and storage media associated with agricultural testing and optimization are disclosed herein. In embodiments, an apparatus for performing agricultural testing and optimization may comprise a cavity to receive a container of soil nutrient solution sample of a location in an agricultural region; one or more sensors to collect sensor data from the soil nutrient solution sample; and one or more agricultural testing and optimization applications to perform agricultural testing and optimization for the location, based at least in part on the sensor data collected from the soil nutrient solution sample. Other embodiments may be disclosed or claimed.Type: ApplicationFiled: January 4, 2018Publication date: November 8, 2018Inventors: NARAYAN SUNDARARAJAN, GRACE M. CREDO, TARA K. THIMMANAIK, KAZI I. HUQUE, SRINIVAS B. GARUDACHAR, KATALIN K. BARTFAI-WALCOTT, KHURSHADUZZAMAN RAZIB, FAHIM HASNAEEN, NUZHAT BINTE ARIF
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Publication number: 20170234825Abstract: Various embodiments provide devices, methods, and systems for high throughput biomolecule detections using transducer arrays. In one embodiment, a transducer array made up of a plurality of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can have a single molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap suitable for conducting redox cycling reactions. In embodiments, by flowing chamber contents, from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule, in the reaction chamber of the at least one transducer element through the fingerprinting region, the redox cycling reactions can be detected to identify the redox-tagged biomolecules.Type: ApplicationFiled: December 13, 2016Publication date: August 17, 2017Inventors: Oguz H. ELIBOL, Grace M. CREDO, Xing SU, Madoo VARMA, Jonathan S. DANIELS, Drew HALL, Handong LI, Noureddine TAYEBI, Kai WU
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Patent number: 9551682Abstract: Various embodiments provide devices, methods, and systems for high throughput biomolecule detection using transducer arrays. In one embodiment, a transducer array made up of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region, configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can include a molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap for conducting redox cycling reactions. In embodiments, by flowing the chamber content obtained from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule in the reaction chamber through the fingerprinting region, the redox cycling reactions can be detected to identify redox-tagged biomolecules.Type: GrantFiled: June 29, 2012Date of Patent: January 24, 2017Assignee: INTEL CORPORATIONInventors: Oguz H. Elibol, Grace M. Credo, Xing Su, Madoo Varma, Jonathan S. Daniels, Drew Hall, Handong Li, Noureddine Tayebi, Kai Wu
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Patent number: 9500617Abstract: Embodiments of the invention provide transducers capable of functioning as electronic sensors and redox cycling sensors. Transducers comprise two electrodes separated by a nanogap. Molecular binding regions proximate to and within the nanogap are provided. Methods of fabricating nanogap transducers and arrays of nanogap transducers are also provided. Arrays of individually addressable nanogap transducers can be disposed on integrated circuit chips and operably coupled to the integrated circuit chip.Type: GrantFiled: December 28, 2011Date of Patent: November 22, 2016Assignee: Intel CorporationInventors: Grace M. Credo, Oguz H. Elibol
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Publication number: 20160282265Abstract: An embodiment includes a sensor comprising a substrate die; a photonic ring resonator (RR) on the substrate die; a polymer, on the RR, having an affinity to a chemical analyte; a photonic waveguide on the substrate die and coupled to the RR; a laser, on the substrate die and coupled to the waveguide, to emit optical energy that operates with the RR at a resonance wavelength; and a photodetector, on the substrate die and coupled to the waveguide, to detect a change in refractive index (RI) of the RR operating with the optical energy in response to the polymer coupling to the analyte. Other embodiments are described herein.Type: ApplicationFiled: March 26, 2015Publication date: September 29, 2016Inventors: Xing Su, Kadhair Al-Hemyari, Kai Wu, Grace M. Credo, Haisheng Rong, Jacob Sendowski
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Patent number: 9322798Abstract: Embodiments of the invention provide transducers capable of transducing redox active chemical signals into electrical signals. Transducers comprise two electrodes separated by a nanogap. At least one electrode is comprised of conducting diamond. Methods of fabricating nanogap transducers and arrays of nanogap transducers are provided. Arrays of individually addressable nanogap transducers can be disposed on integrated circuit chips and operably coupled to the integrated circuit chip.Type: GrantFiled: December 15, 2011Date of Patent: April 26, 2016Assignee: INTEL CORPORATIONInventors: Oguz H. Elibol, Onur C. Akkaya, Grace M. Credo, Jonathan S. Daniels, Noureddine Tayebi
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Publication number: 20160033444Abstract: Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.Type: ApplicationFiled: October 9, 2015Publication date: February 4, 2016Inventors: Jonathan S. DANIELS, Oguz H. ELIBOL, Grace M. CREDO, Xing SU
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Patent number: 9222908Abstract: Described herein is a device comprising: a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a fluid and having a capacitance; first circuitry configured to controllably set the plurality of first reaction electrode to a predetermined voltage and allow the capacitance of the plurality of first reaction electrode to charge or discharge through the fluid; and second circuitry configured to measure a rate of charging or discharging of the capacitance of the plurality of first reaction electrodes. Also described herein is a method of using this device to sequence DNA.Type: GrantFiled: March 15, 2013Date of Patent: December 29, 2015Assignee: INTEL CORPORATIONInventors: Jonathan S. Daniels, Oguz H. Elibol, Grace M. Credo, Xing Su
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Patent number: 9176087Abstract: Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.Type: GrantFiled: May 1, 2014Date of Patent: November 3, 2015Assignee: INTEL CORPORATIONInventors: Jonathan S. Daniels, Oguz H. Elibol, Grace M. Credo, Xing Su
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Publication number: 20140299485Abstract: Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.Type: ApplicationFiled: May 1, 2014Publication date: October 9, 2014Inventors: Jonathan S. Daniels, Oguz H. Elibol, Grace M. Credo, Xing Su
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Publication number: 20140190824Abstract: Embodiments of the invention provide transducers capable of functioning as electronic sensors and redox cycling sensors. Transducers comprise two electrodes separated by a nanogap. Molecular binding regions proximate to and within the nanogap are provided. Methods of fabricating nanogap transducers and arrays of nanogap transducers are also provided. Arrays of individually addressable nanogap transducers can be disposed on integrated circuit chips and operably coupled to the integrated circuit chip.Type: ApplicationFiled: December 28, 2011Publication date: July 10, 2014Inventors: Grace M. Credo, Oguz H. Elibol
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Patent number: 8741117Abstract: Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.Type: GrantFiled: September 27, 2012Date of Patent: June 3, 2014Assignee: Intel CorporationInventors: Jonathan S. Daniels, Oguz H. Elibol, Grace M. Credo, Xing Su
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Patent number: 8715932Abstract: Nucleic acid sequencing using concatemers of DNA is provided. Optionally, amplified reaction products from the repeated incorporation and excision of a nucleoside complementary to a nucleoside of the DNA to be sequenced onto primer molecules hybridized to the concatemers of DNA are detected. Nucleic acid sequencing using concatemers of DNA and non-natural oligonucleotides is also provided. Nucleic acid sequencing reactions are detected electronically and or optically using arrays of detectors.Type: GrantFiled: August 20, 2010Date of Patent: May 6, 2014Assignee: Intel CorporationInventors: Xing Su, Kai Wu, Liming Wang, Jianquan Liu, Grace M. Credo
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Publication number: 20140083866Abstract: Described herein is a device comprising: a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a fluid and having a capacitance; first circuitry configured to controllably set the plurality of first reaction electrode to a predetermined voltage and allow the capacitance of the plurality of first reaction electrode to charge or discharge through the fluid; and second circuitry configured to measure a rate of charging or discharging of the capacitance of the plurality of first reaction electrodes. Also described herein is a method of using this device to sequence DNA.Type: ApplicationFiled: March 15, 2013Publication date: March 27, 2014Inventors: Jonathan S. DANIELS, Oguz H. ELIBOL, Grace M. CREDO, Xing SU
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Publication number: 20140083871Abstract: Described herein is a device comprising a plurality of first reaction electrodes arranged in an array, the plurality of first reaction electrodes configured to be exposed to a solution and having a capacitance; first circuitry configured to controllably connect the plurality of first reaction electrodes to a bias source and controllably disconnect the plurality of first reaction electrodes from the bias source; and second circuitry configured to measure a rate of charging or discharging of the capacitance. Also described herein is a method of using this device to sequence DNA.Type: ApplicationFiled: September 27, 2012Publication date: March 27, 2014Inventors: Jonathan S. Daniels, Oguz H. Elibol, Grace M. Credo, Xing Su
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Publication number: 20140001055Abstract: Various embodiments provide devices, methods, and systems for high throughput biomolecule detection using transducer arrays. In one embodiment, a transducer array made up of transducer elements may be used to detect byproducts from chemical reactions that involve redox genic tags. Each transducer element may include at least a reaction chamber and a fingerprinting region, configured to flow a fluid from the reaction chamber through the fingerprinting region. The reaction chamber can include a molecule attachment region and the fingerprinting region can include at least one set of electrodes separated by a nanogap for conducting redox cycling reactions. In embodiments, by flowing the chamber content obtained from a reaction of a latent redox tagged probe molecule, a catalyst, and a target molecule in the reaction chamber through the fingerprinting region, the redox cycling reactions can be detected to identify redox-tagged biomolecules.Type: ApplicationFiled: June 29, 2012Publication date: January 2, 2014Inventors: Oguz H. Elibol, Grace M. Credo, Xing Su, Madoo Varma, Jonathan S. Daniels, Drew Hall, Handong Li, Noureddine Tayebi, Kai Wu
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Publication number: 20130281325Abstract: Embodiments of the invention provide transducers capable of transducing redox active chemical signals into electrical signals. Transducers comprise two electrodes separated by a nanogap. At least one electrode is comprised of conducting diamond. Methods of fabricating nanogap transducers and arrays of nanogap transducers are provided. Arrays of individually addressable nanogap transducers can be disposed on integrated circuit chips and operably coupled to the integrated circuit chip.Type: ApplicationFiled: December 15, 2011Publication date: October 24, 2013Inventors: Oguz H. Elibol, Onur C. Akkaya, Grace M. Credo, Jonathan S. Daniels, Noureddine Tayebi
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Patent number: 8500979Abstract: Devices and methods are presented for electronic sensing of chemical and biochemical analytes. An electronic sensor having a at least two electrodes separated by a nanoscale gap wherein the separation between the first electrode and the second electrode forms a cavity capable of containing a fluid wherein two or more posts comprised of an insulating material extend into the cavity from the face of the first electrode to the face of the second electrode. Optionally, the cavity is closed with a bead. Devices according to embodiments of the invention are capable of detecting chemicals and biochemicals through redox cycling events. Additionally, devices and methods according to embodiments of the invention are adapted to identify and sequence nucleic acid molecules.Type: GrantFiled: December 31, 2009Date of Patent: August 6, 2013Assignee: Intel CorporationInventors: Oguz H. Elibol, Jonathan S. Daniels, Grace M. Credo, Xing Su
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Patent number: D839108Type: GrantFiled: May 31, 2017Date of Patent: January 29, 2019Assignee: Intel CorporationInventors: Narayan Sundararajan, Grace M. Credo, Khurshaduzzaman Razib, Nuzhat Binte. Arif, Fahim Al. Hasnaeen, Kazi I. Huque